A5029117295- Immunodeficiency and Autoimmune Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Parvovirus B19 Infection Studies
- Blood disorders and treatments
- Urticaria and Related Conditions
- Protein Interaction Studies and Fluorescence Analysis
- Systemic Sclerosis and Related Diseases
- Botulinum Toxin and Related Neurological Disorders
- Mast cells and histamine
- Hereditary Neurological Disorders
- Autoimmune Bullous Skin Diseases
- Blood groups and transfusion
- Effects of Radiation Exposure
- Radiation Dose and Imaging
- Genetic Neurodegenerative Diseases
- Peptidase Inhibition and Analysis
- Electron Spin Resonance Studies
- Inflammatory Myopathies and Dermatomyositis
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Parkinson's Disease and Spinal Disorders
- SARS-CoV-2 and COVID-19 Research
- Peripheral Neuropathies and Disorders
- Air Quality and Health Impacts
Riga Stradiņš University
2014-2025
Pauls Stradiņš Clinical University Hospital
2014-2025
Children's Clinical University Hospital
2022-2025
Abstract Background Chronic spontaneous urticaria (CSU) is unpredictable and can severely impair patients' quality of life. Patients with CSU need a convenient, user‐friendly platform to complete patient‐reported outcome measures (PROMs) on their mobile devices. CRUSE ® , the Urticaria Self Evaluation app, aims address this unmet need. Methods was developed by an international steering committee specialists. Priorities for app based recent findings in were defined allow patients track record...
Abstract Background and purpose Charcot‐Marie‐Tooth (CMT) disease is a chronic, slowly progressing disorder. The lack of specific progression biomarkers limits the execution clinical trials. However, neurofilament light chain (NfL) has been suggested as potential biomarker for peripheral nervous system disorders. Methods Ninety‐six CMT patients 60 healthy controls were enrolled in study. Disease severity assessment included evaluation with Neuropathy Score version 2 (CMTNSv2). Blood plasma...
Background: Angioedema (AE) is a localized, non-pitting swelling affecting subcuta-neous and/or submucosal tissues. Despite varying underlying mechanisms, AE signif-icantly impacts patients' quality of life (QoL), which closely linked to disease activity and control. Objectives: This study aimed translate linguistically validate the angioedema score (AAS), control test (AECT), (AE-QoL) questionnaires into Latvian, use these validated tools assess activity, control, within...
Background: Angioedema (AE) is a localized, non-pitting swelling affecting subcutaneous and/or submucosal tissues. Despite varying underlying mechanisms, AE significantly impacts patients' quality of life (QoL), which closely linked to disease activity and control. Objectives: This study aimed translate linguistically validate the angioedema score (AAS), control test (AECT), (AE-QoL) questionnaires into Latvian, use these validated tools assess activity, control, within population. Methods:...
Inborn errors of immunity (IEI), a diverse group rare inborn disorders involving over 500 genes, pose diagnostic challenges despite next-generation sequencing advancements. Accurate molecular diagnosis is crucial for personalized treatment. This study aimed to assess the complementary role genome and transcriptome in improving yield immunity. A cohort 37 suspected IEI cases mainly consisting predominantly primarily antibody deficiency (PAD) (27/37) underwent sequencing. We validated analysis...
The outcome of the Chernobyl nuclear power plant (CNPP) accident was that a huge number people were exposed to ionizing radiation. Previous studies CNPP clean-up workers from Latvia revealed high occurrence age-associated degenerative diseases and cancer in young adults, as well mortality result cardiovascular disorders at age 45–54 years. DNA tandem repeats cap chromosome ends, known telomeres, are sensitive oxidative damage exposure Telomeres important aging processes carcinogenesis. aim...
Abstract Hereditary angioedema (HAE) poses diagnostic challenges due to its episodic, non-specific symptoms and overlapping conditions. This study focuses on the genetic basis of HAE, particularly focusing unresolved cases those with normal C1-inhibitor levels (nC1-INH HAE). reveals that conventional testing identified pathogenic variants in only 10 patients ( n = 32), emphasizing necessity for an integrative approach using genome, exome, transcriptome sequencing. Despite extensive analyses,...
Myasthenia gravis (MG) is an autoimmune disorder characterized by fatigable muscle weakness due to antibody-mediated impairment of neuromuscular transmission. The aim this study was investigate the incidence and prevalence MG in Latvia, characterize population well-established clinical parameters such as age at onset, presence associated antibodies thymus pathology.All prevalent cases on 1 January 2015 patients newly presenting with symptoms from 2010 31 December 2014 were selected database...
Some studies have found increased coronavirus disease-19 (COVID-19)-related morbidity and mortality in patients with primary antibody deficiencies. Immunization against COVID-19 may, therefore, be particularly important these patients. However, the durability of immune response remains unclear such In this study, we evaluated cellular humoral to severe acute respiratory syndrome 2 (SARS-CoV-2) antigens a cross-sectional study 32 deficiency (n = 17 common variable immunodeficiency (CVID) n 15...
