A5005121596- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Inflammatory Bowel Disease
- Microscopic Colitis
- Immune Response and Inflammation
- Viral Infections and Outbreaks Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- IL-33, ST2, and ILC Pathways
- Helicobacter pylori-related gastroenterology studies
- SARS-CoV-2 detection and testing
- Digestive system and related health
- Dengue and Mosquito Control Research
- Virology and Viral Diseases
- Gut microbiota and health
- Clinical Nutrition and Gastroenterology
- Poxvirus research and outbreaks
- Vector-borne infectious diseases
- Organoselenium and organotellurium chemistry
- Bacillus and Francisella bacterial research
- interferon and immune responses
- Insect symbiosis and bacterial influences
Istituto Superiore di Sanità
2016-2025
Istituto Nazionale di Statistica
2023
Ministry of Health
2023
Philadelphia University
2008
DuPont (United States)
1963
Experimental Station
1963
An autochthonous chikungunya outbreak is ongoing near Anzio, a coastal town in the province of Rome. The virus isolated from one patient and mosquitoes lacks A226V mutation belongs to an East Central South African strain. As 20 September, 86 cases are laboratory-confirmed. proximity capital, its late summer occurrence, diagnostic delays, favouring transmission. Vector control, enhanced surveillance restricted blood donations being implemented affected areas.
Mosquito-borne diseases are an emerging threat in Europe. West Nile virus (WNV) is arbovirus commonly transmitted enzootic cycle involving ornithophilic mosquitoes as major vectors. In recent years, global climate change has been identified a significant driver of the increased spread this virus. Italy, outbreaks WNV infection have recorded every year northern Italy. The Apulia region southern Italy was not considered high-risk until 2023, when unexpected increase infections occurred. aim...
Chikungunya virus is an emerging mosquito-borne pathogen with a wide global distribution. With the severe morbidity that it causes, chikungunya major public health problem in affected areas and poses considerable risk for unaffected hosting competent vector populations. In summer of 2017, Italy experienced outbreak spread Lazio region caused secondary Calabrian village Guardavalle, final case number 436. The causative strain was recognized as Indian Ocean lineage (IOL) virus.To understand...
The frequency of locally transmitted dengue virus (DENV) infections has increased in Europe recent years, facilitated by the invasive mosquito species Aedes albopictus, which is well established a large area Europe. In Italy, first indigenous outbreak was reported August 2020 with 11 acquired cases Veneto region (northeast Italy), caused DENV-1 viral strain closely related to previously described circulating Singapore and China. this study, we evaluated vector competence two Italian...
Abstract We performed a retrospective immunological analysis of the antibody response in serum and nasopharyngeal swabs (NPS) obtained from 46 individuals infected with ancestral SARS-CoV-2 Wuhan-Hu-1 strain during first COVID-19 wave Cagliari (Sardinia, Italy), 4-month follow-up after hospital admission. implemented comprehensive mucosal samples using assays established our laboratories. In NPS we evaluated viral load by real time PCR, presence kinetics anti-Spike IgG IgA ELISA as well...
CHIKV infection is transmitted by Aedes mosquitoes spp., with Ae. aegypti considered as the primary vector and Albopictus playing an important role in sustaining outbreaks Europe. The ECSA-Indian Ocean Lineage (IOL) strain emerged Reunion, subsequently spreading to areas such India, Indian Ocean, Southeast Asia, also causing naive countries, including more temperate regions, which originated from infected travelers. In Italy, two authocthounous occurred 2007 (Emilia Romagna region) 2017...
Type I interferon (IFN-I) evasion by Dengue virus (DENV) is key in DENV pathogenesis. The non-structural protein 5 (NS5) antagonizes IFN-I response through the degradation of signal transducer and activator transcription 2 (STAT2). We developed a K562 cell-based platform, for high throughput screening compounds potentially counteracting NS5-mediated antagonism signaling. Upon with library 1220 approved drugs, 3 previously linked to inhibition (Apigenin, Chrysin, Luteolin) were identified....
In 2017, a chikungunya outbreak in central Italy later evolved into secondary cluster southern Italy, providing evidence of disease emergence new areas. Officials have taken action to raise awareness among clinicians and the general population, increase timely case detection, reduce mosquito breeding sites, promote bite prevention.
Pandemic coronavirus disease 2019 (COVID-19) represents a challenge for healthcare structures. The molecular confirmation of samples from infected individuals is crucial and therefore guides public health decision making. Clusters possibly increased diffuse transmission could occur in the context next influenza season. For this reason, diagnostic test able to discriminate severe acute respiratory syndrome 2 (SARS-CoV-2) viruses urgently needed.
We compared the vector competence of an Italian population Aedes albopictus for two strains chikungunya virus (CHIKV), with and without E1:A226V mutation, responsible outbreaks in 2007 Emilia Romagna region 2017 Lazio Calabria regions, respectively. Ae. showed similar both viral indicating that mutation is not exclusively ability CHIKV to replicate well this mosquito species.
