A5013239155- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Antimicrobial Resistance in Staphylococcus
- Nutrition, Genetics, and Disease
- Colorectal Cancer Treatments and Studies
- DNA Repair Mechanisms
- Global Cancer Incidence and Screening
- Streptococcal Infections and Treatments
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Colorectal Cancer Surgical Treatments
- CRISPR and Genetic Engineering
- Bacterial biofilms and quorum sensing
- Prostate Cancer Treatment and Research
- Helicobacter pylori-related gastroenterology studies
- Circular RNAs in diseases
- Genomic variations and chromosomal abnormalities
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- MicroRNA in disease regulation
- Viral gastroenteritis research and epidemiology
Riga Stradiņš University
2015-2025
Pauls Stradiņš Clinical University Hospital
2004-2019
The University of Queensland
2014
Hereditary Disease Foundation
2012
Karolinska Institutet
2011
Children's Clinical University Hospital
2009
Latvian Biomedical Research and Study Centre
2009
University of Latvia
2006
ABSTRACT The implementation of routine whole-genome sequencing (WGS) promises to transform our ability monitor the emergence and spread bacterial pathogens. Here we combined WGS data from 308 invasive Staphylococcus aureus isolates corresponding a pan-European population snapshot, with epidemiological resistance data. Geospatial visualization is made possible by generic software tool designed for public health purposes that available at project URL (...
Abstract Background Artificial intelligence (AI) has the potential to transform our healthcare systems significantly. New AI technologies based on machine learning approaches should play a key role in clinical decision-making future. However, their implementation health care settings remains limited, mostly due lack of robust validation procedures. There is need develop reliable assessment frameworks for AI. We present here an approach assessing predicting treatment response triple-negative...
Background/Objectives: MicroRNAs (miRNAs) are likely to play a significant role in the prediction of rectal cancer response chemoradiation therapy, offering insights that complement other biological tumour markers. The study aimed perform miRNA profiling tissues patients with good (GR) and bad (BR) neoadjuvant therapy (nCRT), select potentially clinically relevant ones, further evaluate their relationship subsequent disease outcomes survival prognosis. Methods: A total 40 selected locally...
Background/Objectives: The timely diagnostics of bladder cancer is still a challenge in clinical settings. reliability conventional testing methods does not reach desirable accuracy and sensitivity, it has an invasive nature. present study examines the application machine learning to improve by integrating miRNA expression levels, demographic routine laboratory test results, data. We proposed that merging these datasets would enhance diagnostic accuracy. Methods: This combined molecular...
fat Nodulation (Nod) factors are lipo-chitooligosaccharides (LCOs) secreted by rhizobia to trigger the early steps of nodule organogenesis in leguminous plants. A method synthesize LCOs vitro was developed. Synthetic alleviated requirement for auxin and cytokinin sustain growth cultured tobacco protoplasts. containing C(18:1) trans-fatty acyl substituents were more effective than those cis-fatty acids promoting cell division as well activating an auxin-responsive promoter expression a gene...
The outcome of the Chernobyl nuclear power plant (CNPP) accident was that a huge number people were exposed to ionizing radiation. Previous studies CNPP clean-up workers from Latvia revealed high occurrence age-associated degenerative diseases and cancer in young adults, as well mortality result cardiovascular disorders at age 45–54 years. DNA tandem repeats cap chromosome ends, known telomeres, are sensitive oxidative damage exposure Telomeres important aging processes carcinogenesis. aim...
Triple‑negative breast cancer (TNBC) is proposed to be an immunohistochemical surrogate of the basal‑like subtype. In spite relative chemosensitivity this subtype, it characterized by aggressive clinical behavior; therefore, a further subclassification TNBC required develop new targeted treatment. previous studies, strong correlation between BRCA1 mutation‑associated tumors and has been identified. The aim present study was investigate prognostic significance carrying two germline founder...
ABSTRACT An outbreak of hospital-acquired Acinetobacter baumannii infections, caused by a bla OXA-23 -positive carbapenem-resistant strain belonging to international clone II/ST2, was detected in Latvia. The partially equipped with the armA gene and intI1-aacA4-catB8-aadA1-qacE Δ 1 class integron. In addition, carried AbaR25, novel AbaR4-like resistance island ∼46,500 bp containing structures similar previously described AbaR22 Tn 6167 islands. AbaR25 characterized occurrence second copy...
Hereditary triple-negative breast cancer patients have better recurrence-free survival than sporadic ones. High expression of some the miRNAs is related to worse overall and disease-free patients. The attempt associate level miRNA in hereditary cancers disease specific was performed this study. Study group made 18 harboring BRCA1 gene mutations 32 Quantitative amount mir-10b, mir-21, mir-29a, mir-31, mir-214 by real-time PCR assessed. disease-specific relation high low levels analyzed using...
Abstract Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is a highly resistant and difficult to cure zoonotic microorganism, which makes up large part of food toxic infections has shown high prevalence among pig population all over the world. The aim study was establish occurrence MRSA in slaughterhouses, evaluate its antimicrobial resistance, verify whether there are any differences or similarities with reference other European countries. Material Methods: A total 100 pigs,...
