A5002110247- Liver physiology and pathology
- Multiple Sclerosis Research Studies
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Diabetes and associated disorders
- Parkinson's Disease Mechanisms and Treatments
- Diabetes Management and Research
- Healthcare Systems and Public Health
- Human Health and Disease
- Neurogenesis and neuroplasticity mechanisms
- HIV Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Gut microbiota and health
- Pancreatitis Pathology and Treatment
- Restless Legs Syndrome Research
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Nerve injury and regeneration
- Systemic Sclerosis and Related Diseases
- HIV-related health complications and treatments
- Neurological disorders and treatments
- Alcohol Consumption and Health Effects
- Amyotrophic Lateral Sclerosis Research
- Metabolism, Diabetes, and Cancer
Siberian State Medical University
2012-2024
Ministry of Health of the Russian Federation
2011-2023
Kazan Federal University
2013-2022
North-Western State Medical University named after I.I. Mechnikov
2018-2021
Consultative and Diagnostic Center
2021
Research Institute of Human Morphology
2015
Kazan State Medical University
2006-2013
Federal Agency for Health and Social Development
2013
University Gastroenterology
2009
Multiple sclerosis (MS) is a serious, incurable neurological disease. In 2009, the ANZgene studies detected suggestive association of located upstream CD40 gene in chromosome 20q13 (p = 1.3×10−7). Identification causal variant(s) locus leads to better understanding mechanism underlying development autoimmune pathologies. We determined genotypes rs6074022, rs1883832, rs1535045, and rs11086996 patients with MS (n 1684) control group 879). Two SNPs were significantly associated MS: rs6074022...
Currently the role of microbiota in diseases pathogenesis, its therapeutic and diagnostic potential are utmost interest for scientists medical doctors. Parkinson’s disease is neurodegenerative disorder which microbiota’s dysbiosis was previously shown. The main goal study to compare colon composition case other neurological pathologies, including idiopathic familial dystonia, essential tremor, multiple sclerosis, system atrophy order determine intestinal flora landscape specific disease....
Approximately 5-10% of all cancers are associated with hereditary cancer predisposition syndromes (HCPS). Early identification HCPS is facilitated by widespread use next-generation sequencing (NGS) and brings significant benefits to both the patient their relatives. This study aims evaluate landscape genetic variants in patients personal and/or family history using NGS-based multigene panel testing.The cohort included 1117 probands from Russia: 1060 (94.9%) clinical signs 57 (5.1%) healthy...
Multiple sclerosis (MS) has a multifactorial etiology. To explore role of genetic factors in the pathogenesis MS, authors studied familial cases MS.For an analysis cases, database 320 MS patients registered Tomsk region since 1980 till 2014 was used. The following items for each patient were recorded: disease onset, manifestation disease, duration first remission, rate progression disease.Nine families with several members identified. In 2014, frequency population 4.7%. prevalence 1.4 per...
The purpose of this paper is to study the most common non-motor symptoms Parkinson’s disease (PD): olfactory dysfunction, constipation and associated with them variety fecal microorganisms in patients disease. Materials methods. We studied function 51 PD using Sniffin Sticks Test taxonomic composition microbiota. Results. Olfactory dysfunctions (hyposmia, anosmia) were found that participated as well differences alpha-variety gut microbiota among groups different characteristics. Conclusion....
Despite the efforts of scientific community data available on correlation between emotional-affective symptoms Parkinson’s disease and changes in microbiome is still scarce. Deeper studies nonmotor evident premotor stages reciprocal influence microbiota may help to understand etiology pathogenesis PD neurodegeneration better.Discover relations disorders prevalent population gut composition.51 patient diagnosed with participated study. Every participant’s state was examined using Beck’s...
Parkinson’s disease (PD) is a neurodegenerative disorder with complex pathogenesis. Today more and studies are focusing on microbiota-gut-brain axis searching the causes of neuroinflammatory processes. The aim our study to determine relationship between composition gut microbiota clinical manifestations PD. Materials methods. We examined 89 patients PD diagnosis. Clinical assessment was performed including medical history collection, rating stage using Hoehn Yahr scale. Motor nonmotor...
