A5036327076- Influenza Virus Research Studies
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Animal Disease Management and Epidemiology
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Immune Response and Inflammation
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Immunodeficiency and Autoimmune Disorders
- Zoonotic diseases and public health
- Immunotherapy and Immune Responses
Erasmus University Rotterdam
2024
Erasmus MC
2024
Icahn School of Medicine at Mount Sinai
2021-2023
Leiden University Medical Center
2021
Messenger RNA (mRNA) vaccines represent a new, effective vaccine platform with high capacity for rapid development. Generation of universal influenza virus the potential to elicit long-lasting, broadly cross-reactive immune responses is necessity reducing influenza-associated morbidity and mortality. Here we focus on development B based lipid nanoparticle-encapsulated nucleoside-modified mRNA (mRNA-LNP) platform. We evaluate candidates different target antigens that afford protection against...
Combined vaccine formulations targeting not only hemagglutinin but also other influenza virus antigens could form the basis for a universal that has potential to elicit long-lasting, broadly cross-reactive immune responses. Lipid nanoparticle (LNP)-encapsulated messenger RNA (mRNA) vaccines can be utilized efficiently target multiple with single vaccine. Here, we assessed immunogenicity and protective efficacy of nucleoside-modified mRNA-LNP contain four A group 2 (hemagglutinin stalk,...
In 2023, Finland faced an outbreak of highly pathogenic avian influenza caused by clade 2.3.4.4b A(H5N1) viruses, which spread from wild birds to fur farms. Vaccinations individuals at-risk, such as and poultry farm workers, veterinarians, laboratory began in June 2024 using the MF59-adjuvanted inactivated (H5N8) vaccine manufactured Seqirus (based on A/Astrakhan/3212/2020). We investigated antibody responses following a two-dose vaccination regimen 39 subjects. Vaccination induced...
Summary In this study we profiled vaccine-induced polyclonal antibodies as well plasmablast derived mAbs from individuals who received SARS-CoV-2 spike mRNA vaccine. Polyclonal antibody responses in vaccinees were robust and comparable to or exceeded those seen after natural infection. However, the ratio of binding neutralizing vaccination was greater than that infection and, at monoclonal level, found majority did not have activity. We also a co-dominance targeting NTD RBD an original...
Currently, many groups are focusing on isolating both neutralizing and non-neutralizing antibodies to the mutation-prone hemagglutinin as a tool treat or prevent influenza virus infection. Less is known about level of protection induced by that target conserved internal proteins. Such could provide an alternative pathway induce broad cross-reactive against multiple serotypes subtypes partially overcoming escape mediated antigenic drift shift. Accordingly, more information potential...
Background: Highly pathogenic avian influenza (HPAI) H5 viruses of the A/Goose/Guangdong/1/1996 (GsGd) lineage pose significant global risks to wildlife, domestic animals, and humans. Recent cross-species transmission events mammals, including humans, highlight this risk. Critical determinants for intra-species include ability attach replicate in respiratory epithelial cells. Although these factors have been studied HPAI H5N1 past, limited studies are available currently circulating strains....
Abstract An increase in spillover events of highly pathogenic avian influenza A(H5N1) viruses to mammals suggests selection that transmit well mammals. Here we use air-sampling devices continuously sample infectious expelled by experimentally infected ferrets. The resulting quantitative virus shedding kinetics data resembled ferret-to-ferret transmission studies and indicated the absence observed for earlier was due a lack air, rather than necessary mammalian adaptation mutations. Whereas...
Abstract Highly pathogenic avian influenza A(H5) viruses globally impact wild and domestic birds, mammals, including humans, underscoring their pandemic potential. The antigenic evolution of the hemagglutinin (HA) poses challenges for preparedness vaccine design. Here, global HA was captured in a high-resolution map. map used to engineer immunogenic antigenically central antigens, eliciting antibody responses that broadly cover space. In ferrets, antigen protected as well homologous vaccines...