A5027400485- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Insect symbiosis and bacterial influences
- Zoonotic diseases and public health
- Genomics and Phylogenetic Studies
- Plant Virus Research Studies
- Yersinia bacterium, plague, ectoparasites research
- Malaria Research and Control
- BRCA gene mutations in cancer
- Animal Disease Management and Epidemiology
- COVID-19 diagnosis using AI
- Bacteriophages and microbial interactions
- Genetic factors in colorectal cancer
- SARS-CoV-2 detection and testing
- DNA Repair Mechanisms
University of Helsinki
2020-2024
Helsinki University Hospital
2021-2023
Turku University Hospital
2021
Finnish Institute for Health and Welfare
2021
Institute for Molecular Medicine Finland
2021
RNA viromes of nine commonly encountered Ochlerotatus mosquito species collected around Finland in 2015 and 2017 were studied using next-generation sequencing. Mosquito homogenates sequenced from 91 pools comprising 16–60 morphologically identified adult females Oc. cantans, caspius, communis, diantaeus, excrucians, hexodontus, intrudens, pullatus punctor/punctodes. In total 514 viral Reverse dependent polymerase (RdRp) sequences 159 virus recovered, belonging to 25 families or equivalent...
Sindbis virus (SINV) caused a large outbreak in Finland 2021 with 566 laboratory-confirmed human cases and notable geographical expansion. Compared the last 2002, incidence was higher several hospital districts but lower traditionally endemic locations eastern parts of country. A high is also expected 2022. Awareness SINV should be raised to increase recognition disease prevent transmission through promotion control measures.
Severe acute respiratory syndrome coronavirus 2 Alpha and Beta variants became dominant in Finland spring 2021 but had diminished by summer. We used phylogenetic clustering to identify sources of spreading. found that outbreaks were mostly seeded a few introductions, highlighting the importance surveillance prevention policies.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of infections and fatalities globally since its emergence in late 2019. The virus was first detected Finland January 2020, after which it rapidly spread among the populace spring. However, compared to other European nations, had a low incidence SARS-CoV-2. To gain insight into origins turnover SARS-CoV-2 lineages circulating we investigated phylogeographic -dynamic history virus.The introductions were inferred...
Sindbis virus (SINV) is a mosquito-borne avian hosted that widely distributed in Europe, Africa, Asia, and Oceania. Disease humans documented mainly from Northern Europe South Africa associated with genotype I. In 2018 under extremely warm climatic conditions, small outbreak of 71 diagnosed SINV infections was recorded Finland. We screened 52 mosquito pools (570 mosquitoes) 223 human sera for real-time RT-PCR the positive samples isolation. One strain isolated pool (
Pogosta disease is a mosquito-borne infection, caused by Sindbis virus (SINV), which causes epidemics of febrile rash and arthritis in Northern Europe South Africa. Resident grouse migratory birds play significant role as amplifying hosts various mosquito species, including Aedes cinereus, Culex pipiens, Cx. torrentium Culiseta morsitans are documented vectors. As specific treatments not available for SINV infections, joint symptoms may persist, the public health burden considerable endemic...
Abstract In search of novel breast cancer (BC) risk variants, we performed a whole-exome sequencing and variant analysis 69 Finnish BC patients as well analysed loss-of-function variants identified in DNA repair genes the Finns from Genome Aggregation Database. Additionally, carried out validation study SERPINA3 c.918-1G>C, recently suggested for predisposition. We estimated frequencies 41 rare candidate 38 by genotyping them 2482–4101 1273–3985 controls. further evaluated all coding...
Negeviruses are insect-specific enveloped RNA viruses that have been detected in mosquitoes and sandflies from various geographical locations. Here, we describe a new negevirus Northern Europe, isolated pool of Aedes vexans collected Finland, designated as Mekrijärvi (MEJNV). MEJNV had typical genome organization, is 9,740 nucleotides length, has GC content 47.53%. The contains three ORFs, each containing the following identified conserved domains: ORF1 (7,068 nt) encodes viral...
Complete genome data for the globally distributed Aedes flavivirus (AEFV) is scarce. We analyzed a new Italian AEFV strain isolated from
Abstract Finland has had a low incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infections as compared to most European countries. Here we report the origins and turnover SARS-CoV-2 lineages circulating in 2020. introduced January 2020 spread rapidly across southern during spring. We observed rapid among Finnish this period. Clade 20C became prevalent sequenced cases was replaced by other strains fall Bayesian phylogeographic reconstructions suggested 42 independent...
Abstract Two SARS-CoV-2 Variants of Concern, Alpha (~ 80%) and Beta 23%) rapidly became dominant in Finland the spring 2021 but diminished near summer. To assess their temporal epidemiological dynamics among Finnish cases, we began large-scale sequencing efforts to identify spreading events sources via phylogenetic clustering analyses. The results show majority belonged clusters community while few sequenced samples were singletons. highlight importance surveillance preventative policies...