A5034519305- Advanced Chemical Sensor Technologies
- Gas Sensing Nanomaterials and Sensors
- Pulmonary Hypertension Research and Treatments
- Biosensors and Analytical Detection
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Metabolomics and Mass Spectrometry Studies
- Renin-Angiotensin System Studies
- Analytical Chemistry and Sensors
- Analytical Chemistry and Chromatography
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Parkinson's Disease Mechanisms and Treatments
- Advanced biosensing and bioanalysis techniques
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular and Diving-Related Complications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Obstructive Sleep Apnea Research
- Mass Spectrometry Techniques and Applications
- Advanced Sensor and Control Systems
- Metal and Thin Film Mechanics
- Conducting polymers and applications
- Transplantation: Methods and Outcomes
- Nuclear Materials and Properties
- Chronic Obstructive Pulmonary Disease (COPD) Research
Owlstone Medical (United Kingdom)
2019-2022
Hypertension pulmonaire : physiopathologie et innovation thérapeutique
2020-2021
Inserm
2013-2021
Hôpital Marie Lannelongue
2016-2021
Université Paris-Saclay
2016-2021
Université Paris-Sud
2017-2019
Bicêtre Hospital
2018-2019
Assistance Publique – Hôpitaux de Paris
2017-2019
Technion – Israel Institute of Technology
2011-2018
Rambam Health Care Campus
2014
To the Editor: Detecting active tuberculosis (TB) remains a major global public health challenge [1]. The tuberculin skin test does not distinguish latent from TB [2]. interferon-γ release assays have similar limitations [3]. Acid-fast bacilli staining of sputum has high false-negative rate (up to 50%) [4]. Nucleic acid amplification tests (NAATs), such as GeneXpert MTB/RIF (Cepheid, Sunnyvale, CA, USA), are accurate but require good infrastructure and necessity obtain quality sample,...
Background: Excessive proliferation and apoptosis resistance in pulmonary vascular cells underlie remodeling arterial hypertension (PAH). Specific treatments for PAH exist, mostly targeting endothelial dysfunction, but high pressure still causes heart failure death. Pulmonary may be driven by metabolic reprogramming of to increase glutaminolysis glutamate production. The N -methyl- d -aspartate receptor (NMDAR), a major neuronal receptor, is also expressed on cells, its role unknown....
Rationale: Pulmonary arterial hypertension is a severe lethal cardiopulmonary disease. Loss of function mutations in KCNK3 (potassium channel subfamily K member 3) gene, which encodes an outward rectifier + channel, have been identified pulmonary patients. Objective: We demonstrated that dysfunction common to heritable and nonheritable experimental (PH). Finally, not functional mouse vasculature. Methods Results: Using CRISPR/Cas9 technology, we generated 94 bp out frame deletion exon 1...
Breath research has almost invariably focussed on the identification of endogenous volatile organic compounds (VOCs) as disease biomarkers. After five decades, a very limited number breath tests measuring VOCs is applied to clinic. In this perspective article, we explore some factors that may have contributed current lack clinical applications VOCs. We discuss potential pitfalls experimental design, analytical challenges, well considerations regarding biochemical pathways impinge application...
Pulmonary arterial hypertension (PAH) is a rare and deadly disease affecting roughly 15-60 people per million in Europe with poorly understood pathology. There are currently no diagnostic tools for early detection nor does curative treatment exist. The lipid composition of arteries lung tissue samples from human PAH control patients were investigated using matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry (IMS) combined time-of-flight secondary ion (TOF-SIMS)...
The ante-mortem diagnosis of Parkinson's disease (PD) still relies on clinical symptoms. Biomarkers could in principle be used for the early detection PD-related neuronal damage, but no validated, inexpensive, and simple biomarkers are available yet. Here we report breath-print presymptomatic PD rats, using a model with 50% lesion dopaminergic neurons substantia nigra. Exhaled breath was collected from 19 rats (10 lesioned 9 sham operated) analyzed organically functionalized carbon nanotube...
Background Sleep disordered breathing (SDB), characterized by nightly intermittent hypoxia, is associated with multiple pathophysiologic alterations that may adversely affect patients acute myocardial infarction (AMI). This prospective study investigated whether the metabolic perturbations SDB are present when these develop AMI and if they clinical outcomes. Methods We prospectively enrolled 180 patients. was defined as oxygen desaturation index (ODI) >5 events/hour based on a Watch Pat-100...
Early diagnosis of Parkinson's disease (PD) is important because it affects the choice therapy and subject to a relatively high degree error. In addition, early detection PD can potentially enable start neuroprotective before extensive loss dopaminergic neurons substantia nigra occurs. However, until now, studies for using volatile biomarkers sampled only treated medicated patients. Therefore, there great need evaluate untreated patients establishing real world screening diagnostic...
Chemical sensors based on programmable molecularly modified gold nanoparticles are tailored for the detection and discrimination between breathprint of irritable bowel syndrome (IBS) inflammatory diseases (IBD). The examined in both lab- real-world clinical conditions. results reveal a discriminative power accuracy 81% IBD IBS 75% Crohn's Colitis states.
Artificially intelligent nanoarray based on molecularly-modified gold nanoparticles is tailored for the detection of preeclampsia by noninvasive breathprint analysis. The diagnostic power under actual clinical conditions shows discrimination between and nonpreeclamptic pregnancy with an 84% accuracy, nonpregnant women 87% accuracy. As a service to our authors readers, this journal provides supporting information supplied authors. Such materials are peer reviewed may be re-organized online...
In this study, we explored the complex interactions between platelet-derived growth factor (PDGF) and N-methyl-d-aspartate receptor (NMDAR) their effect on excessive proliferation migration of smooth muscle cells leading to obstructed arteries in pulmonary arterial hypertension (PAH). We report lower expression glutamate NMDA-type subunit 2B (GluN2B), a composing NMDARs expected affect cell survival/proliferation artery (PASMCs), PAH patient lungs. PASMC exposure PDGF-BB stimulated immediate...
Trichloroethylene exposure is a major risk factor for pulmonary veno-occlusive disease. We demonstrated that trichloroethylene alters the endothelial barrier integrity, at least in part, through vascular (VE)-Cadherin internalisation, and suggested this mechanism may play role development of
Early diagnosis of Parkinson's disease (PD) is great importance due its progressive phenotype. Neuroprotective drugs could potentially slow down progression if used at early stages. Previously, we have reported an altered content volatile organic compounds (VOCs) in the breath rats following a 50% reduction striatal dopamine (DA) induced by 6-hydroxydopamine. We now report on difference breath-print and VOCs between with mild severe lesions DA neurons, serotonergic neuronal lesions,...
The presence of Ig deposits and tertiary lymphoid tissues (tLTs) connected to remodeled vessels in PAH lungs suggests neogenesis as a critical step maintaining immunity against local autoantigens. We searched for an immune signature the lung peripheral blood patients. T cell repertoire 26 patients with iPAH, hPAH or PVOD (11 transplanted) 24 controls were analyzed purified CD4+ cells after laser-microdissection perivascular tLTs. Genomic detection receptor (TCR) rearrangements by multiplex...
With the continued presence of COVID-19 worldwide, it has been a challenge for breath research community to progress with clinical studies and travel restrictions have also limited opportunities meet up, share ideas celebrate latest advances. The Breath Biopsy Conference 2021 offered chance catch up that researchers in able make these difficult times. Limited led many field look more closely at different methods collection contributed growing calls consistent standards how results are...