The Tomsk Region is a zone of average risk multiple sclerosis (MS), prevalence makes 27.1 cases on 100 000 people. During the period with 1980 for 2010 variety morbidity from 0.4 (1992) to 4.1 (2003) lowest was in 1991 1995 and 1.8 people, highest rage 2001 2005 — 3.1 Last 5 years TomskRegion increase ofmorbidityis observed.
Microbiota is a community of microorganisms, viruses, protozoa, colonizing the gut. There are tight phylogenetic relationships between gut microbiota and human body, disturbance which may lead to CNS dysfunction as well development neurodegenerative diseases. This review focuses on general specific aspects influence pathogenesis Parkinson's disease (PD). Current theories models relationship brain structures in PD presented with focus neurochemical immunological problem.Микробиота -...
The review presents data on brain-derived neurotrophic factor (BDNF), its structure and functions, the effect pathogenesis of experimental autoimmune encephalomyelitis multiple sclerosis (MS). correlation BDNF level with clinical manifestations MS changes during disease-modifying therapy is considered.В обзоре дано представление о мозговом нейротрофическом факторе его структуре и функциях, влиянии на патогенез экспериментального аутоиммунного энцефаломиелита рассеянного склероза (РС)....
One of the latest achievements in field medicine is introduction into practice technologies using computerized training and Virtual Reality (VR), which create new opportunities for prevention, as well treatment people suff ering from various cognitive impairments. Purpose study . The aim to investigate classical (conventional), VR neural interfaces focused on prevention rehabilitation functional changes higher nervous activity. Methods In March 2022, a search was made scientifi c full-text...
To study a role of serum neurofilament light chains (sNFL) in assessment course and progression multiple sclerosis (MS) the population patients with MS Tomsk region.
Two hundred and eighty patients (102 men 178 women; mean age 38.8ё0.7 years) with multiple sclerosis (MS) were examined to study its clinical picture in the Tomsk Region. There was a preponderance of have remitting MS whereas primarily progressive rarest. The bulk had moderate neurologic deficit disease progression. women observed exhibit more favorable course MS, which manifested itself as less severe neurological slower
To study the effect of RS6265 polymorphism BDNF gene on risk development, main clinical characteristics and DMT response in MS patients Tomsk region.The group included 321 patients, control consisted 266 healthy volunteers. Deoxyribonucleic acid (DNA) was isolated from venous blood using standard phenol-chloroform method. Genotyping carried out by real-time polymerase chain reaction (PCR) competing TaqMan probes complementary to polymorphic nucleotide sequence.Carriage C allele CC genotype...
The article overviews the distribution of Neolithic pottery Standard Hassuna period in Upper Mesopotamia: from foothills Taurus north to approximately region Diyala river south; Zagros east Balikh river, or possibly as far Euphrates west. In addition, (or influence this tradition) is recorded hinterland Zagros. Based on materials Yarim Tepe I settlement collection Pushkin State Museum Fine Arts, paper examines technological features pottery. They demonstrate a connection with technology...
Background . Nowadays many efforts are taken in searching for Parkinson’s disease biomarkers, especially an early recognition of the disease. The gut microbiota is one potential sources changes composition which PD actively studied. aim this study to identify biomarkers with estimated accuracy diagnostics, including differential relative other neurological diseases patients Russian population. Material and methods One hundred ninety-two metagenomics profiles from (n = 93), people diagnoses...
The study involved 280 patients aged 10 to 70 years old with a valid diagnosis of multiple sclerosis according the McDonald criteria. There are 6 (2.1%) had first manifestation disease overthe age 45, 18 (6.4%) – 20 earlier. In 7 (2.5%) diagnosed malignant progressof MS, in 30 (10.7%) soft progress.