A5033426760- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Glycogen Storage Diseases and Myoclonus
- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Transcranial Magnetic Stimulation Studies
- Autism Spectrum Disorder Research
- Neuroscience and Neural Engineering
- Parkinson's Disease and Spinal Disorders
- Obsessive-Compulsive Spectrum Disorders
- Neurogenetic and Muscular Disorders Research
- Congenital heart defects research
- Genomics and Rare Diseases
- Neurological and metabolic disorders
- Vagus Nerve Stimulation Research
- Tracheal and airway disorders
- Music and Audio Processing
University of Florida
2012-2024
Florida College
2008-2021
University of Florida Health
2021
UF Health Shands Hospital
2011
Neurology, Inc
2010
Allen Institute for Brain Science
2008
OBJECTIVE To examine a case series of reoperations for deep brain stimulation (DBS) leads in which clinical scenarios revealed suboptimal outcome from previous operation. Suboptimally placed DBS are one potential reason unsatisfactory results after surgery Parkinson's disease (PD), essential tremor (ET), or dystonia. In study patients who experienced results, 19 41 had misplaced leads. Similarly, another report commented that lead placement beyond 2- to 3-mm window resulted inadequate...
<h3>Objective</h3> To assess longitudinal tremor outcomes with ventral intermediate nucleus deep brain stimulation (VIM DBS) in patients dystonic (DT) and to compare DBS essential (ET). <h3>Methods</h3> We retrospectively investigated VIM for 163 followed at our center diagnosed either DT or ET. The Fahn-Tolosa-Marin rating scale (TRS) was used change activities of daily living (ADL) 6 months, 1 year, 2–3 years, 4–5 ≥6 years after surgery. <h3>Results</h3> Twenty-six 97 ET were analyzed....
Orthostatic tremor (OT) is a disabling movement disorder associated with postural and gait impairment in the elderly. Medical therapy often yields insufficient benefit. We report clinical electrophysiological data on two patients medication-refractory OT treated deep brain stimulation of ventral intermediate thalamic nucleus (Vim DBS). Patient 1 underwent bilateral (DBS) 2 unilateral Vim DBS following 28 30 years disease duration, respectively. Both showed increased latency to symptom onset...
In this paper, the authors' aim was to examine reasons underpinning decisions undergo, or alternatively forgo, a second-sided deep brain stimulation (DBS) implantation in patients with Parkinson disease (PD).Fifty-two (PD) were randomized receive DBS subthalamic nucleus globus pallidus internus (GPi) as part of COMPARE trial. Forty-four had complete data sets. All offered choice at 6 months after unilateral whether contralateral implant. advanced PD. The mean patient age 59.8 years (range...
ADCY5 mutations have been reported as a cause of early onset hyperkinetic movements associated with delayed motor milestones, hypotonia, and exacerbation during sleep. The movement disorder may be continuous or episodic, can vary considerably in severity within families individuals. authors report case series 3 patients treated deep brain stimulation after unsuccessful medication trials. All had extensive imaging, metabolic, genetic testing prior to confirmation their mutation. Two the...
Huntington’s disease (HD) is an autosomal dominant and progressive neurodegenerative syndrome characterized by motor, cognitive psychiatric manifestations. Chorea dystonia are features that may be troublesome to some patients potentially prove unresponsive pharmacological treatments. There several reports on the results of globus pallidus internus deep brain stimulation (DBS) surgery for HD. In these published cases, DBS was utilized mainly treat disabling chorea. We report our experience...
Objective To describe three DBS cases which presented with new side effects or loss of benefit from stimulation after long-term follow-up and to discuss the potential contributing factors. Methods A University Florida (UF) database (INFORM) search was performed, identifying patients, two Parkinson's disease (PD) one Essential Tremor (ET), an unexpected change in programming thresholds as compared initial evaluation. Clinical follow-up, programming, imaging studies, lead measurements were...
ABSTRACT Objectives The aim of this study is to identify anatomical regions related stimulation‐induced dyskinesia (SID) after pallidal deep brain stimulation (DBS) in Parkinson's disease (PD) patients and analyze connectivity associated with SID. Methods This retrospective analyzed the clinical imaging data PD who experienced SID during monopolar review DBS. We structural functional using normative volume tissue activated (VTA) modeling. Each contact was assigned either that producing (SID...
The travel required to receive deep brain stimulation (DBS) programming causes substantial burden on patients and limits who can access DBS therapy.To evaluate the efficacy of home health postoperative management in an effort reduce improve access.This open-label randomized clinical trial was conducted at University Florida Health from November 2017 April 2020. Eligible participants had a diagnosis Parkinson disease (PD) were scheduled independently study. Consenting 1:1 either standard care...
The purpose of this paper is to present 4 cases that illustrate the management and outcome subdural hematoma (SDH) following deep brain stimulation (DBS) lead implantation.The authors identified SDH DBS implantation from a pool 500 consecutive implantations (incidence 0.08%) performed at University Florida. Cases were characterized by chart review, serial Unified Parkinson's Disease Rating Scale evaluations, changes on postoperative imaging studies.Two patients with DBS-related clinically...
Introduction: Advances in neuromodulation and deep brain stimulation (DBS) technologies have facilitated opportunities for improved clinical benefit side effect management. However, new added complexity to clinic-based DBS programming.Areas covered: In this article, we review basic basal ganglia physiology, proposed mechanisms of action technical aspects DBS. We discuss novel movement disorders including the role advanced imaging software, lead design, IPG programming techniques directional...
Deep brain stimulation has been utilized in both dystonia and medication refractory Tourette syndrome. We present an interesting case of a patient with mixture disabling syndrome whose coexistent tics were successfully treated 60 Hz-stimulation the globus pallidus region.
<strong>Background:</strong> It has been observed that low-frequency stimulation (LFS) may be effective for dystonia, and the use of LFS alleviate need frequent battery changes in a subset patients. The aim this study was to analyze as strategy treat deep brain (DBS) patients with various dystonias. <strong>Methods:</strong> Subjects had receive minimum 6 months clinical follow-up at University Florida, were required have 3 on trial. Twenty-seven dystonia DBS retrospectively analyzed from...