A5102767346- Multiple Sclerosis Research Studies
- Neurological Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Peripheral Neuropathies and Disorders
- Neurological Disease Mechanisms and Treatments
- Muscle Physiology and Disorders
- Botulinum Toxin and Related Neurological Disorders
- Polyomavirus and related diseases
- Cerebral Palsy and Movement Disorders
- Human Health and Disease
- Acute Ischemic Stroke Management
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Fusion and Plasma Physics Studies
- S100 Proteins and Annexins
- Myofascial pain diagnosis and treatment
- Intracranial Aneurysms: Treatment and Complications
- Medical and Biological Sciences
- Neurogenetic and Muscular Disorders Research
- Healthcare Systems and Public Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Stroke Rehabilitation and Recovery
- Cerebral Venous Sinus Thrombosis
- Parkinson's Disease Mechanisms and Treatments
- Rheumatoid Arthritis Research and Therapies
First Pavlov State Medical University of St. Petersburg
2008-2023
Saint Petersburg State Pediatric Medical University
2019
City Clinical Hospital No 31
2016
Kazan State Medical University
2015
Rostov State Medical University
2015
Kazan State Medical Academy
2015
Ural State Medical University
2015
Krasnoyarsk State Medical University
2015
Yaroslavl State Medical Academy
2015
Ministry of Health of the Russian Federation
2015
Stroke is a multisystemic disorder that includes mechanisms of thrombosis and neurotoxic coupling. Key metabolites the molecular cascade following biochemical events appear simultaneously in brain tissue, blood-brain barrier, vessels, activating immune system generating autoantibodies (aAbs) to brain-specific antigens. We developed an ELISA blood test measure aAbs subtype N-methyl-D-aspartate (NMDA) receptors, which are key markers neurotoxicity underlying cerebral ischemia. investigated...
To assess safety, tolerability, and efficacy of the antigen-specific immunotherapy ATX-MS-1467 in participants with relapsing multiple sclerosis using different treatment protocols to induce tolerance.Two open-label trials adult were conducted. Study 1 was a multicenter, phase 1b safety evaluation comparing intradermal (i.d.) (cohort 1) subcutaneous 2) administration 43 participants. Both cohorts received dosed at 25, 50, 100, 400, 800 μg 14-day intervals over 8 weeks, followed by weeks 4...
Leptomeningeal contrast enhancement (LMCE) on magnetic resonance imaging (MRI) is a newly recognized possible biomarker in multiple sclerosis (MS), associated with MS progression and cortical atrophy. In this study, we aimed to assess the prevalence of LMCE foci their impact neurodegeneration disability. Materials. 54 patients were included study. detected 3 Tesla scanner postcontrast fluid-attenuated inversion-recovery (FLAIR) sequence. Expanded Disability Status Scale (EDSS) score, number...
Obtaining additional data on the efficacy and safety of drug Prospekta in treatment moderate cognitive impairment (MCI) asthenia patients with cerebrovascular disease (CVD).A prospective observational study more than 40 Russian cities enrolled 232 (mean age 61.5±10.0 years) mild (MCI), ongoing basic nootropic therapy. The presence MCI was confirmed by Montreal Cognitive Assessment Scale (MoCA), - 10-point Visual Analog (VAS). All were prescribed medication 2 tablets times a day for 8 weeks...
The prospective multicenter open noncomparative pharmaco-epidemiological observational project on the use of mydocalm in real clinical practice has been completed 2013. performed 2090 clinical/rehabilitation settings 284 cities 13 countries using results 35,383 patients. aimed to assess safety treatment (percentage patients with adverse-effects) and pain relieving efficacy as well patient's satisfaction treatment. In total, 6603 (19%) adverse-effects were recorded. Their severity was...
There is an increase in the incidence of multiple sclerosis world. Only half cases, standard therapy allows for a short time to achieve control over this disease. High-dose immunosuppressive and autologous hematopoietic stem cells transplantation promising effective method treating autoimmune diseases, including scler ovsis. Over past 20 years, progress has been made understanding immune mechanisms method. At present, frequency severity adverse events significantly decreased by reducing...
Introduction. Multiple sclerosis (MS) is a chronic autoimmune and neurodegenerative disease of the central nervous system (CNS). High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation (HDIT–AHSCT) most eff ective method treating MS, which has positive ect on quality life patients inhibition progression disability. The aim study was to analyze dynamics in MS who underwent HDIT– AHSCT groups diff erent clinical effi cacy this method. Material methods....
Objective: To assess the efficacy of Clostridium botulinum type A toxin-hemagglutinin complex [BoNT-A, Dysport®] in treatment adults with adductor muscle spasticity due to definite or probable multiple sclerosis [MS].
