Annalisa Pantosti
A5024735046- Antimicrobial Resistance in Staphylococcus
- Pneumonia and Respiratory Infections
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Bacterial Infections and Vaccines
- Bacterial biofilms and quorum sensing
- Streptococcal Infections and Treatments
- Antibiotic Use and Resistance
- Clostridium difficile and Clostridium perfringens research
- Mycobacterium research and diagnosis
- Respiratory viral infections research
- Infective Endocarditis Diagnosis and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Enterobacteriaceae and Cronobacter Research
- Diphtheria, Corynebacterium, and Tetanus
- Viral gastroenteritis research and epidemiology
- Genomics and Phylogenetic Studies
- Antibiotics Pharmacokinetics and Efficacy
- Microbial Metabolism and Applications
- Vibrio bacteria research studies
- Escherichia coli research studies
- Gut microbiota and health
- Infections and bacterial resistance
- Antifungal resistance and susceptibility
- Probiotics and Fermented Foods
Istituto Superiore di Sanità
2015-2024
Società Italiana di Medicina Generale
2021
Institute of Studies for the Integration of Systems
2020
National Institute of Public Health
2020
Azienda Ospedaliera Sant'Andrea
2010
Ospedale Maggiore di Lodi
2009
University of Padua
2007
Ospedali Riuniti Umberto I
1994
Brigham and Women's Hospital
1991-1992
Sapienza University of Rome
1984-1989
Staphylococcus aureus is a typical human pathogen. Some animal S. lineages have derived from strains following profound genetic adaptation determining change in host specificity. Due to the close relationship of animals with environmental microbiome and resistome, staphylococcal also represent source resistance determinants. Methicillin-resistant (MRSA) emerged 50 years ago as nosocomial pathogen but last decade it has become frequent cause infections community. The recent finding that MRSA...
Consecutive non-replicate clinical isolates (n=191) of carbapenem non-susceptible Enterobacteriaceae were collected from 21 hospital laboratories across Italy November 2013 to April 2014 as part the European Survey on Carbapenemase-producing (EuSCAPE) project. Klebsiella pneumoniae carbapenemase-producing K. (KPC-KP) represented 178 (93%) with 76 (43%) respectively resistant colistin, a key drug for treating carbapenamase-producing Enterobacteriaceae. KPC-KP colistin-resistant detected in...
ABSTRACT The implementation of routine whole-genome sequencing (WGS) promises to transform our ability monitor the emergence and spread bacterial pathogens. Here we combined WGS data from 308 invasive Staphylococcus aureus isolates corresponding a pan-European population snapshot, with epidemiological resistance data. Geospatial visualization is made possible by generic software tool designed for public health purposes that available at project URL (...
To estimate the proportion of methicillin-resistant Staphylococcus aureus (MRSA) isolates from humans that were sequence type (ST) 398, we surveyed 24 laboratories in 17 countries Europe 2007. Livestock-associated MRSA ST398 accounted for only a small humans; most Netherlands, Belgium, Denmark, and Austria.
Carbapenem-resistant Enterobacteriaceae (CRE) are emerging as a public health problem in various settings. In Italy, rapid and remarkable increase of carbapenem-non-susceptible Klebsiella pneumoniae has been reported since 2010. Here we report on the results countrywide cross-sectional survey, carried out from 15 May to 30 June 2011 investigate diffusion CRE Italy characterise most prevalent resistance mechanisms their dissemination patterns. were (23 25) participating laboratories, with an...
The Bengal Bay clone (ST772) is a community-associated and multidrug-resistant Staphylococcus aureus lineage first isolated from Bangladesh India in 2004. In this study, we showed that the emerged virulent progenitor circulating on Indian subcontinent. Its subsequent global transmission was associated with travel or family contact region. ST772 progressively acquired specific resistance elements at limited cost to its fitness continues be exported globally, resulting small-scale community...
Significance In many clinically important bacteria, antibiotic resistance genes are primarily carried on plasmids. These can spread horizontally between different strains and species. However, current surveillance systems track chromosomal lineages of bacteria only, leading to an incomplete understanding how spreads, from within individual hospital across country borders. We present integrated, high-resolution analysis both chromosome plasmid sequences using Klebsiella pneumoniae isolates...
