A5087921608- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
Riga Stradiņš University
2019-2020
In our previously reported study, we found a correlation between DNA massive fragmentation and increased progression free survival (PFS) in metastatic colorectal cancer (mCRC), but not overall survival. The aim of this study is to find overlapping deleted genome regions selected mCRC patients with chromothripsis detect possible cause PFS, new genes or combinations, involved oncogenesis. Materials Methods: 10 receiving 5-fluorouracil, oxaliplatin, leucovorin (FOLFOX) first-line palliative...
X-linked lymphoproliferative disease (XLP) is a rare primary immunodeficiency. Affected individuals usually present with the Epstein-Barr virus infection and have no apparent prior to presentation. The most common clinical manifestations are fulminant infectious mononucleosis, dysgammaglobulinaemia, lymphoma (usually of B-cell origin). XLP caused by mutations in SH2D1A gene which encodes intracellular adaptor molecule SAP (signalling lymphocyte activation molecule- (SLAM-) associated...