Chikungunya virus (CHIKV) is an emerging arbovirus, belonging to the Togaviridae family, Alphavirus genus, transmitted by Aedes spp. mosquitoes. Since 2007, two different CHIKV strains (E1-226A and E1-226V) have been responsible for outbreaks in European countries, including Italy, sustained Ae. albopictus mosquitoes.In this study, we assessed susceptibility E1-226V, strain Italian 2007 outbreak, of eight populations collected Northern, Central, Southern, Island experimental infections....
Abstract Background On 11 March 2020, the World Health Organisation (WHO) declared coronavirus disease 2019 (COVID-19) outbreak to be a pandemic. As mosquito season progressed, understandable concern that mosquitoes could transmit virus began increase among general public and health organisations. We have investigated vector competence of Culex pipiens Aedes albopictus , two most common species in Europe, for severe acute respiratory syndrome 2 (SARS-CoV-2). Due very unusual feeding...
Background: A CD4+CD25- regulatory T cell population expressing the surface TGF-β in its latent form LAP+ [latency associated peptide] cells was proved to be protective experimental colitis and suppressive of human peripheral blood [PB] proliferation. We investigated frequency function lamina propria [LP] CD4+LAP+ inflammatory bowel disease [IBD] patients.
To evaluate whether antibodies specific for the vaccinia virus (VV) are still detectable after at least 45 years from immunization. confirm that VV-specific endowed with capacity to neutralize Mpox (MPXV) in vitro. test a possible role of polyclonal non-specific activation maintenance immunologic memory.
Dengue (DENV) and Zika (ZIKV) viruses are mosquito-borne human pathogens. In Italy, the presence of competent vector Aedes albopictus increases risk autochthonous transmission, a national plan for arboviruses prevention, surveillance, response (PNA 2020–2025) is in place. The results laboratory diagnosis both by National Reference Laboratory (NRLA) from November 2015 to 2022 presented. Samples 655 suspected cases were tested molecular serological assays. Virus antibody kinetics,...
Several flaviviruses such as Hepatitis C virus, West Nile Dengue virus and Japanese Encephalitis exploit the raft platform to enter host cells whereas involvement of lipid rafts in Zika virus–host cell interaction has not yet been demonstrated. disease is caused by a flavivirus transmitted Aedes spp. Mosquitoes, although other mechanisms blood transfusion, sexual maternal–fetal transmission have Symptoms are generally mild, fever, rash, joint pain conjunctivitis, but neurological...
Toscana Virus (TosV) was firstly isolated from phlebotomine in our Institute about fifty years ago. Later, 1984-1985, TosV infection, although asymptomatic most cases, shown to cause disease humans, mainly fever and meningitis. By means of genetic analysis part M segment, we describe 3 new viral isolates obtained directly cerebrospinal fluid or sera samples patients diagnosed with infection July 2020 Tuscany region. Phylogenesis used propose the clustering lineage A strains main groups,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Crystal Structure of 1,4-Diselenane TetrachlorideA. Amendola, E. S. Gould, and B. PostCite this: Inorg. Chem. 1964, 3, 8, 1199–1200Publication Date (Print):August 1, 1964Publication History Published online1 May 2002Published inissue 1 August 1964https://pubs.acs.org/doi/10.1021/ic50018a034https://doi.org/10.1021/ic50018a034research-articleACS PublicationsRequest reuse permissionsArticle Views24Altmetric-Citations10LEARN ABOUT THESE...
The emergence of Zika virus in the Americas has caused an increase babies born with microcephaly or other neurological malformations. differential diagnosis infection, particularly serological diagnosis, is important but complex issue. In this study, we describe clinical manifestations 94 suspected cases congenital from Bahia state, Brazil, and results tests performed on children and/or their mothers at average 71 days after birth. Anti-Zika immunoglobulin M (IgM) antibodies were detected...
Recent data show that regulatory cells with transforming growth factor (TGF)-β1-dependent activity are able to restore self-tolerance in overtly diabetic non-obese (NOD) mice. Thus, TGF-β1 seems have a relevant role protection from autoimmune diabetes. Our aim was investigate the possible significance of serum measurement natural history diabetes NOD mice, as well children positive for at least one islet-related antibody. Serum (both total and active) measured by enzyme-linked immunosorbent...
Background & Aims: In ulcerative colitis (UC), inflammation begins in the rectum and can extend proximally throughout entire colon. The extension of is an important determinant disease course, may be limited by action regulatory T cells (Tregs). this cross-sectional study, we evaluated relationship between UC proportions CD3+CD4+Foxp3+ CD3+CD4+LAP+Foxp3-Tregs colonic lamina propria (LP) 79 patients 29 controls. role these was also investigated murine oxazolone-induced model. Methods:...