A5039304360- Multiple Sclerosis Research Studies
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Biomarkers in Disease Mechanisms
- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- interferon and immune responses
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- Pediatric health and respiratory diseases
- Art, Politics, and Modernism
- Diverse Scientific Research in Ukraine
- Immune responses and vaccinations
- European Linguistics and Anthropology
- Epigenetics and DNA Methylation
- Natural product bioactivities and synthesis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Art, Technology, and Culture
- Labor Market and Education
- COVID-19 Clinical Research Studies
- Genomic variations and chromosomal abnormalities
- Medical and Biological Sciences
- Hemoglobin structure and function
- RNA regulation and disease
Lomonosov Moscow State University
2022
Pirogov Russian National Research Medical University
2011-2019
Ministry of Health of the Russian Federation
2015-2019
Institute of Experimental Cardiology
2010-2016
PharmacoGenetics (China)
2015
Multiple sclerosis (MS) is a severe neurodegenerative disease of polygenic etiology affecting the central nervous system. In addition to genetic factors, epigenetic mechanisms, primarily DNA methylation, which regulate gene expression, play an important role in MS development and progression. this study, we have performed first whole-genome methylation profiling peripheral blood mononuclear cells relapsing-remitting (RRMS) primary-progressive (PPMS) patients compared them those healthy...
<h3>Objective</h3> A recent large-scale study in multiple sclerosis (MS) using the ImmunoChip platform reported on 11 loci that showed suggestive genetic association with MS. Additional data sufficiently sized and independent sets are needed to assess whether these represent genuine MS risk factors. <h3>Methods</h3> The lead SNPs of all were genotyped 10 796 cases 793 controls from Germany, Spain, France, Netherlands, Austria Russia, previously cohorts. Association analyses performed...
Multiple sclerosis (MS) is a serious, incurable neurological disease. In 2009, the ANZgene studies detected suggestive association of located upstream CD40 gene in chromosome 20q13 (p = 1.3×10−7). Identification causal variant(s) locus leads to better understanding mechanism underlying development autoimmune pathologies. We determined genotypes rs6074022, rs1883832, rs1535045, and rs11086996 patients with MS (n 1684) control group 879). Two SNPs were significantly associated MS: rs6074022...
In spite of progress in cardiovascular genetics, data on genetic background myocardial infarction are still limited and contradictory. This applies as well to the genes involved inflammation coagulation processes, which play a crucial role disease etiopathogenesis. this study we found variants TGFB1, FGB CRP associated with discovery replication groups Russian descent from Moscow region Republic Bashkortostan (325/185 220/197 samples, correspondingly). We also replicated biallelic...
Background: Glatiramer acetate (GA) is widely used as a first-line disease-modifying treatment for multiple sclerosis (MS). However, significant proportion of MS patient appears to experience modest benefit from GA-treatment. Genetic variants affecting the clinical response GA are believed be relevant biomarkers GA-treatment efficiency. Patients & methods: Nine polymorphisms in candidate genes were analyzed possible determinants 285 Russian patients. Special attention was given...
Various diseases require the selection of preferable treatment out available alternatives. Multiple sclerosis (MS), an autoimmune inflammatory/neurodegenerative disease CNS, requires long-term medication with either specific disease-modifying therapy (DMT) – IFN-β or glatiramer acetate (GA) which remain only first-line DMTs in all countries. A significant share MS patients are resistant to one other DMT; therefore, earliest choice DMT is particular importance. number conventional...
Background: IFN-β is widely used as the first-line disease-modifying treatment for multiple sclerosis. However, 30–50% of sclerosis patients do not respond to this therapy. Identification genetic variants and their combinations that predict responsiveness could be useful prognosis. Materials & methods: The alleles nine polymorphic loci in immune-response genes were analyzed 253 Russian possible determinants clinically optimal response using APSampler software. Results: Carriage TGFB1*-509C...
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS). Proteins immune system, as well proteins that are involved in infiltration activated cells CNS, play an important role pathogenesis MS. We investigated association and linkage with MS following immune-system genes polymorphisms: HLA-DRB1,CTLA4,TGFB1,IL4,CCR5 andRANTES, matrix metalloproteinase 9 (MMP9) tissue inhibitor 1 (TIMP1) polymorphisms. For this purpose we used transmission...
Aim: Association analysis of genome-wide association studies (GWAS) identified multiple sclerosis (MS) risk genetic variants with glatiramer acetate (GA) treatment efficacy. Patients & methods: SNPs in 17 GWAS-identified immune response loci were analyzed 296 Russian MS patients as possible markers optimal GA for at least 2 years. Results: Alleles/genotypes EOMES, CLEC16A, IL22RA2, PVT1 and HLA-DRB1 associated by themselves event-free phenotype during years (p f = 0.032 - 0.00092). The...
To study the association of polymorphisms in IL2RA and TNFRSF1A genes with severity early clinical manifestations remitted multiple sclerosis (MS).Five hundred eight patients Russian ethnicity bout-onset MS were genotyped for IL7RA (rs6897932), (rs2104286) (rs1800693) polymorphisms. Association analysis gene variants disease severity, manifestation, first remission duration was performed.Dividing by estimated MSSS, we found a significant increase TNFRSF1A*T/T genotype carriage milder course...