Charcot-Marie-Tooth disease (CMT) is a hereditary, slowly progressive neuropathy. Currently, there are no effective pharmacological treatments or sensitive activity biomarkers available. The aim of this study was to demonstrate the change in plasma neurofilament light chain (NfL) over time CMT cohort and analyse association between severity NfL level.Initially, 101 patients 64 controls were enrolled study. Repeated evaluation performed 73 28 at 3-year interval. Disease assessment included...
Abstract Background Hereditary angioedema (HAE) is a rare and life-threatening inborn error of immunity. HAE mostly caused by pathogenic variations in the serine protease inhibitor gene 1 ( SERPING1 ), leading to deficient or dysfunctional C1-inhibitor (C1-INH), overproduction bradykinin, development recurrent subcutaneous and/or submucosal oedema. The prevalence 50,000 − 100000 people worldwide. We aimed describe clinical features genetic spectrum hereditary with C1-INH deficiency...
Introduction The J Project (JP) physician education and clinical research collaboration program was started in 2004 includes by now 32 countries mostly Eastern Central Europe (ECE). Until the end of 2021, 344 inborn errors immunity (IEI)-focused meetings were organized JP to raise awareness facilitate diagnosis treatment patients with IEI. Results In this study, meeting profiles major diagnostic parameters studied. center leaders reported patients’ data from 30 representing a total...
Background and Objectives: Parkinson's disease (PD) is a chronic, progressive illness with profound impact on health-related quality of life, it crucial to know what factors influence the life throughout course disease. This study aimed evaluate PD patients' motor non-motor symptoms compare symptom severity between clinical phenotypes assess in cohort Latvian patients. Materials Methods: We evaluated 43 patients Fourteen had tremor dominant (TD) PD, twenty-five postural instability/gait...
Currently, nanoparticles are widely present in the environment and being used various industrial technologies. Nanoparticles affect immune functions, causing different responses. The aim of current study was to evaluate several cytokines, interleukin (IL)-1b, IL-6, IL-8, tumour necrosis factor-a (TNF-α), interferon-γ, adhesive molecule sICAM-1, macrophage inhibitory protein 1a (MIP1a) secretory immunoglobulin A, nasal lavage fluid peripheral blood healthy subjects exposed workplace...
Introduction Hereditary angioedema (HAE) is a rare, life-threatening autosomal dominant genetic disorder caused by deficient and/or dysfunctional C1 esterase inhibitor (C1-INH) (type 1 and type 2) leading to recurrent episodes of edema. This study aims explore HAE patients’ metabolomic profiles identify novel potential diagnostic biomarkers for HAE. The also examined distinguishing from idiopathic (AE). Methods Blood plasma samples 10 (types 1/2) patients, 15 patients with AE, 20 healthy...
Abstract Background CRUSE® is an app that allows patients with chronic spontaneous urticaria (CSU) to monitor their daily disease activity through the use of visual analogue scales (VASs). We aimed determine concurrent validity, reliability, responsiveness and minimal important difference (MID) VASs. Method s evaluated properties three VASs: VAS for how much were affected by CSU (‘VAS urticaria’), impact on work/school productivity productivity’) EQ‐5D. Concurrent validity was assessed...
The aim of the present work was to characterize immune status 385 individuals who participated in 1986–90 clean‐up after effects Chernobyl nuclear power plant explosion. Fifty‐nine workers developed most common thyroid diseases; euthyroid nodular and diffuse goiter; 47 healthy blood donors were taken as controls. levels immunoglobulins (IgA, IgG IgM), numbers peripheral leukocytes, lymphocytes, monocytes, T lymphocytes their subpopulations (CD3+, CD4+, CD8+), B (CD19+), natural killer (NK)...
Computer work is characterized by sedentary static workload with low-intensity energy metabolism. The aim of our study was to evaluate the dynamics skin surface temperature in hand during prolonged computer mouse under different ergonomic setups. Digital infrared imaging right forearm and wrist performed three hours continuous (measured at start every 15 minutes thereafter) a laboratory controlled ambient conditions. Four people participated study. Three setups were tested on days...
The fluorescent probe ABM was used to characterize lymphocyte membranes and blood plasma albumin from cancer patients suffering colorectal or gastric cancers at Stages II-IV. aim of these studies evaluate the potential utility
Confocal micro-Raman and FT-IR spectroscopies have been used for detection of radiation influence hemoglobin patients examined by radio-isotopes diagnosis (Tc<sup>99m</sup>). After irradiation we observed some little changes the Raman scattering bands which connected with out plane porphyrine bending vibrations, also additional band due to methemoglobin. Radiation blood lead transition from (Fe<sup>2+</sup>) methemoglobin (Fe<sup>3+</sup>) a delocalization iron plane. It was shown that...