A5015110970- Inflammasome and immune disorders
- Cutaneous lymphoproliferative disorders research
- Mast cells and histamine
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Viral Infections and Immunology Research
- Toxoplasma gondii Research Studies
- Nail Diseases and Treatments
- Allergic Rhinitis and Sensitization
- Immune Cell Function and Interaction
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune and Inflammatory Disorders Research
Fraunhofer Institute for Translational Medicine and Pharmacology
2022-2023
Charité - Universitätsmedizin Berlin
2018-2023
Freie Universität Berlin
2022
Humboldt-Universität zu Berlin
2022
BackgroundSchnitzler syndrome (SchS) is a rare autoinflammatory disease characterized by urticarial exanthema, bone and joint alterations, fever monoclonal gammopathy, which manifest mostly in the second half of life. It involves overactivation interleukin (IL)‐1 system, but exact pathophysiological pathways remain largely unknown.
Introduction In mycosis fungoides (MF), the most common cutaneous T-cell lymphoma, itch is a frequent clinical symptom. Whether mast cells (MCs), eosinophils (Eos) or their mediators play role in MF-associated disease severity controversially discussed. Here, we explored of MC and Eo numbers skin as well blood levels itch. Methods 10 patients with MF matched control subjects assessed severity, itch, quality life impairment using dedicated tools such mSWAT, ItchyQoL DLQI. We analyzed biopsies...
Background Mycosis fungoides (MF) is an indolent T-cell lymphoma that mainly affects the skin and presents with itch in more than half of patients. Recently, expression Mas-related G protein-coupled receptor X2 (MRGPRX2), a mast cell (MC) responsible for IgE-independent non-histaminergic itch, has been shown lesional patients pruritic diseases, including chronic urticaria, prurigo, mastocytosis. As yet, limited knowledge exists regarding MRGPRX2 MF. Objectives To investigate number...
Schnitzler syndrome is a very rare chronic disease, which usually develops in the second half of life. It appears as skin rashes, muscle/skeletal pain and fever episodes. The trigger molecular processes disease are not understood. However, drugs that inhibit inflammatory molecule called interleukin‐1ß were found to relieve disease. authors this German study wondered further molecules involved syndrome. For purpose, range with properties was quantified blood patients and, comparison, healthy...
Schnitzler 综合征是一种非常罕见的慢性病,通常在后半生发生。它表现为皮疹、肌肉/骨骼疼痛和发热。此病的触发因素和分子过程尚不清楚。但是,发现抑制名为白介素‐1ß 炎症分子的药物可缓解此病。这项德国研究的作者想知道是否还有其他分子与 综合征有关。为此,在患者血液中定量分析了一系列有炎症性质的分子,作为比较,还在健康人和其他炎症疾病患者中进行了此定量分析。发现 综合征患者的 CCL2 水平明显增高,CCL2 是一种已知会把炎症细胞吸引到受影响组织附近并在骨变化中发挥特殊作用的分子。在被严重影响的患者中(尤其是在有剧烈骨痛的患者中),CCL2 的水平尤其高。在骨骼中,已知 由某些骨骼修饰细胞生成。实验室试验显示,免疫细胞和结缔组织细胞(纤维母细胞)也大量生成 CCL2。白介素‐1ß 以及炎症分子 TNF‐α 触发这些细胞生成 CCL2。当用白介素‐1ß‐阻滞药物治疗这些患者时,健康状况得到改善,同时 水平下降。作者们得出结论称,在 综合征中,CCL2 是骨骼和其他身体部位炎症过程中的重要一员,可在临床中作为一个疾病严重程度指标。