A5039577393- Influenza Virus Research Studies
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Viral gastroenteritis research and epidemiology
- Genomics and Phylogenetic Studies
- Zoonotic diseases and public health
- COVID-19 epidemiological studies
- Pneumonia and Respiratory Infections
- Virology and Viral Diseases
- Viral Infections and Immunology Research
- Bacterial Infections and Vaccines
- Avian ecology and behavior
- Vibrio bacteria research studies
- Plant Virus Research Studies
- Bacterial Genetics and Biotechnology
- Neonatal and Maternal Infections
- Peptidase Inhibition and Analysis
- Physiological and biochemical adaptations
- Mosquito-borne diseases and control
- Viral Infectious Diseases and Gene Expression in Insects
- COVID-19 diagnosis using AI
Finnish Institute for Health and Welfare
2021-2025
Helsinki University Hospital
2017-2022
University of Helsinki
2008-2022
Institute for Molecular Medicine Finland
2021-2022
Turku University Hospital
2021
European Centre for Disease Prevention and Control
2018-2021
Istituto Superiore di Sanità
2020-2021
Utrecht University
2013
Since mid-July 2023, an outbreak caused by highly pathogenic avian influenza A(H5N1) virus clade 2.3.4.4b genotype BB is ongoing among farmed animals in South and Central Ostrobothnia, Finland. Infections foxes, American minks raccoon dogs have been confirmed on 20 farms. Genetic analysis suggests introductions from wild birds scavenging for food farm areas. Investigations point to direct transmission between animals. While no human infections detected, control measures are being implemented...
A risk assessment framework was developed to evaluate the zoonotic potential of avian influenza (AI), focusing on virus mutations linked phenotypic traits related mammalian adaptation identified in literature. Virus sequences were screened for presence these and their geographical, temporal subtype-specific trends. Spillover events mammals (including humans) human seroprevalence studies also reviewed. Thirty-four associated with five (increased receptor specificity, haemagglutinin stability,...
Highly pathogenic avian influenza (HPAI) has caused widespread mortality in both wild and domestic birds Europe 2020-2023. In July 2023, HPAI A(H5N1) was detected on 27 fur farms Finland. total, infections silver blue foxes, American minks raccoon dogs were confirmed by RT-PCR. The pathological findings the animals include inflammatory lesions lungs, brain liver, indicating efficient systemic dissemination of virus. Phylogenetic analysis Finnish strains from identified three clusters...
Despite its popularity for water activities, such as swimming, surfing, fishing, and rafting, inland coastal bathing areas occasionally experience outbreaks of highly pathogenic avian influenza virus (HPAI), including A(H5N1) clade 2.3.4.4b. Asymptomatic infections symptomatic often impact many aquatic birds, which increase chances spill-over events to mammals pose concerns public health. This review examined the existing literature assess (AIV) transmission risks beachgoers general...
In 2023, Finland faced an outbreak of highly pathogenic avian influenza caused by clade 2.3.4.4b A(H5N1) viruses, which spread from wild birds to fur farms. Vaccinations individuals at-risk, such as and poultry farm workers, veterinarians, laboratory began in June 2024 using the MF59-adjuvanted inactivated (H5N8) vaccine manufactured Seqirus (based on A/Astrakhan/3212/2020). We investigated antibody responses following a two-dose vaccination regimen 39 subjects. Vaccination induced...
Chikungunya virus is an emerging mosquito-borne pathogen with a wide global distribution. With the severe morbidity that it causes, chikungunya major public health problem in affected areas and poses considerable risk for unaffected hosting competent vector populations. In summer of 2017, Italy experienced outbreak spread Lazio region caused secondary Calabrian village Guardavalle, final case number 436. The causative strain was recognized as Indian Ocean lineage (IOL) virus.To understand...
Previous studies showed that the epidemic of carbapenem-resistant Klebsiella pneumoniae (CR-KP) observed in Italy since 2010 was sustained mostly by strains clonal group (CG) 258 producing KPC-type carbapenemases. In framework National Antibiotic-Resistance Surveillance (AR-ISS), a countrywide survey conducted 2016 to explore evolution phenotypic and genotypic characteristics CR-KP isolates.From March July 2016, hospital laboratories participating AR-ISS were requested provide consecutive,...
Highly pathogenic avian influenza (HPAI) H5N1 is known for its virulence and zoonotic potential, infecting birds mammals, thus raising public health concerns. Since 2021 spread among has led to cross-species transmission causing epizootics eventually impacting fur animal farms in Finland 2023. To analyze the infectivity of Finnish isolates human cells, representatives diverse were selected based on genetic differences, host species, year occurrence. The infection kinetics from wild pheasant...
We report an adenovirus outbreak with unusually severe clinical presentation, particularly in military conscripts and their close contacts. During 1 February–30 June 2024, 129 patients infection were hospitalised, 30 admitted to ICU, 10 required ECMO treatment six died. Cases consisted of 75 (58.1%) 54 civilians (41.9%). Most samples type 7 (97/108; 89.8%); all 24 sequenced subtype 7d. August–30 November 274 additional hospitalised cases identified from registries.