Botulinum toxin (BoNT) injections were shown to improve muscle tone of limbs in patients with spasticity. However, limited data are available regarding the effects repeated BoNT on walking ability.To assess changes velocity (WV), step length, and cadence under different test conditions after treatment abobotulinumtoxinA (aboBoNT-A; Dysport) spastic lower limb muscles.Secondary analysis an open-label, multiple-cycle extension (National Clinical Trials number NCT01251367) a phase III,...
Recurrent episodes of vertigo are one the most frequent reasons referrals for medical help. In Russian medicine, development is traditionally associated with a cerebral vascular pathology. It suggested that correctly planned clinical neurovestibular study may identify signs balance disorder peripheral and central genesis.To increase effectiveness differential diagnosis in patients recurrent disorders using protocol examination ALGORITM.The included 120 outpatients preliminary diagnoses...
To evaluate the diagnostic value of determination free immunoglobulin light chains (IgG) in debut multiple sclerosis (MS).Data from 226 patients, including 111 patients with clinically isolated syndrome conversion to within first 2 years disease (group 1), 49 who did not develop 2), 20 other inflammatory diseases central nervous system 3) were analyzed. The control group consisted 46 non-inflammatory system. clonality immunoglobulins CSF, concentration kappa and lambda their ratio...
To assess the efficacy and safety of drug ampasse in treatment patients with chronic cerebrovascular disorders (CCVD).A multicenter, randomized, double-blind, placebo-controlled, confirmatory study (phase III) was conducted 124 aged 50 to 75 years. The main group (MG) - 62 patients, received test ampasse, solution for intravenous administration, 5 mg/ml, at a dose ml (25 mg), intravenously bolus slowly, duration 15 days. Control (CG) comparison drug: placebo (0.9% sodium chloride-5 ml).All...
We studied patients with dystonia (D) and essential tremor (ET) using positron emission tomography (PET) equipped Cortex ID software. This allowed PET brain visualisation to be compared scans of a control group by means the z-score. The study revealed hypo-metabolism in both D ET groups, additionally difference between these two groups certain areas brain. These nosological forms overlap clinical features are difficult differentiate. picture may help provide differential diagnosis addition...
Introduction. High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation (HDIT/AHSCT) is a promising and effective method for treating immune disorders, including multiple sclerosis (MS). The frequency severity of adverse effects from have decreased significantly over the last 20 years due to reduction in conditioning regimen intensity, changes patient selection, accumulated experience centres.
 Study aim: analyse published data on HDIT/AHSCT...
Introduction. In 2018–2020, a study was conducted in the Russian Federation on efficacy and safety of highdose immunosuppressive therapy with autologous hematopoietic stem cell transplantation (HDIT-AHSCT) multiple sclerosis (MS). The aim to analyze preliminary data effectiveness HDIT-AHSCT patients MS who participated clinical approbation method. Material methods. 21 were included single-center Pavlov University (Saint Petersburg) observational study. 10 (47.6%) Expanded Disability Status...
To analyze the usage and timeliness of aquaporin-4 antibodies (AQP4-IgG) serology test in diagnostics neuromyelitis optica spectrum disorders (NMOSD) routine clinical practice.27 patients with NMOSD were included study. All had a positive serum for AQP4-IgG. A retrospective study neurological manisfestations attacks, timing results AQP4-IgG was performed. The analyzed taking into account two types attacks identified: a) HS (with highly specific manifestations NMOSD), which are considered as...
Five hundred and eight (508) patients (280 males 228 females, at age from 28 till 78 years old) suffered amyotrophic lateral sclerosis (ALS) or atypical form of ALS have passed brain magnetic resonance imaging (MRI) 2002 2012. We revealed classical in 423 patients, primary lateral (PLS) 8 progressive bulbar palsy (PBP) – 65 muscular atrophy (PMA) – 12 patients. MRI was performed different stages diseasefrom 1 7 since appearing first symptoms. In 49 (9,7%) we revealed T2 hyperintensive...
Objective: Budget impact analysis of teriflunomide inclusion as first-line disease modifying drugs (DMD) therapy in the List to ensure patients with relapsing-remitting multiple sclerosis (RRMS) within programme '7 high-cost nosologies' on budgets Russian Federation (RF) federal and regional public authorities field health care.Methods: was carried out from perspective RF, time horizon analysis: 5 years (treatment costs) 2 (effectiveness).Population RRMS RF.Data clinical effectiveness taken...
This article expounds the history of formation and development neurology in St. Petersburg emphasizes original character school neurology. The authors state that many prominent neurologists dedicated their work to neurological concepts have made an important contribution different areas neurology, including vascular demyelinating diseases, diseases peripheral nervous system, neuroinfections, epilepsy, etc.