A5050287510- Ethics in Clinical Research
- Health Systems, Economic Evaluations, Quality of Life
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Biomedical Ethics and Regulation
- Retinal Development and Disorders
- SARS-CoV-2 and COVID-19 Research
- Skin Diseases and Diabetes
- Chronic Kidney Disease and Diabetes
- Health Policy Implementation Science
- Dermatological and Skeletal Disorders
- Hepatitis B Virus Studies
- Ocular Oncology and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Angiogenesis and VEGF in Cancer
- Cerebrovascular and genetic disorders
- Autism Spectrum Disorder Research
- Retinal Imaging and Analysis
- Retinopathy of Prematurity Studies
- CNS Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Polyomavirus and related diseases
Lemuel Shattuck Hospital
2022-2024
Harvard University
2017-2024
Massachusetts General Hospital
2022-2024
University of Louisiana at Lafayette
2024
Yale University
2022
Center for Systems Biology
2022
Massachusetts Eye and Ear Infirmary
2017-2020
Smith-Kettlewell Eye Research Institute
2017-2020
Research Institute Hospital 12 de Octubre
2003
Abstract The Omicron variant of SARS-CoV-2 recently swept the globe and showed high level immune evasion. Here, we generate an Omicron-specific lipid nanoparticle (LNP) mRNA vaccine candidate, test its activity in animals, both alone as a heterologous booster to WT vaccine. Our LNP-mRNA elicits strong antibody response vaccination-naïve mice. Mice that received two-dose show > 40-fold reduction neutralization potency against than two weeks post boost, which further reduce background after...
Proliferative diabetic retinopathy (PDR) is a common cause of blindness in the developed world’s working adult population and affects those with type 1 2 diabetes. We identified Runt-related transcription factor (RUNX1) as gene upregulated CD31+ vascular endothelial cells obtained from human PDR fibrovascular membranes (FVMs) via transcriptomic analysis. In vitro studies using retinal microvascular (HRMECs) showed increased RUNX1 RNA protein expression response to high glucose, whereas...
Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a neurological syndrome characterized by small vessel disease (SVD), stroke, vascular cognitive impairment dementia caused mutations in NOTCH3 No therapies are available for this condition. Loss of mural cells, which encompass pericytes smooth muscle hallmark CADASIL other SVDs, including diabetic retinopathy, resulting instability. Here, we showed that Notch3 signaling both necessary...
Population reflective research enrollment improves study generalizability and disease knowledge. Nevertheless, the proportion of underrepresented groups (URGs) in Parkinson's (PD) remains low. Hence, current manuscript describes process designing a to analyze effectiveness strategies overcome barriers URG recruitment PD research. The Fostering Inclusivity Research Engagement for Underrepresented Populations Disease (FIRE-UP PD) asked participating sites identify or geographical region target...
We report a 84‐year‐old man with 13‐year history of recurrent generalized asymptomatic pustular lesions. Histology revealed areas necrobiosis surrounded by palisading granulomas and transepidermal follicular elimination the necrobiotic material. A dense infiltrate neutrophils was also found. Although 26% patients perforating granuloma annulare have some yellow pustule‐like papules, these correspond histologically to viscous material extruding through epidermis not real neutrophilic...
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has high transmissibility and recently swept the globe. Due to extensive number mutations, this level immune evasion, which drastically reduced efficacy existing antibodies vaccines. Thus, it is important test an Omicron-specific vaccine, evaluate its response against other variants, compare immunogenicity as boosters with vaccine designed reference wildtype virus (WT). Here, we generated lipid nanoparticle...
Acute orbital inflammation can lead to irreversible vision loss in serious cases. Treatment thus far has been limited systemic steroids or surgical decompression of the orbit. An animal model that mimics characteristic features acute as found thyroid eye disease be used explore novel treatment modalities.We developed a murine by injecting oxazolone into mouse The mice underwent magnetic resonance imaging (MRI) and were euthanized at various time points for histologic examination....
Despite federal regulations mandating the inclusion of underrepresented groups in research, recruiting diverse participants remains challenging. Identifying and implementing solutions to recruitment barriers real time might increase participation groups. Hence, present study created a comprehensive dashboard research participation. Barriers were recorded for prospective participants. Overall, 230 expressed interest but unable join due one or more barriers. Awareness most common obstacles...
Members of vulnerable populations are underrepresented in Parkinson's disease (PD) research. A complex web research barriers perpetuates this gap. Community-based methods one approach to addressing issue. The present PD study was designed examine the effectiveness community-based interventions overcome and increase participation among groups (URGs).
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