A5023980135- Ion-surface interactions and analysis
- Cultural Heritage Materials Analysis
- Mass Spectrometry Techniques and Applications
- Pigment Synthesis and Properties
- Spectroscopy Techniques in Biomedical and Chemical Research
- Conservation Techniques and Studies
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Integrated Circuits and Semiconductor Failure Analysis
- Identification and Quantification in Food
- Force Microscopy Techniques and Applications
- Spectroscopy and Chemometric Analyses
- Analytical chemistry methods development
- Dye analysis and toxicity
- Forensic Fingerprint Detection Methods
- Metal complexes synthesis and properties
- Laser-induced spectroscopy and plasma
- Cellular Mechanics and Interactions
- Nuclear Materials and Properties
- Face and Expression Recognition
- Synthesis and Biological Evaluation
- 3D Printing in Biomedical Research
- Metal and Thin Film Mechanics
- Diamond and Carbon-based Materials Research
- Click Chemistry and Applications
Maastricht University
2021-2025
Imaging Center
2021-2024
University of Nottingham
2015-2022
Pennsylvania State University
2020
Institut de Chimie des Substances Naturelles
2018-2020
Université Paris-Saclay
2018-2020
Centre National de la Recherche Scientifique
2018-2020
Université Paris-Sud
2018
University of Antwerp
2013
Imaging mass spectrometry (IMS) has become a powerful tool to characterize the spatial distribution of biomolecules in thin tissue sections. In case matrix-assisted laser desorption ionization (MALDI) IMS, homogeneous matrix deposition is critical produce high-quality ion images, and sublimation particular shown be an excellent method for imaging lipids. Matrix by is, however, completely solvent-free system, which ought prevent mixing analytes thought necessary successful MALDI. Using 3D...
Pulmonary arterial hypertension (PAH) is a rare and deadly disease affecting roughly 15-60 people per million in Europe with poorly understood pathology. There are currently no diagnostic tools for early detection nor does curative treatment exist. The lipid composition of arteries lung tissue samples from human PAH control patients were investigated using matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry (IMS) combined time-of-flight secondary ion (TOF-SIMS)...
In the field of cultural heritage, and more specifically in oil paintings, ability to unambiguously identify locate metal soaps is great interest for a better understanding painting degradation. Here, we demonstrate use Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) instrument capable tandem mass spectrometry imaging unambiguous identification localization lead cross sections samples old paintings at high spatial resolution. It shown that specific fragmentation pattern dictated by...
Advanced data analysis tools are crucial for the application of ToF-SIMS to biological samples. Here, we demonstrate that by using a training set approach principal components (PCA) can be performed on large 3D images neuronal cell cultures. The method readily provides access sample component information and significantly improves images' signal-to-noise ratio (SNR).
ToF-SIMS is increasingly used to analyze cultural heritage materials because it can simultaneously detect organic and inorganic while mapping them on a surface. The precise identification of pigment in specific layer painting or remaining color statue inform about the technique time manufacture as well expose possible forgeries when anachronistic ingredients are identified. Reference spectra required confidently identify given using ToF-SIMS. This database focuses eight lead-based historical...
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging is a surface analysis technique that identifies and spatially resolves the chemical composition of sample with lateral resolution less than 1 μm. Depth analyses can also be performed over thicknesses several microns. In case painting cross section, for example, TOF-SIMS identify organic composition, by detecting molecular ions fragments binders, as well mineral most pigments. Importantly, almost not destructive therefore...
ToF-SIMS is increasingly used to analyze cultural heritage materials because it can simultaneously detect organic and inorganic while mapping them on a surface. The precise identification of pigment in specific layer painting or remaining color statue inform about the technique time manufacture as well expose possible forgeries when anachronistic ingredients are identified. Reference spectra required confidently identify given using ToF-SIMS. This database focuses eight lead-based historical...
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is increasingly used to analyze cultural heritage materials because it can simultaneously detect organic and inorganic while mapping them on a surface. The precise identification of pigment in specific layer painting or remaining color statue inform about the technique time manufacture as well expose possible forgeries when anachronistic ingredients are identified. Reference spectra required confidently identify given using ToF-SIMS....
Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) imaging is a potent analytical tool that provides spatially resolved chemical information of surfaces at the microscale. However, hyperspectral nature ToF-SIMS datasets constitutes can be challenging to analyze and interpret. Both supervised unsupervised Machine Learning (ML) approaches are increasingly useful help data. Random Forest (RF) has emerged as robust powerful algorithm for processing mass spectrometry This machine learning...
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging is a potent analytical tool that provides spatially resolved chemical information on surfaces at the microscale. However, hyperspectral nature of ToF-SIMS datasets can be challenging to analyze and interpret. Both supervised unsupervised machine learning (ML) approaches are increasingly useful help data. Random Forest (RF) has emerged as robust powerful algorithm for processing This approach offers several advantages,...
Mass spectrometry imaging (MSI) is a technique that analyzes the chemical information and spatial distribution of surface analytes. Most MSI studies are conducted in microprobe mode, which mass spectrum collected for each pixel to create image. Thus, resolution, sample area, speed linked. In this halving size quadruples analytical time, presents practical limit on high resolution throughput. Fast microscopy (FMM) is, contrast, microscope-mode decouples speed. FMM circumvents linear-quadratic...
We report the synthesis and full characterisation of piano-stool triphenylstibine triphenylarsine arene complexes type: [MCl2(ƞ6-p-cymene)(EPh3)] (E = As, Sb) [MCl(ƞ6-arene)(EPh3)(SnCl3)] (M Ru, Os; E Sb; benzene, p-cymene); Ph C6H5) their in vitro cytotoxic evaluation on two breast cancer cell lines: MCF-7, MDA-MB-231 MCF-12A. The compounds were synthesized via a facile two-step reaction: first, cleavage corresponding dimer [(MCl2(ƞ6-arene))2] p-cymene) by either:AsPh3 or:SbPh3 to yield...
Abstract Skeletal stem cells (SSCs, or mesenchymal stromal typically referred to as from the bone marrow) are a dynamic progenitor population that can enter quiescence, self-renew differentiate depending on regenerative demand and cues their niche environment. However, ex vivo, in culture, they grown hard polystyrene surfaces, this leads rapid loss of SSC phenotype. While materials being developed control growth differentiation, very few examples interfaces reflect plastic nature have, date,...
Variants of the SLC24A5 gene, which encodes a putative potassium-dependent sodium–calcium exchanger (NCKX5) that most likely resides in melanosome or its precursor, affect pigmentation both humans and zebrafish (Danio rerio). This finding suggests genetic variations influencing human skin alter biogenesis via ionic changes. Gaining an understanding how changes environment organelles impact morphogenesis will require spatially resolved way to characterize chemical melanosomes pigmented tissue...
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is increasingly used to analyze cultural heritage materials because it can simultaneously detect organic and inorganic while mapping them on a surface. The precise identification of pigment in specific layer painting or remaining color statue inform about the technique time manufacture as well expose possible forgeries when anachronistic ingredients are identified. Reference spectra required confidently identify given using ToF-SIMS....
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is increasingly used to analyze cultural heritage materials because it can simultaneously detect organic and inorganic while mapping them on a surface. The precise identification of pigment in specific layer painting or remaining color statue inform about the technique time manufacture as well expose possible forgeries when anachronistic ingredients are identified. Reference spectra required confidently identify given using ToF-SIMS....
Mass spectrometry imaging (MSI) is a technique that analyzes chemical information and spatial distribution of surface analytes. Most MSI studies are conducted in microprobe-mode, which mass spectrum collected for each pixel to create image. Thus, resolution, sample area, speed linked. In this mode, halving the size quadruples analytical time, presents practical limit on high resolution throughput. Fast microscopy (FMM) is, contrast, microscope-mode decouples speed. FMM circumvents...
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is increasingly used to analyze cultural heritage materials because it can simultaneously detect organic and inorganic while mapping them on a surface. The precise identification of pigment in specific layer painting or remaining color statue inform about the technique time manufacture as well expose possible forgeries when anachronistic ingredients are identified. Reference spectra required confidently identify given using ToF-SIMS....
Certain objects and know-how have cultural significance in our societies, that is, they are inherited from a common past meant to be preserved passed down generation generation. These can works of art such as frescoes, paintings or jewelry, but also statues, ruins, everyday pottery, tools, remedies, cosmetics. All which testimony the skills technical knowledge societies. The expertise actions curators restorers play an important role this generational transmission heritage. chemical analysis...