A5061563180- Multiple Sclerosis Research Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Peripheral Neuropathies and Disorders
- Rheumatoid Arthritis Research and Therapies
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Systemic Sclerosis and Related Diseases
- Human Health and Disease
- Cytokine Signaling Pathways and Interactions
- Vitamin D Research Studies
- Biomarkers in Disease Mechanisms
- Polyomavirus and related diseases
- S100 Proteins and Annexins
- Neurological Disorders and Treatments
- Cell Adhesion Molecules Research
- Viral Infections and Immunology Research
- T-cell and B-cell Immunology
- Medical and Biological Ozone Research
- Effects of Radiation Exposure
- Traumatic Brain Injury and Neurovascular Disturbances
- Endometriosis Research and Treatment
- Medicinal Plants and Bioactive Compounds
- Immunotoxicology and immune responses
- Menopause: Health Impacts and Treatments
- RNA regulation and disease
Altai State Medical University
2015-2024
Regional State Budget Health Care Institution "Regional Clinical Hospital"
2018-2024
Kazan State Medical Academy
2019
University of Wolverhampton
2016
University of Tyumen
2016
Regional Public Health Care Institution "City Hospital No. 5, Barnaul"
2012
To evaluate the efficacy and safety of anti-CD20 monoclonal antibody divozilimab (DIV) used as an intravenous infusion at a dose 500 mg every 24 weeks during 100 for treatment patients with multiple sclerosis (MS), including relapsing-remitting (RRMS) secondary progressive MS (SPMS) relapses.
<h3>Objective</h3> A recent large-scale study in multiple sclerosis (MS) using the ImmunoChip platform reported on 11 loci that showed suggestive genetic association with MS. Additional data sufficiently sized and independent sets are needed to assess whether these represent genuine MS risk factors. <h3>Methods</h3> The lead SNPs of all were genotyped 10 796 cases 793 controls from Germany, Spain, France, Netherlands, Austria Russia, previously cohorts. Association analyses performed...
Multiple sclerosis (MS) is a serious, incurable neurological disease. In 2009, the ANZgene studies detected suggestive association of located upstream CD40 gene in chromosome 20q13 (p = 1.3×10−7). Identification causal variant(s) locus leads to better understanding mechanism underlying development autoimmune pathologies. We determined genotypes rs6074022, rs1883832, rs1535045, and rs11086996 patients with MS (n 1684) control group 879). Two SNPs were significantly associated MS: rs6074022...
Obtaining additional data on the efficacy and safety of drug Prospekta in treatment moderate cognitive impairment (MCI) asthenia patients with cerebrovascular disease (CVD).A prospective observational study more than 40 Russian cities enrolled 232 (mean age 61.5±10.0 years) mild (MCI), ongoing basic nootropic therapy. The presence MCI was confirmed by Montreal Cognitive Assessment Scale (MoCA), - 10-point Visual Analog (VAS). All were prescribed medication 2 tablets times a day for 8 weeks...
To find the optimal therapeutic dose of anti-B cell mAb divozilimab (DIV) based on efficacy and safety data intravenous administration at a 125 mg or 500 in patients with relapsing remitting multiple sclerosis (RRMS) compared to placebo (PBO) teriflunomide (TRF). study DIV within 24 weeks treatment.A multicenter, randomized, double-blind double-masked, placebo-controlled phase 2 clinical trial (CT) BCD-132-2 involved 271 adult RRMS from 25 centres In Russia. Patients were randomly assigned...
To evaluate the efficacy and safety of anti-CD20 monoclonal antibody divozilimab (DIV) used as an intravenous infusion at a dose 500 mg for treatment patients with relapsing-remitting multiple sclerosis (RRMS) in comparison teriflunomide (TRF). The study use drug DIV was carried out 48 weeks therapy.The multicenter, randomized, double-blind double-masked phase III clinical trial (CT) BCD-132-4/MIRANTIBUS included 338 adult RRMS distributed 1:1 ratio into two groups: TRF 14 mg. After...
Analysis of the dynamics epidemiological indicators multiple sclerosis (MS) in Altai region Russian Federation for period from 2009 to 2017.A comparative analysis prevalence, incidence and main clinical characteristics MS was carried out based on data patients with (1001 patients) 2017 (1322 patients).The prevalence increased 41.2 56.3 per 100 000. The higher disease cities compared villages (by 1.8 times) ratio women men about 2 0 have not changed. About 2% a family history MS. average age...