We investigated the evolution and epidemiology of a novel livestock-associated methicillin-resistant Staphylococcus aureus strain, which colonizes infects urban-dwelling Danes even without Danish animal reservoir. Genetic evidence suggests both poultry human adaptation, with meat implicated as probable source.
Current literature shows that secondary bacterial infections, although less frequent than in previous influenza pandemics, affect COVID-19 patients. Mycoplasma pneumoniae, Staphylococcus aureus, Legionella pneumophila, Streptococcus Haemophilus and Klebsiella spp. are the main species isolated. Of note, Mycobacterium tuberculosis-COVID-19 coinfections also reported. However, coinfection rates increase patients admitted intensive care units, those diseases can be due to super-infections by...
ABSTRACT Susceptibilities to macrolides were evaluated in 267 Streptococcus pneumoniae isolates, of which 182 from patients with invasive diseases and 85 healthy carriers. Of the 98 resistant 20 strains showed an M phenotype carried mef . Strains that both (A) (E) found: 17 3 (E). The characteristics carrying genes properties mef- containing elements studied. belonged serotype 14, susceptible all antibiotics tested except erythromycin, appeared be clonally related by pulsed-field gel...
ObjectivesThe aim of this study was to provide molecular characterization methicillin-resistant Staphylococcus aureus (MRSA) spa type t127, sequence (ST) 1 isolates, detected in a European baseline survey holdings breeding pigs, determine phenotypic and genotypic drug resistance compare the results with those obtained from collection ST1 MRSA methicillin-susceptible S. (MSSA) clinical isolates.
Currently, surveillance of livestock-associated meticillin-resistant Staphylococcus aureus (LA-MRSA) in humans Europe is not systematic but mainly event-based. In September 2014, the European Centre for Disease Prevention and Control (ECDC) initiated a questionnaire to collect data on number LA-MRSA from human samples (one isolate per patient) national/regional reference laboratories Union/European Economic Area (EU/EEA) countries 2013. Identification as clonal complex (CC) 398 by multilocus...
The spread of carbapenem-resistant Enterobacteriaceae (CRE) represents one the most worrisome problems for clinical medicine worldwide. In Italy, Antibiotic-Resistance-Istituto Superiore di Sanità surveillance network, in collaboration with Committee Antimicrobial Agents Italian Society Clinical Microbiologists, promoted a study to investigate carbapenem-resistance mechanisms, clonal relatedness and capsular typing recent collection Klebsiella pneumoniae (CR-KP). A total 17 laboratories...
In Tuscany, Italy, New Delhi metallo-beta-lactamase-producing carbapenem-resistant Enterobacterales (NDM-CRE) have increased since November 2018. Between 2018 and October 2019, 1,645 samples were NDM-CRE-positive: 1,270 (77.2%) cases of intestinal carriage, 129 (7.8%) bloodstream infections 246 (14.9%) infections/colonisations at other sites. Klebsiella pneumoniae prevalent (1,495; 90.9%), with ST147/NDM-1 the dominant clone. Delayed outbreak identification response resulted in sustained...
Following the rapid increase of infections due to carbapenemase-producing Enterobacteriaceae (CPE) in Italy, national surveillance bloodstream (BSI) CPE (Klebsiella pneumoniae and Escherichia coli) was instituted 2013. All CPE-BSI cases reported years 2014-17 were analysed order investigate incidence rate (IR), trend, main individual characteristics enzymes involved resistance. Throughout this period, 7,632 (IR: 3.14/100,000 inhabitants) from all 21 regions autonomous provinces with an...
Previous studies showed that the epidemic of carbapenem-resistant Klebsiella pneumoniae (CR-KP) observed in Italy since 2010 was sustained mostly by strains clonal group (CG) 258 producing KPC-type carbapenemases. In framework National Antibiotic-Resistance Surveillance (AR-ISS), a countrywide survey conducted 2016 to explore evolution phenotypic and genotypic characteristics CR-KP isolates.From March July 2016, hospital laboratories participating AR-ISS were requested provide consecutive,...