A5085672511- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Facial Nerve Paralysis Treatment and Research
- Pituitary Gland Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Cerebral Palsy and Movement Disorders
- Parkinson's Disease and Spinal Disorders
- Neuroendocrine Tumor Research Advances
- Advanced Chemical Sensor Technologies
- Trigeminal Neuralgia and Treatments
- Orthopedic Surgery and Rehabilitation
- Muscle activation and electromyography studies
- Shoulder Injury and Treatment
- Balance, Gait, and Falls Prevention
- Myofascial pain diagnosis and treatment
- melanin and skin pigmentation
- Peripheral Nerve Disorders
- Growth Hormone and Insulin-like Growth Factors
- Tendon Structure and Treatment
- Glycogen Storage Diseases and Myoclonus
- Epilepsy research and treatment
- Biochemical Analysis and Sensing Techniques
- RNA regulation and disease
- Acute Ischemic Stroke Management
Western Galilee Hospital
2021-2024
Bar-Ilan University
2021-2024
Technion – Israel Institute of Technology
2005-2018
Carmel Medical Center
2004-2017
Rappaport Family Institute for Research in the Medical Sciences
2016
Tetrabenazine (TBZ) is a catecholamine depletor used for the treatment of variety movement disorders. The purpose this study was to assess efficacy TBZ in retrospective chart review 3 tertiary care disorders centers over long-term treatment. Of 150 patients whom prescribed, 118 were followed up and assessed using Clinical Global Impression Change (CGIC), (−3 +3), composite grade from patient caregiver scale variable periods. had hyperkinetic including dystonia (generalized focal: axial,...
Mutations in the glucocerebrosidase (GBA) gene have been recently identified as contributory to Parkinson disease (PD) Ashkenazi Jews. In present study, clinical characteristics of patients with PD GBA mutations (n = 40) were compared those without any known mutation 108). The overall manifestations and age at onset did not differ mutations.
The tight junction proteins (TJPs) are major determinants of endothelial cells comprising physiological vascular barriers such as the blood-brain barrier, but little is known about their expression and role in immune cells. In this study we assessed TJP human leukocyte subsets, induction by activation modulation associated with autoimmune disease states therapies. A consistent complexes was detected peripheral blood leukocytes (PBLs), predominantly B T lymphocytes monocytes, whereas vitro...
Early diagnosis of Parkinson's disease (PD) is important because it affects the choice therapy and subject to a relatively high degree error. In addition, early detection PD can potentially enable start neuroprotective before extensive loss dopaminergic neurons substantia nigra occurs. However, until now, studies for using volatile biomarkers sampled only treated medicated patients. Therefore, there great need evaluate untreated patients establishing real world screening diagnostic...
Abstract The common belief that primary dystonia is a purely motor disorder has recently been challenged. We examined separately the cognitive profiles of symptomatic (SYM) and nonsymptomatic (N‐SYM) groups carriers DYT1 mutation using comprehensive neuropsychological test battery. Self‐report inventories anxiety, depression, pain levels were also administered, as well manual dexterity assessment. Each group was matched with healthy controls by age, sex, mother tongue, education. No...
Background The effectiveness of botulinum neurotoxin type A (BTXA) injections in relieving the neck pain and reduced motion that evolve after whiplash injury (WI) has been controversial. Aim Study To test long-term efficacy a tender point injection BTXA patients with WI. Methods Twenty cervical myofascial pain, 2 to 48 weeks WI, were randomly assigned receive either 200 U or placebo at 4 points seen during follow-ups 3, 6, 9, 12, 24 injections. Outcome measures included intensity as...
<strong>Background:</strong> Our aim was to study the effects of visual feedback cues, responding dynamically patient's self-motion and provided through a portable seethrough virtual reality apparatus, on walking abilities patients with Parkinson's disease. <strong>Methods:</strong> Twenty participated. On-line residual speed stride length were measured. <strong>Results:</strong> Attaching device patient display turned off showed negligible effect about 2%. With on, 56% improved either their...
It is now reported that non-motor features, cognitive and affective problems, are becoming a major factor in essential tremor (ET). The aim of this study was to investigate the prevalence dysfunction ET prospectively follow-up changes subjects.Fifty-two persons over age 50 years were recruited from Movement Disorder Clinic. subjects underwent baseline neurological, cognitive, mood assessments repeat assessment 2 later.The mean 68 years, with an average onset 55.8 disease duration 11.7 years....
<strong>Background:</strong> It is now reported that non-motor features, cognitive and affective problems, are becoming a major factor in essential tremor (ET). The aim of this study was to investigate the prevalence dysfunction ET prospectively follow-up changes subjects. <strong>Methods:</strong> Fifty-two persons over age 50 years were recruited from Movement Disorder Clinic. subjects underwent baseline neurological, cognitive, mood assessments repeat assessment 2 later....
Objective The objective of this study was to evaluate the effect simultaneous bilateral intra-articular injection (IAI) methylprednisolone acetate (MPA) on hypothalamic-pituitary-adrenal axis in patients with knee osteoarthritis. Methods Nonselected symptomatic osteoarthritis had IAI 80 mg MPA at each (group 1). Just before and weeks 1, 2, 4, 6, 8 after it, 1 µg adrenocorticotropin hormone stimulation test. Age- sex-matched 60 hyaluronic acid 2) same protocol tests. Demographic, clinical,...
Our aim was to study the effects of visual feedback cues, responding dynamically patient's self-motion and provided through a portable see-through virtual reality apparatus, on walking abilities patients with Parkinson's disease.Twenty participated. On-line residual speed stride length were measured.Attaching device patient display turned off showed negligible effect about 2%. With on, 56% improved either their speed, or length, both, by over 20%. After removal, waiting for 15 minutes,...
Our knowledge about the association between vitiligo and Parkinson's disease (PD) is sparse. We sought to investigate bidirectional epidemiological PD.
QUESTIONS UNDER STUDY: In this work we wanted to evaluate the effect of intra-articular injection (IAI) at knee joint 1 ml Diprospan on hypothalamic-pituitary-adrenal (HPA) axis. METHODS: Consecutive patients attending rheumatology or orthopaedic clinic with osteoarthritic pain not responding satisfactorily medical and physical therapy were asked participate in our study. After consent, had ultrasound-guided IAI Diprospan, containing 2 mg betamethasone sodium phosphate 5 dipropionate....