The first Forum of theBRICSNetworkUniversitywas held at the initiative Russian Ministry Education theUralFederalUniversityinYekaterinburg,Russiaon 6-9 April, 2016. included representatives Ministries and Science 44 universities fromRussia,India,China,BrazilandSouth Africato form an effective collaboration within framework most ambitious BRICS project in sphere education research -BRICSNetworkUniversity. aims to create a unified educational environment, enhancement academic mobility training...
Multiple sclerosis (MS) is a chronic autoimmune inflammatory demyelinating and neurodegenerative disease of the central nervous system. Now 2.8 million people in world suffer from MS, since 2000 every 5 years there has been an increase number MS patients by 10%. At same time, cases with highly active (HAMS) increasing, i.e. two or more exacerbations without taking specific pathogenetic therapy one exacerbation during disease-modifying therapies (DMTsMS), which accompanied corresponding MRI...
To study the efficacy and safety of siponimod in patients with secondary progressive multiple sclerosis (SPMS) Russian population EXPAND study.
Multiple sclerosis (MS) is often accompanied by a deficiency of vitamin D, the causes which are not exactly clear how. It suggested that this may be due to genetically determined characteristics enzymes D3 metabolism in patients with MS.To evaluate relationship between D status and polymorphisms genes encoding CYP27B1 (rs703842) CYP24A1 (rs2248359) MS.Caucasians born living Altai region Russian Federation, 90 relapsing-remitting MS 87 volunteers without took part study. The level...
During the outbreak of coronavirus disease 2019 (COVID-19) clinicians are increasingly involved in observation possible neurological complications due to infection severe acute respiratory syndrome 2 (SARS-CoV-2). Some cases encephalitis following COVID‐19 pandemic have been reported literature that can mean damage central nervous system related SARS-CoV-2 infection. Early on, this was thought be direct effects virus itself, but possibility immune mechanisms being implicated gradually raised...
To evaluate the relationship between level of glial fibrillary acidic protein (GFAP) in blood and rate progression (RP) neurological disorders exacerbation frequency multiple sclerosis (MS) presence/absence traumatic brain injury (TBI) before onset MS.
To analyze the epidemiological and clinical characteristics of myasthenia gravis (MG) in Altai region (AR).
To determine the relationship between level of soluble CD40 and CD40L (sCD40, sCD40L) key characteristics course multiple sclerosis.A comparative cross-sectional study covered 80 patients with sclerosis diagnosed according to 2005 McDonald criteria. Enzyme immunoassay method was applied measure concentration sCD40 sCD40L in venous blood serum.No significant changes sCDL or sСD levels were found during acute MS periods comparison remission periods. The positive correlation frequency...
To evaluate the association of traumatic brain injury (TBI) before multiple sclerosis (MS) onset with rate progression neurological disorders and cerebrospinal fluid markers blood-brain barrier permeability, inflammation, demyelination, gliosis.Patients relapsing-remitting MS in Altai region Russia with/without TBI (n=44; 19 men, 25 women each group) participated a prospective, controlled, randomized study. Disability was assessed retrospectively. Pleocytosis, levels protein, albumin,...
There are psychologic status of patients having multipled sclerosis research results. 30 were involved in the research, among them there 18 (60%) female and 12 (40%) male ones at age between 20 60. Patient examination was realized by means Spielberger, Maudsley Zung methods. As a result patient's psychological state changes. 66% have these changes form high-grade uneasiness, 50% — rigidity introversion, 83% depressing disorders slight depression subdepression. These findings expand our...
Recent systematic reviews and a meta-analysis have shown that there is insufficient evidence on the relationship of multiple sclerosis (MS) to vitamin D supplementation Objective : assess status in MS patients insolation, disease course, HLA-DRB1 gene polymorphism. Patients methods. The one-stage study enrolled 90 with relapsing-remitting (a group) 87 volunteers without this control group). were born live Altai Territory Russian Federation. serum level 25(OH)D was measured by enzyme...
Fahr disease is a rare hereditary or sporadic neurological condition characterized by bilateral calcium deposition in the basal ganglia, dentate nuclei of cerebellum, and subcortical white matter. We can also distinguish Farh syndrome when its etiology associated with disorder metabolism, mitochondriopathies, cerebrum neoplasms, infections, inflammatory diseases nervous system, injuries. The most common manifestations patients calcification ganglia are and/or psychiatric disorders varying...