A5083196590- Neurotransmitter Receptor Influence on Behavior
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neurological disorders and treatments
- Treatment of Major Depression
- Nitric Oxide and Endothelin Effects
- Cholinesterase and Neurodegenerative Diseases
- Neuropeptides and Animal Physiology
- Nicotinic Acetylcholine Receptors Study
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Advanced Chemical Sensor Technologies
- Olfactory and Sensory Function Studies
- Electroconvulsive Therapy Studies
- Liver Disease and Transplantation
- Biochemical Analysis and Sensing Techniques
- Genetic Neurodegenerative Diseases
- Adipose Tissue and Metabolism
- Polyamine Metabolism and Applications
- Alzheimer's disease research and treatments
- Renal function and acid-base balance
- Hormonal and reproductive studies
- Electrolyte and hormonal disorders
- Sexual function and dysfunction studies
Rappaport Family Institute for Research in the Medical Sciences
2007-2022
Technion – Israel Institute of Technology
2011-2022
Family Research Institute
1988-2003
Parkinson's Foundation
2003
Foundation Center
2003
National Institutes of Health
1986-1998
National Institute of Neurological Disorders and Stroke
1986-1998
Naval Research Laboratory Information Technology Division
1998
Virginia Commonwealth University Medical Center
1990
Carmel Medical Center
1988
Rasagiline [N‐propargyl‐1R(+)‐aminoindan], was examined for its monoamine oxidase (MAO) A and B inhibitor activities in rats together with S(−)‐enantiomer (TVP 1022) the racemic compound (AGN‐1135) compared to selegiline (1‐deprenyl). The tissues that were studied MAO inhibition brain, liver small intestine. While rasagiline AGN1135 are highly potent selective irreversible inhibitors of vitro vivo , S(−) enantiomer is relatively inactive examined. IC 50 values rat brain activity by 4.43±0.92...
Abstract: A selective increase in content of iron the pars compacta substantia nigra has been implicated biochemical pathology Parkinson's disease. Iron is thought to induce oxidative stress by liberation oxygen free radicals from H 2 O . Because 6‐hydroxydopamine (6‐OHDA) nigrostriatal dopaminergic neuronal lesions via metal‐catalyzed radical formation, effect chelator desferrioxamine was investigated on 6‐OHDA‐induced neuron degeneration rat. Intracerebroventricular injection 6‐OHDA (250...
Abstract: Acute inhibition of monoamine oxidase B (MAO‐B) in the rat does not affect striatal dopamine (DA) metabolism, but chronic MAO‐B with deprenyl has been reported to increase release DA, as shown using vitro techniques. To see whether also causes an DA vivo, rats were treated for 21 days either (0.25 mg/kg), TVP‐1012 [ R (+)‐ N ‐propargyl‐1‐aminoindan mesylate; 0.05 irreversible inhibitor that is metabolized amphetamines, clorgyline (0.2 or saline (all doses once daily by subcutaneous...
The effects of the irreversible monoamine oxidase (MAO) inhibitors, AGN 1133, 1135 and (−)‐deprenyl, on tyramine noradrenaline responses uptake [ 3 H]‐metaraminol were investigated in isolated vas deferens rat. Uptake H]‐octopamine was compared mouse deferens. modification noradrenaline‐induced pressor by 1133 examined anaesthetized rats cats. (7.5 × 10 −6 m) greatly potentiated to rat Both (−)‐deprenyl inhibited selectively at concentrations above −3 m (which caused almost complete...
TV3326, [(N-propargyl-(3R) aminoindan-5-y1)-ethyl methyl carbamate] is a novel aminoindan derivative of the selective irreversible monoamine oxidase (MAO)-B inhibitor, rasagiline (N-propargyl-(1R)aminoindan), possessing both cholinesterase (ChE) and MAO-inhibitory activity. In doses 35-100 µmoles/kg administered orally to rats, it inhibits ChE by 25-40% antagonises scopolamine-induced impairments in spatial memory. After daily administration 75 for 2 weeks, TV3326 does not show any motor...
BOTH deprenyl and rasagiline (R(+)-N-propargyl-1–aminoindane mesylate), at a concentration of 1–1 μM, increased survival in vitro rat E14 mesencephalic dopaminergic neurons that had been primed with 10% serum for 1 2 h (p < 0.05). Rasagiline, but not deprenyl, also total neuronal (MAP2–positive) 0.05) Under serum-free conditions, rasagiline, retained its neuroprotective action on neurones. GABAergic were affected by either or rasagiline. Clorgyline, an MAO-A inhibitor, did exert any these...
Abstract: Nutritional iron deficiency induced in rats causes a selective reduction of [ 3 H]spiperone binding caudate nucleus. This effect can be reversed by supplementation vivo. The possibility that may involved the dopamine D 2 receptor was investigated examining various and noniron chelators on rat Iron 1, 10‐phenanthroline, 2,4,6‐tripyridyl‐ s ‐triazine, α,α′‐dipyridyl, desferrioxamine mesylate inhibited H]spiperone. inhibition 1,10‐phenanthroline noncompetitive reversible. In presence...
Rasagiline [R(+)-N-propargyl-1-aminoindane] is a selective irreversible inhibitor of MAO-B which not metabolised to amphetamine-like derivatives. Like deprenyl, when given rats in dose for inhibition MAO-B, it does affect striatal extracellular fluid dopamine levels, but administered chronically (21 days) increased microdialysate without reduction deaminated metabolites. Similarly rasagiline (10(-6)M) the percentage tyrosine hydroxylase positive cells primary culture rat fetal mesencephalic...
1. The pressor and heart rate response to angiotensin II, noradrenaline, isoprenaline, tyramine β-phenylethylamine were examined before after bile-duct ligation in conscious trained dogs. 2. II was markedly suppressed ligation, although responses noradrenaline the indirectly acting sympathomimetic amines only slightly reduced. 3. Bradycardia, drugs, tachycardia, unchanged ligation. 4. Refractoriness action of chronic present study is similar that reported previously by others patients with...
1. We have examined the effects of bile duct ligation on vascular and extravascular smooth muscle responsiveness to noradrenaline tyramine using isolated rat hindlimb perfusion, portal vein vas deferens preparations. 2. Bile reduced contractile responses extra-vascular muscle. 3. Exposure some salts caused a reduction in contractility. 4. This effect was dependent upon salt type concentration. 5. These studies vitro suggest that total peripheral resistance hypotension seen obstructive...
(Fig. 1) Cholemia per se (i.e. independent of parenchymal liver damage) causes a profound disturbance systemic hemodynamics. This includes decrease in total peripheral vascular resistance, and possible impairment left ventricular performance. These, turn, lead to effective blood volume, tendency hemorrhagic shock prerenal failure. Early the course cholemia , natriuretic effects bile salts circulation may aggravate hypovolemia. In marked contrast regional beds kidney brain constrict during ....
The ante-mortem diagnosis of Parkinson's disease (PD) still relies on clinical symptoms. Biomarkers could in principle be used for the early detection PD-related neuronal damage, but no validated, inexpensive, and simple biomarkers are available yet. Here we report breath-print presymptomatic PD rats, using a model with 50% lesion dopaminergic neurons substantia nigra. Exhaled breath was collected from 19 rats (10 lesioned 9 sham operated) analyzed organically functionalized carbon nanotube...