A5047620765- Immunodeficiency and Autoimmune Disorders
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood disorders and treatments
- Mast cells and histamine
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Drug-Induced Adverse Reactions
- Immune responses and vaccinations
- Pediatric health and respiratory diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Asthma and respiratory diseases
- Autoimmune Bullous Skin Diseases
- Platelet Disorders and Treatments
- Pharmacovigilance and Adverse Drug Reactions
- Blood groups and transfusion
- T-cell and B-cell Immunology
- Vaccine Coverage and Hesitancy
- Facial Trauma and Fracture Management
- Pharmaceutical studies and practices
- SARS-CoV-2 and COVID-19 Research
- Chronic Lymphocytic Leukemia Research
- Hepatitis C virus research
- RNA regulation and disease
Federal Medical-Biological Agency
2016-2024
Institute of Immunology
2012-2024
Moscow State University of Medicine and Dentistry
2014-2024
State Research Center of the Russian Federation
2020-2023
Institute of Immunology and Physiology
2017-2023
Immunodeficiency-associated vaccine-derived polioviruses (iVDPVs) have been isolated from primary immunodeficiency (PID) patients exposed to oral poliovirus vaccine (OPV). Patients may excrete strains for months or years; the excreted viruses are frequently highly divergent parental OPV and shown be as neurovirulent wild virus. Thus, these represent a potential reservoir transmission of in post-eradication era. In support WHO recommendations better estimate prevalence excreters among PIDs...
Nijmegen breakage syndrome (NBS) is a DNA repair disorder characterized by combined immunodeficiency and high predisposition to lymphoid malignancies. The majority of NBS patients are identified with homozygous five base pair deletion in the Nibrin ( NBN) gene (c.657_661del5, p.K219fsX19) founder effect observed Caucasian European populations, especially Slavic origin. We present here an analysis cohort 136 Eastern Slav origin across Belarus, Ukraine, Russia, Latvia focus on understanding...
Primary immunodeficiencies (PID) are a group of rare genetic disorders with multitude clinical symptoms. Characterization epidemiological and data via national registries has proven to be valuable tool studying these diseases. Materials Methods. The Russian PID registry was set up in 2017, by the National Association Experts (NAEPID). It is secure, internet-based database that includes detailed clinical, laboratory therapeutic on patients all ages. Results. contained information 2728 (60%...
Introduction The J Project (JP) physician education and clinical research collaboration program was started in 2004 includes by now 32 countries mostly Eastern Central Europe (ECE). Until the end of 2021, 344 inborn errors immunity (IEI)-focused meetings were organized JP to raise awareness facilitate diagnosis treatment patients with IEI. Results In this study, meeting profiles major diagnostic parameters studied. center leaders reported patients’ data from 30 representing a total...
Anaphylaxis is a severe life-threatening emergency that requires prompt recognition, respond and of lifesaving therapy. Therefore, anaphylaxis can develop both in medical institution outside it (outpatient), physicians any specialties should be ready to treat this condition. In regard, clinical guidelines for have been developed Russia. Previous version recommendations were approved by the Russian Association Allergologists Clinical Immunologists Federation Anesthesiologists Resuscitators,...
Background. The common wormwood pollen (lat. Artemisia absinthium) is one of the strongest allergens in central Russia, Europe and a number other regions. It perennial herbaceous plant Asteraceae family, which easily adapts to various conditions, displacing species. Allergen-specific therapy (ASIT) currently considered only effective method treating allergies, since it directly affects different phases disease, correcting body's response allergen. effectiveness this reaches 80-90% shows...
The increase in the frequency and unfavorable outcomes of anaphylactic shock recent decades determines need for development clear definitions, diagnosis treatment both prevention possible complications associated with it. article provides options course shock, algorithms treatment.
Cardioprotective effect of resveratrol and resveratroloside was determined in ischemia-reperfusion experiments on rats. It found that single intraperitoneal administration any compound (10 mg/kg) followed by 30-min ischemia 120-min reperfusion resulted statistically significant decrease myocardial infarct area (55.0±4.0% for control group; 40.7±4.4% the group 1 received resveratrol; 41.6±4.8% 2 resveratroloside). The cardioprotective detected first time.
As vaccine-induced immunity and protection following natural pertussis infection wane over time, adults adolescents may develop become transmitters to unprotected infants. In Russia, diphtheria tetanus but not pertussis-containing vaccines are registered for older children, adolescents, or adults. The reduced-antigen-content toxoid, acellular (dTpa) vaccine (Boostrix, GSK) was developed booster vaccination of children ≥4 years age, A phase III, open-label, non-randomized study performed in...
