A5052080152- Nerve injury and regeneration
- Stroke Rehabilitation and Recovery
- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Neurological Disorders and Treatments
- Multiple Sclerosis Research Studies
- Autoimmune Neurological Disorders and Treatments
- Amyotrophic Lateral Sclerosis Research
- Angiogenesis and VEGF in Cancer
- Skin and Cellular Biology Research
- Acute Ischemic Stroke Management
- S100 Proteins and Annexins
- Transcranial Magnetic Stimulation Studies
- Axon Guidance and Neuronal Signaling
- Glycogen Storage Diseases and Myoclonus
- Traumatic Brain Injury and Neurovascular Disturbances
- Restless Legs Syndrome Research
- Alzheimer's disease research and treatments
- Brain Metastases and Treatment
- Myasthenia Gravis and Thymoma
- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease and Spinal Disorders
- Lysosomal Storage Disorders Research
Siberian State Medical University
2015-2024
Ministry of Health of the Russian Federation
2021-2024
Institute of World Economy and International Relations
2020
To evaluate the clinical features and level of serum brain-derived neurotrophic factor (BDNF) in groups patients with Parkinson's disease (PD) differentiated by genotypes
Background: brain-derived neurotrophic factor (BDNF) may play a role during neurorehabilitation following ischemic stroke. This study aimed to elucidate the possible of BDNF early recovery from stroke assisted by motor training. Methods: fifty patients were included after acute stroke: 21 first received classical rehabilitation followed ‘motor using motion sensors and augmented reality’ (AR-rehabilitation), 14 only AR-rehabilitation, 15 observed. Serum levels measured on day stroke, 14th...
To evaluate the clinical and laboratory correlation of biomarkers with anti- pro-apoptotic activity severity motor non-motor symptoms depending on progression rate Parkinson's disease (PD).
Background: Motor recovery after stroke is based on neuronal plasticity and the structural reorganization of brain. Questions are debated about proper moment to start rehabilitation in acute period stroke, significance interventions during so-called “plastic window”, advantages modern traditional programs. The aims this study were evaluate role different strategies their combinations for motor impact functional disability by way neurological outcomes 3 months ischemic stroke. Methods: We...
Despite the high efficiency of use 18F-FDG PET in diagnosis, staging, monitoring and prognosis treatment lymphomas, this method our country is limited due to cost insufficient number PET-centers. In regard, it seems relevant conduct research aimed at using known developing original radiopharmaceuticals for lymphoma imaging with single-photon emission computed tomography (SPECT). review, main (67Ga-citrate, 201Tl, 199Tl, 99mTc-methoxy-isobutyl-isonitrile, 99mTc-tetrofosmin, 111In-octreotide),...
This literature review is devoted to the study of recent advances in field neurorehabilitation using robotic technologies. Objective: best practices applying rehabilitation technologies stroke patients, its clinical efficacy and influence on molecular mechanisms neuroplasticity. Keywords were searched Web Science, Core Collection, Scopus PubMed databases. Results. Robotic occupies a certain place comprehensive patients with motor deficiency after stroke. An interdisciplinary patient-oriented...
The issue of the diagnostic significance and clinical value neuron-specific enolase (NSE) brain-derived neurotropic factor (BDNF) in acute period stroke remains controversial. Therefore, it is advisable to study correlation biomarkers with characteristics time early recovery.To monitor NSE BDNF levels peripheral blood, analyze laboratory correlations patients ischemic at stages medical rehabilitation recovery period.Forty-nine middle cerebral artery were examined. observation 90 days....
Paraneoplastic cerebellar degeneration is the damage to Purkinje cells by anti-Yo antibodies synthesized immune system in response generation of neuronal proteins malignant prostate adenocarcinoma 25% cases. Neurological symptoms lesions appear on average 2 years before cancer manifestation 70% patients. During early stages disease, when tumor cannot be visualized nor clinically manifested, a high titer cerebrospinal fluid The presence with latent course was present 90–98% patients ataxia....