Background and objectives: Cell culture is one of the mainstays in research breast cancer biology, although extent to which this approach allows preserve original characteristics originating tumor implications cell findings real life situations have been widely debated literature. The aim study was determine role three media on transcriptional expression markers reference lines (MCF7, SkBr3 MDA-MB-436). Materials methods: were conditioned studied (all containing 5% fetal bovine serum (FBS) +...
Infections by community-acquired methicillin resistant Staphylococcus aureus (CA-MRSA) have been reported worldwide. Here we present characterisation of the first CA-MRSA isolated in Latvia. A PVL-positive ST30-MRSA-IV strain was from a nasal swab and central venous catheter patient with fever multiple organ failure. The PFGE pattern this identical to SE00-3 MRSA Sweden 29 patients during 2000-2003. This is related South Pacific area, its appearance Latvia demonstrates global spread.
Mutations in the high penetrance breast and ovarian cancer susceptibility gene BRCA1 account for a significant percentage of hereditary cases. Genotype-phenotype correlations mutations located different parts have been described previously; however, phenotypic differences specific not yet fully investigated. In our study, based on analysis population-based series unselected cases Latvia, we show some aspects genotype-phenotype correlation among c.4034delA (4153delA) c.5266dupC (5382insC)...
There is increasing evidence of high platinum sensitivity in BRCA-associated breast cancer. However, from randomized trials lacking. The aim this study was to analyze the results platinum-based chemotherapy for BRCA1-positive cancer a neoadjuvant setting.A retrospective performed by obtaining information patient files. were compared with available data literature review.Twelve female patients BRCA1 gene mutations who had stage I III cancers eligible evaluation. They received between 2011 and...
In our previously reported study, we found a correlation between DNA massive fragmentation and increased progression free survival (PFS) in metastatic colorectal cancer (mCRC), but not overall survival. The aim of this study is to find overlapping deleted genome regions selected mCRC patients with chromothripsis detect possible cause PFS, new genes or combinations, involved oncogenesis. Materials Methods: 10 receiving 5-fluorouracil, oxaliplatin, leucovorin (FOLFOX) first-line palliative...
Introduction: Alteration of human gut microbiota is described in a number neuro-developmental and cognitive disorders including autistic spectrum disorder (ASD). Along with the changes microbiota, children ASD are also reported to have urinary organic acid spectra implying these metabolites as potential biomarkers for gastrointestinal dysbiosis.Aim: Identify that would indicate specific could be useful biomarkers.Methods: The study group consisted 44 ASD. Urinary acids composition were...
The non-operative management of rectal adenocarcinoma (RA) after neoadjuvant chemoradiation therapy (nCRT) has gained increasing attention. "Watch and Wait" ("W&W") strategy allows one to avoid surgery-related reduction in the quality life due permanent pelvic organ dysfunction or irreversible stoma. Still, oncological safety this is under evaluation.
We would like to present a patient with classical phenotype of rare disorder - Cowden syndrome, its diagnostics and management challenges. A breast surgeon has be aware this condition when treating manifestations syndrome refer the clinical geneticist for further evaluation. Sequencing PTEN gene showed Asp24Gly mutation. According latest literature data, lifetime risk cancer patients is 81% surgery justified option reduce cancer. Bilateral risk-reducing mastectomy immediate reconstruction...
Abstract Background The estimated ratio of hereditary breast/ovarian cancer (HBOC) based on family history is 1.5% in Latvia. This significantly lower than the European average 5–10%. Molecular markers like mutations and SNPs can help distinguish HBOC patients sporadic breast ovarian group. Methods 50 diagnosed with Latvian Cancer Registry from January 2005 to December 2008 were screened for BRCA1 founder mutation-negatives subjected targeted resequencing BRCA2 genes. newly found group 1075...
Metastatic dissemination of the primary tumor is major cause death in colorectal cancer (CRC) patients. Multiple chromosomal breaks and chromothripsis, a phenomenon involving multiple fragmentations occurring single catastrophic event, are associated with genesis, progression developing metastases. The aim this study was to evaluate effect chromothripsis total breakpoint count (breakpoint instability index) on progression‑free survival (PFS). A 19 patients metastatic CRC (mCRC) receiving...
Abstract Introduction It has not been established whether CHEK2 and NOD2 variants are present in Latvia inherited variation these genes influences cancer risk this population. Aim of the study To evaluate role mutations breast colorectal cancers population Latvia. Materials methods Peripheral venous blood samples were collected from 185 235 consecutive hospital-based cases 11/2003 to 06/2005. The control group included clamped distal part umbilical cord 978 anonymous newborns born between...
Introduction. Von Hippel-Lindau (VHL) syndrome is a pathological condition that causes various clinical symptoms and difficult to diagnose. The most common lesions are hemangioblastomas of the central nervous system, retinal angiomas, renal clear cell carcinomas, pheochromocytomas. Case Report. A 23-year-old female had syncope episode in 2008. Magnetic resonance imaging (MRI) revealed right temporal hemangioblastoma, which was treated surgically. Genetic screening identified VHL gene...