A5011110340- Multiple Sclerosis Research Studies
- RNA and protein synthesis mechanisms
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Genetic Associations and Epidemiology
- T-cell and B-cell Immunology
- Biomarkers in Disease Mechanisms
- Systemic Lupus Erythematosus Research
- Cardiomyopathy and Myosin Studies
- Monoclonal and Polyclonal Antibodies Research
- Biochemical and Molecular Research
- Viral Infections and Immunology Research
- Epigenetics and DNA Methylation
- RNA regulation and disease
- Human Health and Disease
- Atherosclerosis and Cardiovascular Diseases
- Pediatric health and respiratory diseases
- ATP Synthase and ATPases Research
- Cardiovascular Syncope and Autonomic Disorders
- Mass Spectrometry Techniques and Applications
Pirogov Russian National Research Medical University
2016-2025
Ministry of Health of the Russian Federation
2014-2025
National Medical Research Center of Cardiology
2003-2025
Immanuel Kant Baltic Federal University
2023-2025
Institute of Experimental Cardiology
2007-2020
Russian Academy of Sciences
1974-2016
PharmacoGenetics (China)
2015
Federal Agency for Health and Social Development
2008
Hospital of the University of Pennsylvania
2003
Fox Chase Cancer Center
2003
Polygenic diseases are caused by the joint contribution of a number independently acting or interacting polymorphic genes; individual each gene may be small even unnoticeable. The carriage certain combinations genes can determine occurrence clinically heterogeneous forms disease and treatment efficacy. This review describes approaches used in polygenic analysis data medical genomics, particular, pharmacogenomics, aimed at identifying cumulative effect genes. result from summation gains...
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level through base-pairing predominantly with a 3-untranslated region of target mRNA, followed by mRNA degradation or translational repression. Totally, miRNAs change, complex regulatory network, more than 60% human genes. MiRNAs key regulators immune response affect maturation, proliferation, differentiation, and activation cells, as well antibody secretion release inflammatory...
Changes in cytokine profiles and networks are known to be a hallmark of autoimmune diseases, including systemic lupus erythematosus (SLE) multiple sclerosis (MS). However, research studies usually based on the analysis small number cytokines give conflicting results. In this work, we analyzed 41 analytes patients with SLE MS compared healthy donors using multiplex immunoassay. The group included treated patients, while were drug-free. Levels 11 cytokines, IL-1b, IL-1RA, IL-6, IL-9, IL-10,...
Abstract Various catalytic antibodies or abzymes have been detected recently in the sera of patients with several autoimmune pathologies, where their presence is most probably associated autoimmunization. Recently we shown that DNase, RNase, and polysaccharide‐hydrolyzing activities are IgGs from multiple sclerosis (MS). Here present evidence demonstrating highly purified MS (but not Igs healthy individuals) catalyze specifically hydrolysis human myelin basic protein (hMBP). In contrast to...
Caffeine is an efficient inhibitor of cellular DNA repair, likely through its effects on ATM (ataxia telangiectasia mutated) and ATR (ATM Rad3-related) kinases. Here, we show that caffeine treatment causes a dose-dependent reduction in the total amount HIV-1 avian sarcoma virus retroviral vector joined to host population infected cells also number transduced cells. These changes were observed at concentrations had little or no effect overall cell growth, synthesis, nuclear import viral DNA,...
In recent years, the number of studies focusing on genetic basis common disorders with a complex mode inheritance, in which multiple genes small effect are involved, has been steadily increasing. An improved methodology to identify cumulative contribution several polymorphous would accelerate our understanding their importance disease susceptibility and ability develop new treatments. A critical bottleneck is inability standard statistical approaches, developed for relatively modest...
Transfer RNA molecules have been labeled with 32P at the 5' or 3' end and digested cobra venom ribonuclease, which preferentially cuts double-stranded regions. The products of yeast tRNAPhe tRNAVal were analyzed by high-resolution gel electrohporesis. In free state, these tRNAs cut predominantly in acceptor anticodon stems. Minor occurred T psi stem tRNAVal. topography zones interacting their cognate synthetases was studied determining tRNA regions shielded protein. Nearly 100% protection...
The epigenetic mechanisms of gene expression regulation are a group the key cellular and molecular pathways that lead to inherited alterations in genes' activity without changing their coding sequence. DNA methylation at C5 position cytosine CpG dinucleotides is amongst central mechanisms. Currently, number studies devoted identification patterns specific multiple sclerosis (MS), severe chronic autoimmune disease nervous system, on rapid rise. However, issue contribution development...
Opisana rol' mikroRNK (malyh nekodiruyushchih RNK) v regulyacii ekspressii genov. Svyazyvayas' s mRNK-mishenyami, kontroliruyut ekspressiyu kodiruyushchih eti mRNK genov na posttranskripcionnom urovne, uchastvuya fiziologicheskih i patologicheskih processah ot embriogeneza do opuholevyh zabolevanij. S momenta otkrytiya etih molekul 1993 g. razlichnye nauchnye gruppy issleduyut funkcii mekhanizmy dejstviya mikroRNK. V stat'e rassmotreny puti biogeneza mikroRNK, sposoby vzaimodejstviya...
The role of miRNAs (small non-coding RNAs) in regulation gene expression is reported. By binding with target mRNAs control the genes encoding these at post-transcriptional level taking part physiological and pathological processes, from embryogenesis to neoplastic disorders. Various research teams have been studying miRNA functions mechanisms action since discovery molecules 1993. paper reports biogenesis pathways, modes interaction between mRNAs, underlying suppression translation mRNA...
Studies of cytokines in multiple sclerosis (MS) have shown that immune mechanisms connected with disturbance the synthesis probably play critical roles initiation and prolongation MS. In a double-blind, placebo-controlled trial, 45 patients active secondary progressive MS were randomized to three groups 15 patients, each receiving short course antibodies IFN-g, tumor necrosis factor (TNF)-a, or placebo. After 12 months analysis disability (Expanded Disability Status Scale scores),...
Multiple sclerosis (MS) is a severe neurodegenerative disease of polygenic etiology affecting the central nervous system. In addition to genetic factors, epigenetic mechanisms, primarily DNA methylation, which regulate gene expression, play an important role in MS development and progression. this study, we have performed first whole-genome methylation profiling peripheral blood mononuclear cells relapsing-remitting (RRMS) primary-progressive (PPMS) patients compared them those healthy...
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system polygenic nature, characterized by focal inflammation, demyelination and neurodegeneration. The clinical course MS great heterogeneity. consistency forms in families indicates involvement genomic variation development phenotype. Identifying genetic basis progression may not only explain nature observed heterogeneity but also contribute to new tools for appropriate prognosis personalized treatment disease....