A5028262328- Hidradenitis Suppurativa and Treatments
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Colorectal and Anal Carcinomas
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Hibiscus Plant Research Studies
- NF-κB Signaling Pathways
- Viral Infections and Immunology Research
- Autoimmune and Inflammatory Disorders Research
- Microscopic Colitis
- Autoimmune Bullous Skin Diseases
- interferon and immune responses
- Autoimmune and Inflammatory Disorders
- Toxoplasma gondii Research Studies
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- Mast cells and histamine
Humboldt-Universität zu Berlin
2023-2024
Charité - Universitätsmedizin Berlin
2017-2024
Freie Universität Berlin
2023-2024
Fraunhofer Institute for Translational Medicine and Pharmacology
2024
Acne inversa (AI)/hidradenitis suppurativa is a chronic inflammatory disease characterized by painful axillary, inguinal and perianal skin lesions with deep-seated nodules, abscesses fistulae.This study aimed to identify characterize the key players in AI pathogenesis.Epidemiological anamnestic data for patients were collected, blood samples also taken. Healthy participants psoriasis served as controls. Assessment of cultures primary cells was performed enzyme-linked immunosorbent assay,...
Hidradenitis suppurativa (HS) is a chronic inflammatory disease, characterized by painful, purulent and destructive skin alterations in intertriginous areas.We investigated the expression role HS of granulocyte colony-stimulating factor (G-CSF), regulator neutrophil biology, as clinical signs neutrophilic granulocyte-driven inflammation are distinctive disease.Skin blood samples obtained from different cohorts patients with control individuals were assessed RNA sequencing, quantitative...
Abstract Psoriasis is a chronic inflammatory disease resulting from dysregulated immune activation associated with large local secretion of cytokines. Among them, IL-22 largely contributes to epithelial remodeling and inflammation through inhibiting the terminal differentiation keratinocytes inducing antimicrobial peptides selected chemokines. The activity regulated by binding protein (IL-22BP); however, expression role IL-22BP in psoriatic skin has remained unknown so far. Here we showed...
BackgroundSchnitzler syndrome (SchS) is a rare autoinflammatory disease characterized by urticarial exanthema, bone and joint alterations, fever monoclonal gammopathy, which manifest mostly in the second half of life. It involves overactivation interleukin (IL)‐1 system, but exact pathophysiological pathways remain largely unknown.
Abstract Background CRUSE® is an app that allows patients with chronic spontaneous urticaria (CSU) to monitor their daily disease activity through the use of visual analogue scales (VASs). We aimed determine concurrent validity, reliability, responsiveness and minimal important difference (MID) VASs. Method s evaluated properties three VASs: VAS for how much were affected by CSU (‘VAS urticaria’), impact on work/school productivity productivity’) EQ‐5D. Concurrent validity was assessed...
CD44 is a transmembrane molecule appearing in numerous isoforms generated by insertions of alternatively spliced variant exons (CD44v) and having various binding partners. CD44v7 on T cells was proposed to promote colitis preventing T-cell apoptosis. Here we demonstrate that Cd44v7-deficient - like Cd44 wild-type (Cd44WT) provoked disease two different models: the model induced CD4+CD45RBhigh transfer into Rag2-deficient mice new based ovalbumin (OVA)-specific Rag-sufficient, OVA-challenged...
Schnitzler syndrome is a very rare chronic disease, which usually develops in the second half of life. It appears as skin rashes, muscle/skeletal pain and fever episodes. The trigger molecular processes disease are not understood. However, drugs that inhibit inflammatory molecule called interleukin‐1ß were found to relieve disease. authors this German study wondered further molecules involved syndrome. For purpose, range with properties was quantified blood patients and, comparison, healthy...
Schnitzler 综合征是一种非常罕见的慢性病,通常在后半生发生。它表现为皮疹、肌肉/骨骼疼痛和发热。此病的触发因素和分子过程尚不清楚。但是,发现抑制名为白介素‐1ß 炎症分子的药物可缓解此病。这项德国研究的作者想知道是否还有其他分子与 综合征有关。为此,在患者血液中定量分析了一系列有炎症性质的分子,作为比较,还在健康人和其他炎症疾病患者中进行了此定量分析。发现 综合征患者的 CCL2 水平明显增高,CCL2 是一种已知会把炎症细胞吸引到受影响组织附近并在骨变化中发挥特殊作用的分子。在被严重影响的患者中(尤其是在有剧烈骨痛的患者中),CCL2 的水平尤其高。在骨骼中,已知 由某些骨骼修饰细胞生成。实验室试验显示,免疫细胞和结缔组织细胞(纤维母细胞)也大量生成 CCL2。白介素‐1ß 以及炎症分子 TNF‐α 触发这些细胞生成 CCL2。当用白介素‐1ß‐阻滞药物治疗这些患者时,健康状况得到改善,同时 水平下降。作者们得出结论称,在 综合征中,CCL2 是骨骼和其他身体部位炎症过程中的重要一员,可在临床中作为一个疾病严重程度指标。