Multiple introductions of SARS-COV-2 Omicron variant BA.1 and BA.1.1. lineages to Finland were detected in early December 2021. Within 3 weeks, overtook Delta as the most common capital region. Sequence analysis demonstrated emergence spread through community transmission a large cluster BA.1.1 virus.
ABSTRACT Newcastle disease (ND) is a highly contagious, severe of poultry caused by pathogenic strains virus (NDV; or avian paramyxovirus-1). NDV endemic in wild birds worldwide and one the economically most important pathogens. Most published are outbreak-associated strains, while apathogenic that occur birds, posing constant threat to with their capability convert into more virulent forms, have remained less studied. We screened for RNA cloacal oropharyngeal samples from waterfowl Finland...
Introduction: Migratory birds act as hosts for a number of zoonotic viruses, and have the ability to disperse these viruses distant geographic locations. Coronaviruses (CoVs) represent family with wide variety animal hosts, including humans. The infections caused by coronaviruses vary from mild severe, depending on viral species host. Since exhibit extraordinary large RNA genome, also rate homologous recombination is high, which in turn contributes genetic diversity interspecies...
Screening wild birds for viral pathogens has become increasingly important. We tested a screening approach based on blood and cloacal tracheal swabs collected by hunters to study the prevalence of influenza A, paramyxo-, flavi-, alphaviruses in Finnish waterfowl, which been previously unknown. studied 310 samples 115 mixed from hunted waterfowl 2006. Samples were screened RT-PCR serologically hemagglutination inhibition (HI) test or enzyme-linked immunosorbent assay (ELISA) A (FLUAV), type 1...
Severe acute respiratory syndrome coronavirus 2 Alpha and Beta variants became dominant in Finland spring 2021 but had diminished by summer. We used phylogenetic clustering to identify sources of spreading. found that outbreaks were mostly seeded a few introductions, highlighting the importance surveillance prevention policies.
Recombinant sequences of the SARS-CoV-2 Omicron variant were detected in surveillance samples collected north-western Finland January 2022. We 191 with an identical genome arrangement weeks 3 to 11, indicating sustained community transmission. The recombinant lineage has a 5'-end BA.1, recombination breakpoint between orf1a and orf1b (nucleotide position 13,296-15,240) 3'-end BA.2 including S gene. describe available genomic epidemiological data about this currently circulating XJ lineage.
The BamA protein is the key component of Bam complex, assembly machinery for outer membrane proteins (OMP) in gram-negative bacteria. We previously demonstrated that recognizes its OMP substrates a species-specific manner vitro. In this work, we further studied species specificity vivo by testing functioning homologs proteobacteria Neisseria meningitidis, gonorrhoeae, Bordetella pertussis, Burkholderia mallei, and Escherichia coli E. N. meningitidis. found no functioned another than...
We report cases of mammalian infection with highly pathogenic avian influenza (HPAI) virus A(H5N1) clade 2.3.4.4b in Northern Ireland. Two common gulls ( Larus canus ) and two red fox kits Vulpes vulpes ), were found dead close vicinity. Comparison viral whole genome sequences obtained from the animals identified a novel adaptation, PB2-M535I. Analysis genetic other recent infections shows that this mutation has arisen on at least five occasions three European countries since April 2023.
Invasive infections by group B streptococci (iGBS) are the leading cause of sepsis and meningitis in first three months life worldwide. The clinical microbiological characteristics neonatal infant iGBS Italy during years 2015-2019 were investigated. Voluntary-based surveillance reported 191 cases (67 early-onset (EOD) 124 late-onset disease (LOD)) 89 bacterial isolates received. main manifestations (59.2%) followed (21.5%), bacteremia (12.0%) septic shock (6.3%). Hospitalized preterm babies...
Influenza A viruses (IAVs) of the subtypes H13 and H16 are primarily found in gulls ( Larus spp., order Charadriiformes). Although gull-adapted replicate efficiently during infection, usually remain apparently healthy infection. Avian influenza virus isolates generally separated into two distinct populations, North American Eurasian, because limited gene flow between continents. Reassortment these lineages does occur occasionally; however, direct intercontinental transmission all eight...
Abstract Multiple introductions of SARS-COV-2 Omicron variant BA.1. and BA.1.1. lineages to Finland were detected early December 2021, comprised the majority over Delta in 3 weeks capital region. Our sequence analysis demonstrates emergence a large cluster BA.1.1 community transmission.
Enterovirus A71 (EV-A71) is among the most neuropathogenic non-polio enterovirus types and, in rare instances, can lead to severe or even fatal outcomes, particularly children under 5 years of age. This case study presents clinical and microbiological findings from initial documented pediatric EV-A71 Finland, identified May 2019. The near-complete genome sequence confirms that strain belongs newly recombinant C1-like genetic lineage, which emerged 2015 has since been circulating Europe,...