A5056617782- SARS-CoV-2 and COVID-19 Research
- Temporomandibular Joint Disorders
- Calcium signaling and nucleotide metabolism
- Bacterial Infections and Vaccines
- Toxin Mechanisms and Immunotoxins
- Cleft Lip and Palate Research
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- Orthodontics and Dentofacial Orthopedics
- Autoimmune and Inflammatory Disorders Research
- Craniofacial Disorders and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Ion Channels and Receptors
- Neurogenetic and Muscular Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- Endoplasmic Reticulum Stress and Disease
- Voice and Speech Disorders
- Pneumonia and Respiratory Infections
- Peripheral Neuropathies and Disorders
- Facial Nerve Paralysis Treatment and Research
- SARS-CoV-2 detection and testing
- Cell death mechanisms and regulation
- Inclusion and Disability in Education and Sport
- COVID-19 Clinical Research Studies
Istituto Superiore di Sanità
2000-2025
University of Chieti-Pescara
2021-2023
Cell-mediated immunity (CMI) and antibody responses to Bordetella pertussis antigens were assessed 4-6 years after primary infant immunization with diphtheria-tetanus tricomponent acellular (DTaP) or (DT) vaccine in a country high endemicity of B. infection. CMI the (especially toxin [PT]) was more frequent and/or intense DTaP than DT recipients. No lymphoproliferation differences found between those without history although recipients produced very little interferon-gamma antigen...
The capacity of pertussis toxin (PT) to induce maturation and functional activities human monocyte–derived dendritic cells (DCs) was investigated. Both native PT (nPT) genetically detoxified (dPT) efficiently promoted expression on DCs CD80, CD86, leukocyte antigen–DR, CD83 markers, alloreactive antigen presentation, cytokine production, primarily interferon (IFN)–γ. Although they did not affect interleukin (IL)–10 production by lipopolysaccharide (LPS)–stimulated DCs, both nPT dPT strongly...
Abstract We performed a retrospective immunological analysis of the antibody response in serum and nasopharyngeal swabs (NPS) obtained from 46 individuals infected with ancestral SARS-CoV-2 Wuhan-Hu-1 strain during first COVID-19 wave Cagliari (Sardinia, Italy), 4-month follow-up after hospital admission. implemented comprehensive mucosal samples using assays established our laboratories. In NPS we evaluated viral load by real time PCR, presence kinetics anti-Spike IgG IgA ELISA as well...
(1) We aimed to compare articular eminence inclination (AEI) in normo-divergent subjects (SN^GoGn = 32° ± 5°), with different anteroposterior sagittal skeletal classes through a cone beam computed generated tomography (CBCT). (2) In this cross-sectional study, CBCT records were retrospectively analysed. From the original sample of 52 records, 33 adult selected (11 Class I, 13 II and 9 III). On mid-sagittal section Temporomandibular Joint (TMJ) on both sides, AEI was calculated by graphic...
In addition to its catalytic activities as ecto‐NAD + glycohydrolase (NADase), CD38 displays the ability transduce signals of biological relevance. Indeed, ligation on peripheral blood mononuclear cells (PBMC) by agonistic monoclonal antibodies (mAbs) is followed transcription and secretion a vast array regulatory cytokines. The present work addresses issue whether leading calcium (Ca 2+ ) mobilization, lymphocyte proliferation release cytokines dependent epitopes recognized individual mAbs....
To investigate temporomandibular joint (TMJ) involvement signs such as muscle pain, the ratio of masseter and temporal activity, mouth opening width jaw deviation during in children adolescents with juvenile idiopathic arthritis (JIA), a group 32 subjects JIA control healthy were evaluated. Data collected clinically by palpation (masseters, anterior temporalis sternocleidomastoids) instrumental analysis (electromyography kinesiography). Higher pain was registered sternocleidomastoid muscles...
(1) Background: The aim of the study was to assess potential effectiveness clinical diagnostic examinations, such as muscle palpation, and instrumental electromyography, in early detection TMJ involvement patients with juvenile idiopathic arthritis (JIA), diagnosis these disorders can reduce risk developing facial growth anomalies dento-skeletal malocclusions. (2) Methods: Evaluations were conducted on a cohort 15 people (JIA) comparison group healthy participants at start trial (T0) after...
Abstract Background : Handwriting represents a cultural invention on which our society is based. According to western literate community, children acquire it during the primary school years, and based mechanisms inherent in biology from both cognitive motor perspective. Previous findings enhanced how handwriting skills are influenced by different ergonomic factors such as body posture. In this context there various studies that attempt show relationship between Stomatognathic Apparatus...