To study a role of serum neurofilament light chains (sNFL) in assessment course and progression multiple sclerosis (MS) the population patients with MS Tomsk region.
The review summarizes and analyzes the results of major foreign studies on role adipokine imbalance in development a severe course complications novel coronavirus infection (COVID-19). Adipokines are biologically active compounds produced by adipose tissue cells involved regulation metabolism functioning immune system. Obesity is proven risk factor for COVID-19 due to high hormonal metabolic activity visceral tissue. A deep understanding pathogenesis from point view it can provide grounds...
Modern understanding of the mechanisms pathogenesis ischemic stroke has expanded due to study neuroinfl ammation processes, in which matrix metalloproteinases (MMPs) play an important role. This literature review describes main types MMPs and provides current data on pathophysiological role this group proteases acute cerebral ischemia, have multidirectional eff ects depending stage disease. Clinical studies assessing are most cases based experimental models, their results ambiguous, is...
Background: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that affects people working age and ultimately leads to disability. This polygenic origin. The role factors related pathogenesis affecting both neuroinflammation remyelination studied. Aims: Our goal was investigate association single nucleotide polymorphisms BDNF rs6265 SLC1A2 rs4354668 with risk occurrence, clinical manifestations course MS.Materials methods: study included 302 patients MS, 268...
Neuronal ceroid lipofuscinoses (NCL, Batten disease) are a group of inherited neurodegenerative diseases characterized by age-related onset, progressive myoclonus epilepsy, visual impairment and intellectual motor disorders. In all forms NCL, the pathological autofluorescent lipopigment accumulates in brain other tissues. The diagnosis is made following determination activity specific enzymes blood leukocytes or cell culture skin fibroblasts investigation biopsy specimens with electron...
Introduction.The quality of rehabilitation measures used during early functional recovery can be assessed by registering somatosensory evoked potentials (SSEP). In many patients, SSEP are either not recorded, or the results poorly reproducible. To overcome these difficulties, we proposed to modify method recording in patients post ischaemic stroke. Theaimof study was evaluate changes after with stroke underwent motor period. Materials and methods.We examined 36 acute middle cerebral artery...
Cowden syndrome is a rare genetic disorder caused by the abnormal development of all three germ layers. Taking into consideration mesodermal origin mesenchymal tissue that gives rise to vascular system, pathology cerebral blood vessels can occur in conjunction with this disease and cause cerebrovascular such patients.
Multiple sclerosis (MS) is a chronic autoimmune disease with high degree of heterogeneity due to course and prognosis. More than half MS patients do not discuss their long-term prognosis the doctor. At same time, most consider importance personalized for decisions in family planning, career, medical interventions. Clinical markers are used determine routine clinical practice. However, it nominally divided into positive negative factors. It allows making general conclusion about Neuroimaging...
Objective . Development of a specialized software complex that creates controlled virtual environment as well to capture and calculate the movement data in process rehabilitation. Materials methods To evaluate impact visual stimuli created using augmented reality system on motor function, was developed visualizes via glasses processes obtained from motion sensors. The study conducted at Department Neurology Neurosurgery Medical Biological Cybernetics Siberian State University 2018–2019....
Kinsbourne’s syndrome or opsoklonus-myoclonus is an autoimmune disease of the central nervous system mainly affecting cerebellum and its connections. The characterized by progressive course rarely observed. There no accurate data on prevalence opsoklonusmyoclonus in Russia. etiology pathogenesis are being studied. This can develop against background cancer, infectious diseases vaccinations. article presents a ñlinical case this rare pathology.
Background. Using external robotic tools in rehabilitation of patients after stroke could activate neuroplasticity mechanisms, thus reducing the ischemic area and improving neurological outcome disease. Aim . To evaluate effectiveness early Tomsk Regional Stroke Center using assistive by correlational analysis clinical laboratory biomarkers brain neuroplasticity. Materials methods The study included 68 who suffered from middle cerebral artery. Early was carried out according to protocol....