A5002808599- Multiple Sclerosis Research Studies
- Cytokine Signaling Pathways and Interactions
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- RNA regulation and disease
- Epigenetics and DNA Methylation
- Immune responses and vaccinations
- Viral Infections and Immunology Research
- Immune Response and Inflammation
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Circular RNAs in diseases
- Biomarkers in Disease Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pediatric health and respiratory diseases
- interferon and immune responses
- Genetic Associations and Epidemiology
- Mitochondrial Function and Pathology
- Reproductive System and Pregnancy
- Yersinia bacterium, plague, ectoparasites research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Cell Function and Interaction
Pirogov Russian National Research Medical University
2016-2025
Ministry of Health of the Russian Federation
2003-2025
National Medical Research Center of Cardiology
2017-2025
Immanuel Kant Baltic Federal University
2023-2025
Institute of Experimental Cardiology
2010-2020
Agia Olga Hospital
2019
PharmacoGenetics (China)
2015
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level through base-pairing predominantly with a 3-untranslated region of target mRNA, followed by mRNA degradation or translational repression. Totally, miRNAs change, complex regulatory network, more than 60% human genes. MiRNAs key regulators immune response affect maturation, proliferation, differentiation, and activation cells, as well antibody secretion release inflammatory...
The epigenetic mechanisms of gene expression regulation are a group the key cellular and molecular pathways that lead to inherited alterations in genes' activity without changing their coding sequence. DNA methylation at C5 position cytosine CpG dinucleotides is amongst central mechanisms. Currently, number studies devoted identification patterns specific multiple sclerosis (MS), severe chronic autoimmune disease nervous system, on rapid rise. However, issue contribution development...
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system polygenic nature, characterized by focal inflammation, demyelination and neurodegeneration. The clinical course MS great heterogeneity. consistency forms in families indicates involvement genomic variation development phenotype. Identifying genetic basis progression may not only explain nature observed heterogeneity but also contribute to new tools for appropriate prognosis personalized treatment disease....
Studies of cytokines in multiple sclerosis (MS) have shown that immune mechanisms connected with disturbance the synthesis probably play critical roles initiation and prolongation MS. In a double-blind, placebo-controlled trial, 45 patients active secondary progressive MS were randomized to three groups 15 patients, each receiving short course antibodies IFN-g, tumor necrosis factor (TNF)-a, or placebo. After 12 months analysis disability (Expanded Disability Status Scale scores),...
Multiple sclerosis (MS) is a severe neurodegenerative disease of polygenic etiology affecting the central nervous system. In addition to genetic factors, epigenetic mechanisms, primarily DNA methylation, which regulate gene expression, play an important role in MS development and progression. this study, we have performed first whole-genome methylation profiling peripheral blood mononuclear cells relapsing-remitting (RRMS) primary-progressive (PPMS) patients compared them those healthy...
Multiple sclerosis (MS) is an autoimmune neuro-inflammatory disease arising from complex interactions of genetic, epigenetic, and environmental factors. Variations in genes some microRNAs--key post-transcriptional regulators many genes--can influence microRNAs expression/function contribute to MS via expression changes protein-coding target mRNA genes. We performed association study polymorphous variants MIR146A rs2910164, MIR196A2 rs11614913, MIR499A rs3746444 MIR223 rs1044165 their...
Risk of the development multiple sclerosis (MS) is known to be increased in individuals bearing distinct class II human leukocyte antigen (HLA) variants, whereas some them may have a protective effect. Here we analyzed distribution highly polymorphous HLA-DRB1 locus more than one thousand relapsing-remitting MS patients and healthy Russian ethnicity. Carriage HLA-DRB1*15 HLA-DRB1*03 alleles was associated with risk, carriage HLA-DRB1*01 HLA-DRB1*11 found protective. Analysis genotypes...
The aim of this study was to determine the role HLA-<i>DRB1</i> gene [6p21] in susceptibility juvenile MS (JMS) (age at onset ≤15 years) children Russian descent. Association DR2(15) with JMS has been found by comparison patients both unrelated and affected family-based healthy controls. linkage shown transmission disequilibrium test. There were no significant differences frequencies <i>DRB1</i> alleles genotypes between 56 234 age ≥16 years.
Multiple sclerosis (MS) is a serious, incurable neurological disease. In 2009, the ANZgene studies detected suggestive association of located upstream CD40 gene in chromosome 20q13 (p = 1.3×10−7). Identification causal variant(s) locus leads to better understanding mechanism underlying development autoimmune pathologies. We determined genotypes rs6074022, rs1883832, rs1535045, and rs11086996 patients with MS (n 1684) control group 879). Two SNPs were significantly associated MS: rs6074022...
In spite of progress in cardiovascular genetics, data on genetic background myocardial infarction are still limited and contradictory. This applies as well to the genes involved inflammation coagulation processes, which play a crucial role disease etiopathogenesis. this study we found variants TGFB1, FGB CRP associated with discovery replication groups Russian descent from Moscow region Republic Bashkortostan (325/185 220/197 samples, correspondingly). We also replicated biallelic...
Relapsing-remitting multiple sclerosis (RRMS) is the most prevalent course of sclerosis. It an autoimmune inflammatory disease central nervous system. To investigate gender-specific involvement microRNAs (miRNAs) in RRMS pathogenesis, we compared miRNA profiles peripheral blood mononuclear cells separately men and women (eight patients versus four healthy controls each gender) using high-throughput sequencing. In contrast to women, six downregulated 26 upregulated miRNAs (padj < 0.05)...
Background: Glatiramer acetate (GA) is widely used as a first-line disease-modifying treatment for multiple sclerosis (MS). However, significant proportion of MS patient appears to experience modest benefit from GA-treatment. Genetic variants affecting the clinical response GA are believed be relevant biomarkers GA-treatment efficiency. Patients & methods: Nine polymorphisms in candidate genes were analyzed possible determinants 285 Russian patients. Special attention was given...
Various diseases require the selection of preferable treatment out available alternatives. Multiple sclerosis (MS), an autoimmune inflammatory/neurodegenerative disease CNS, requires long-term medication with either specific disease-modifying therapy (DMT) – IFN-β or glatiramer acetate (GA) which remain only first-line DMTs in all countries. A significant share MS patients are resistant to one other DMT; therefore, earliest choice DMT is particular importance. number conventional...
The authors studied the possible association between presence of a 32-base pair deletion allele in CC chemokine receptor 5 gene [3p21] (CCR5 Delta 32 allele) and occurrence MS. CCR5 homozygotes among patients with MS indicates that absence did not protect against Moreover, mutation was associated HLA-DR4-positive Russians (p(corr) < 0.001, odds ratio [OR] = 25.0). 32,DR4)-positive phenotype negatively early onset (at ages or 18 years) (p 0.0115, OR 0.1).
Multiple sclerosis (MS) is an immune-mediated disease of polygenic etiology. Dissection its genetic background a complex problem, because the combinatorial possibilities gene-gene interactions. As genotyping methods improve throughput, approaches that can explore multigene interactions appropriately should lead to improved understanding MS. 286 unrelated patients with definite MS and 362 healthy controls Russian descent were genotyped at polymorphic loci (including SNPs, repeat...