A5009338095- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Circadian rhythm and melatonin
- Chemical and Physical Studies
- Humic Substances and Bio-Organic Studies
- Contact Dermatitis and Allergies
Ministry of Health
2023
Federal Medical-Biological Agency
2021-2023
Institute of Immunology and Physiology
2020-2023
Belarusian State Medical University
2023
Abstract Background The nature of epitopes on Bet v 1 recognized by natural IgG antibodies birch pollen allergic patients and pollen‐exposed but non‐sensitized subjects has not been studied in detail. Objective To investigate IgE recognition to study the effects 1‐specific 1‐induced basophil activation. Methods Sera from (BPA, n = 76), without allergy (NBPA, 40) non‐allergic individuals (NA, 48) were tested for IgE, as well 4 reactivity folded recombinant 1, two unfolded fragments comprising...
Risk of the development multiple sclerosis (MS) is known to be increased in individuals bearing distinct class II human leukocyte antigen (HLA) variants, whereas some them may have a protective effect. Here we analyzed distribution highly polymorphous HLA-DRB1 locus more than one thousand relapsing-remitting MS patients and healthy Russian ethnicity. Carriage HLA-DRB1*15 HLA-DRB1*03 alleles was associated with risk, carriage HLA-DRB1*01 HLA-DRB1*11 found protective. Analysis genotypes...
Роль ИЛ-25, ИЛ-33 и TSLP в развитии кортикостероидной резистентности 1 Федеральное государственное бюджетное учреждение «Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства, 115522 , г. Москва, Российская Федерация 2 Учреждение образования «Белорусский государственный медицинский университет» Министерства здравоохранения Республики Беларусь
IgE-mediated allergy to birch pollen affects more than 100 million patients world-wide. Bet v 1, a 17 kDa protein is the major allergen in responsible for allergic rhinoconjunctivitis and asthma patients. Allergen-specific immunotherapy (AIT) based on therapeutic administration of 1-containing vaccines an effective treatment but no allergen-specific forms prevention are available. We developed mouse model IgE sensitization 1 subcutaneous injection aluminum-hydroxide adsorbed recombinant...
Abstract Background IgE cross‐sensitization to major birch pollen allergen Bet v 1 and pathogenesis‐related (PR10) plant food allergens is responsible for the pollen‐food allergy syndrome. Methods We designed a recombinant protein, AB‐PreS, consisting of non‐allergenic peptides derived from IgE‐binding sites cross‐reactive apple allergen, Mal d 1, fused PreS domain HBV surface protein as immunological carrier. AB‐PreS was expressed in E. coli purified by chromatography. The allergenic...
Natural products (e.g., polyphenols) have been used as biologically active compounds for centuries. Still, the mechanisms of biological activity these multicomponent systems are poorly understood due to a lack appropriate experimental techniques. The method tritium thermal bombardment allows non-selective labeling and tracking all components complex natural systems. In this study, we applied it label two well-characterized polyphenolic compounds, peat fulvic acid (FA-Vi18) oxidized lignin...
Новые подходы к аллерген-специфической иммунотерапии (АСИТ): разработка рекомбинантной вакцины от аллергии на пыльцу березы 1 Федеральное государственное бюджетное учреждение «Государственный научный центр «Институт иммунологии» Федерального медико-
Background: Respiratory birch pollen allergy and associated oral syndrome affect more than 150 million people. IgE cross-sensitization to major allergen Bet v 1 pathogenesis-related (PR10) plant food allergens is responsible for the pollen-food syndrome. Methods: We designed a recombinant protein, AB-PreS, consisting of non-allergenic peptides derived from binding sites cross-reactive apple allergen, Mal d 1, fused PreS domain HBV surface protein as immunological carrier. AB-PreS was...
Продукция цитокинов наивными В-лимфоцитами и В-клетками памяти при стимуляции in vitro 1 Федеральное государственное бюдж етное учреждение «Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства, 115522, г.Москва, Российская Федерация 2 бюджетное образовательное высшего образования «Московский государственный университет им.М.В.Ломоносова», 119234, 3 автономное «Российский дружбы народов имени Патриса Лумумбы» Министерства науки Российской Федер...
Новые подходы к аллерген-специфической иммунотерапии (АСИТ): разработка рекомбинантной вакцины от аллергии на пыльцу березы 1 Федеральное государственное бюджетное учреждение «Государственный научный центр «Институт иммунологии» Федерального медико-