A5013063826- Neurological Disorders and Treatments
- Myofascial pain diagnosis and treatment
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Pain Mechanisms and Treatments
- Nicotinic Acetylcholine Receptors Study
- Vestibular and auditory disorders
- Cholinesterase and Neurodegenerative Diseases
- Cerebrovascular and Carotid Artery Diseases
- Nerve Injury and Rehabilitation
- Sleep and Wakefulness Research
- Cervical and Thoracic Myelopathy
- Nerve injury and regeneration
- Migraine and Headache Studies
- Pain Management and Treatment
- Long-Term Effects of COVID-19
- Dementia and Cognitive Impairment Research
- Acute Ischemic Stroke Management
- Peripheral Nerve Disorders
- Cancer Treatment and Pharmacology
- Pain Management and Placebo Effect
- Spinal Fractures and Fixation Techniques
- Pharmacology and Obesity Treatment
S. M. Kirov Military Medical Academy
2016-2025
Saint Petersburg State Pediatric Medical University
2018
Military Medical Academy
2012-2013
Objective. To present the recommendations of expert council Russian Society for Study Pain on “Dorsumio” drug in treatment chronic nonspecific back pain (CNBP). Key points. Currently, CNBP is leading disease associated with disability worldwide. Patients often experience concomitant depressive and anxiety symptoms complicating course therapy, as well worsening quality life working capacity. Various problems care include not only impact pathogenesis pain, but also depression, anxiety,...
Obtaining additional data on the efficacy and safety of drug Prospekta in treatment moderate cognitive impairment (MCI) asthenia patients with cerebrovascular disease (CVD).A prospective observational study more than 40 Russian cities enrolled 232 (mean age 61.5±10.0 years) mild (MCI), ongoing basic nootropic therapy. The presence MCI was confirmed by Montreal Cognitive Assessment Scale (MoCA), - 10-point Visual Analog (VAS). All were prescribed medication 2 tablets times a day for 8 weeks...
The resolution of the expert council is devoted to discussing aspects use ipidacrine for treatment mononeuropathies, polyneuropathies and radiculopathies various etiologies. Specialists prepared recommendations ipidacrine's application in treating peripheral nervous system disorders.
The current studies describing magnetic stimulation for treatment of nervous system diseases mainly focus on transcranial and rarely spinal cord stimulation. Spinal has been confirmed to promote neural plasticity after injuries cord, brain peripheral nerve. To evaluate the effects impulse nerve regneration, we compressed a 3 mm segment located in middle third hip using sterilized artery forceps induce ischemia. Then, all animals underwent lumbar portion crod roots daily 1 month. Electron...
Tension-type headache (TTH) is the most prevalent primary headache. Every year, about 2–3% of patients with TTH progress to chronic daily or near-daily headache, warranting preventive treatment. The treatment complex and very often associated significant tolerability issues. To date, melatonin has been studied in only a few small uncontrolled trials. aim this surveillance program was evaluate efficacy (Melaxen®) disruption circadian rhythms real-world practice. Sixty-one were enrolled. After...
The use of slow-acting disease-modifying symptomatic drugs, such as bioactive concentrate from small marine fish (BCSMF, Alflutop), is considered a potential element complex therapy for chronic non-specific back pain (CNBP). Objective : to evaluate the efficacy BCSMF in patients with CNBP real-life clinical practice. Material and methods . An open observational study included 10,047 (age – 58.3±14.9 years, 58.4% women) moderate or severe 60 [50; 70] mm on visual analogue scale (VAS). All...
To analyze the effect of Alflutop on neuroinflammation in patients with chronic lower back pain (CBP).Forty-one a verified CBP diagnosis were enrolled study. was used for treating CBP, 1 ml once/day, 20 days. Treatment efficacy monitored using Visual Analogue Scale (VAS), DN4 test; Roland-Morris questionnaire; index activity lumbar spine; and level tumor necrosis factor-α (TNF-α) blood plasma. There three visits total: screening (visit 0), treatment start 1, 0-3 days after screening) visit 2...
Back pain ranks first among all non-communicable diseases in terms of the number years life lost due to poor health. At same time, choice tactics for treatment dorsopathies presents certain difficulties, particular, a nonsteroidal anti-inflammatory drug (NSAID), which depends on factors. NSAIDs are effectively used musculoskeletal pain, but they have side effects, determines individual characteristics their use. The article an overview scientific data published sources MEDLINE, PubMed,...
The article presents modern ideas about the pathogenesis of cognitive disorders in cerebrovascular pathology at cellular level. Dysfunction neurovascular units is associated with impaired microcirculation, hypoxia, deficiency energy resources, development neuroinflammation, increased nitric oxide synthesis and oxidative stress, glutamate excitotoxicity, intracellular calcium accumulation, endothelial dysfunction, circulation fluid, venous outflow from cranial cavity utilization brain...
Complaints of dizziness are common in patients diagnosed with chronic cerebrovascular insufficiency (CCVI). Effective therapy these is one the most urgent problems outpatient neurological practice. Objective: to evaluate efficiency and safety long-term administration vinpocetine (Cavinton Comforte) treatment CCVI. Patients methods . A total 139 took part an open-label parallel-group clinical study. Vinpocetine vestibular exercises were prescribed Group 1 (n=69); used 2 (n=70). The was...
To analyze the spinal mechanisms of neuroplastic changes induced by neuromidin (ipidacrine) in a model traumatic axonotomy sciatic nerve rats.The histological study material from anterior horn (lumbar portion cord) was performed 6 rats using electron microscopy.The comparative analysis neuromorphological control and main groups revealed neuroprotective modifying effects on neuroplasticity.Цель исследования. Анализ спинальных нейропластических механизмов, индуцированных применением...