BACKGROUND: Hereditary angioedema with C1 inhibitor deficiency is a rare disease caused by and/or decrease in the functional activity of inhibitor. The primary symptom this condition recurrent various localizations. According to modern concept treatment, therapy aims stop emerging and prevent death as well achieve complete control high quality life. Lanadelumab medicine developed used attacks patients hereditary aged 12 years.
 AIM: A retrospective study (IISR-2021-200085) was conducted...
Результаты I и II фазы клинических исследований препарата МИР 19 ® 1 Федеральное государственное бюджетное учреждение «Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства, 115522, г.Москва, Российская Федерация 2 автономное образовательное высшего образования «Российский национальный исследовательский медицинский университет имени Н.И.Пирогова» Министерства здравоохранения Российской Федерации, 117997, 3 научное «Научно-исследовательский институт...
Over 40 years of use demonstrates that complement 1 esterase inhibitor (C1-INH) concentrate is effective and well tolerated for acute edema attacks prophylaxis in patients with hereditary angioedema. OCTA-C1-INH a new stable, virus-inactivated, nanofiltrated C1-INH derived from human plasma.We investigated the pharmacokinetics safety profile people angioedema during an attack-free period.In this prospective, multicenter, open-label, single-arm study, adults type I/II received single...
The emergence of highly effective therapy has led to an increase in the life expectancy patients with primary immunodeficiency (PID). Currently, we have opportunity observe first generation adults suffering from PID. Objective. To study structure PID forms Russian register Institute immunology FMBA Russia. Materials and methods. analysis structure, demographic data need for was carried out on basis of472 patient’s case histories who were treated 1983 2017. Results. main part older than 18...
Hereditary angioedema is a rare, potentially life-threatening genetic disease that manifests with skin and mucous/submucosal swelling occurs under the influence of bradykinin. The clinical guidelines for hereditary (code International Statistical Classification Diseases Related Health Problems D84.1) were developed in December 2020 by Russian Association Allergology Clinical Immunology, Medical Geneticists, National Experts Field Primary Immunodeficiencies, Union Pediatricians Russia. In...
Hereditary angioedema is a rare (orphan) disease associated with the development of various localization caused by action bradykinin. The main symptoms are peripheral angioedema, abdominal attacks (accompanied severe pain syndrome), edema upper respiratory tract, which may lead to asphyxia and death patient. Peripheral disrupts social professional activity, occurrence facial complicates adaptation, unpredictability potential threat life in larynx, as well lack effect from standard (systemic...
Primary immunodeficiencies (PIDs) are a group of congenital diseases the immune system, which numbers more than 230 nosological entities associated with lost, decreased, or wrong function its one several components. Due to common misconception that these extremely rare occur only in children and lead their death at an early age, PIDs frequently ruled out by physicians related specialties from range differential diagnosis. The most forms PIDs, such as humoral immunity defects, variable...
BACKGROUND: The main mechanism of drug hypersensitivity to non-steroidal anti-inflammatory drugs is associated with inhibition cyclooxygenase type 1, which leads cross-hypersensitivity reactions from various subgroups different chemical structures. Clinically, usually manifests in the form urticaria and/or angioedema. AIM: To characterize a group patients manifesting as / angioedema anaphylaxis. MATERIALS AND METHODS: achieve this aim prospective single-center study was conducted. Patients...
Клиническая иммунология
The main cause of death in the intensive care units is infectious complications, including sepsis and septic shock. Immunoglobulins are most potent mechanisms anti-infective defense. Whether intravenous immunoglobulins should be used urgent situations remains to solved. action diverse depend on dosage time use. paper analyzes data available Russian foreign literature possible points use treatment acute conditions accompanied by sepsis. It also gives authors’ treat toxic epidermal...
Продукция цитокинов наивными В-лимфоцитами и В-клетками памяти при стимуляции in vitro 1 Федеральное государственное бюдж етное учреждение «Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства, 115522, г.Москва, Российская Федерация 2 бюджетное образовательное высшего образования «Московский государственный университет им.М.В.Ломоносова», 119234, 3 автономное «Российский дружбы народов имени Патриса Лумумбы» Министерства науки Российской Федер...
Hereditary angioedema is a hereditary life-threatening disease characterized by recurrent of various strength and localization. To date, definite diseases severity criteria have not been developed. There are many different factors to consider only the frequency episodes, but also their duration, strength, influence on patient's appearance, pain syndrome. Disease related quality life, number work disability days, satisfaction with prescribed treatment important. In addition, there no for...