Deficiency of vitamin B12 occurs much more often than it is commonly believed and leads to a wide range various disorders, the emergence primarily neurological manifestations, while there lack awareness among clinicians in field its causes, nonspecific diagnostic methods effective therapy. The conference «The problem deficiency experience use Germany» was devoted this urgent clinical problem, within framework which an interdisciplinary council experts, at most pressing issues were...
Evaluation of Alfultop impact on nociceptive afferentation central mechanisms in patients with chronic lower back pain.The study involved 40 CLBP. The therapy included Alflutop, 2 ml once a day for 10 days. Mean VAS-pain, LANSS, Roland-Morris questionnaire, Global Rating Change Scale (GRC), pressure pain thresholds data were analyzed. Follow-up duration was 3 months.Most the females (f:m=1.3:1); average age - 60.5 [54.2; 67.3] years mean disease 14.3±4.2 mo. At visit 1, VAS score 63.2±9.4,...
Traumatic injuries of peripheral nerves are caused by domestic, iatrogenic, industrial or military injuries. The estimated frequency traumatic neuropathies in peacetime Europe is 1 per 1000, with the highest prevalence among young people working age. In modern local armed conflicts, and severity gunshot increased significantly. connection widespread use personal protective equipment (helmet, body armor), there a relative increase to limbs. Damage nerve can significantly reduce patient’s...
Study objective — To evaluate how morphological features of intervertebral disc would affect the outcomes finite element modeling axial load in cervical spine, C3-C5, order to predict risk occurrence and course dorsopathies. Material Methods Three-dimensional models spine vertebrae were generated from computed tomography data a volunteer (24 years old male without detected pathology his neck). Intervertebral developed two configurations. For each model, we performed investigation...
To evaluate the cognitive changes in patients with mild to moderate Alzheimer's disease after treatment acetylcholinesterase inhibitors - neuromidin and galantamine.Fifty-eight probable disease, aged 60-84 years (mean 73.2±6.7), were enrolled a 20-week double-blind parallel group study. All randomized 2 groups: 1 (n=28) received neuromidin, (n=30) galantamine. Treatment efficacy was evaluated ADAS-cog/11 scale.Both drugs significantly improved or stabilized function patients. The most marked...
To investigate the efficacy of divaza in outpatients with cognitive disorders and chronic brain ischemia (CBI).The non-interventional observational program included data 2583 CBI from 30 cities (8 federal okrugs Russian Federation) who were on outpatient neurological treatment received a dose 2 tablets three times day Oct 2016 to Jan 2017. Cognitive functions evaluated using MoCA scale before after 3 months treatment.Cognitive identified 90.7% patients (<26 scores). After treatment, mean...
The paper presents the proceedings of Round Table with participation leading neurologists, which is devoted to chronic cerebrovascular diseases. It noted that cerebral ischemia (CCI), or dyscirculatory encephalopathy (DEP), one most common neurological diagnoses in our country. pathogenesis, clinical presentations, diagnosis and treatment CCI (DEP) its matching vascular cognitive impairment (CI), regarded foreign literature as main manifestation disease (CVD) were considered. authors analyze...
A comparative analysis of the clinical efficacy cholinergic drugs and acetylcholinesterase inhibitors (IHE), as well their combination, in treatment cerebrovascular disease consequences intracranial injury according to clinical, instrumental laboratory dynamic observations.Ninety patients with pathology, including 45 chronic brain ischemia stage 2 (ICD-10 I67) sequelae T90.5), were enrolled study. Complex included basic specific therapy. The groups divided into 3 subgroups 15 people:...
To perform a comparative analysis of the efficacy original drug meloxicam (movalis) and its generic (amelotex) in treatment patients with lower back pain.The results 112 (61 men 51 women) employees JSC «Admiralteyskie Verfi», aged 18 to 60 years, was carried out. All these were treated period from 2015 2017 at Medical Center Verfi» due dorsalgia lumbosacral localization (ICD-10, item M54). The average age 42,6±10,4 (from 22 59 years). Age range 20-35 years (n=34); 36-50 (n=49); >50...
To improve the algorithm of differential diagnosis and complex treatment patients with CR.Forty-two CR were divided into 2 groups. Patients first group (n=21) received basic (NSAID, myorelaxants, local injections glucocorticoids (on demand), B vitamins non-pharmacological methods) anticholinesterase drug ipidacrine. The second had only treatment. total duration study was 45 days. effectiveness evaluated VAS, NDI, GROC disability period.A battery tests for that included Spurling test, motor...
Stroke was and remains one of the world's leading medical social problems. Nowadays we are watching permanent sometimes cardinal changes in view about etiology, pathogenetic mechanisms therapy patients with stroke. In this work there have been elucidated contemporary theoretical practical aspects stroke treatment prophylaxis based on results multicenter clinical trials experience foreign native specialists. Much attention is devoted to pharmacotherapy It showed that application...
Introduction. In the structure of global burden diseases, back pain ranks first in world list causes disability. Neck is one most common diseases musculoskeletal system. An integral part strategy for treatment acute neck use original nonsteroidal anti-inflammatory drugs (NSAIDs) with high proven effectiveness. Objective . To conduct a comparative analysis therapeutic efficacy drug meloxicam (Movalis) and its generic (Amelotex) patients nonspecific cervical localization. Materials methods....