Hanna Bonnekoh
A5041500217- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Inflammasome and immune disorders
- Dermatology and Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mast cells and histamine
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- IL-33, ST2, and ILC Pathways
- Nail Diseases and Treatments
- Autoimmune and Inflammatory Disorders
- Otitis Media and Relapsing Polychondritis
- Hidradenitis Suppurativa and Treatments
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Eosinophilic Disorders and Syndromes
- Cutaneous lymphoproliferative disorders research
- Skin Diseases and Diabetes
- Sarcoidosis and Beryllium Toxicity Research
- Drug-Induced Adverse Reactions
- Eosinophilic Esophagitis
- Food Allergy and Anaphylaxis Research
- Medicine and Dermatology Studies History
- Plant chemical constituents analysis
- Infections and bacterial resistance
Charité - Universitätsmedizin Berlin
2015-2025
Fraunhofer Institute for Translational Medicine and Pharmacology
2021-2025
Humboldt-Universität zu Berlin
2018-2025
Freie Universität Berlin
2018-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2019
The COVID-19 pandemic dramatically disrupts health care around the globe. impact of on chronic urticaria (CU) and its management are largely unknown.To understand how CU patients affected by pandemic; specialists alter patient management; course in with COVID-19.Our cross-sectional, international, questionnaire-based, multicenter UCARE COVID-CU study assessed consultations, remote treatment, changes medications, clinical consequences.The severely impairs care, less than 50% weekly numbers...
Schnitzler's syndrome is a rare autoinflammatory disorder characterized by interleukin-1ß-mediated and neutrophil-dominated inflammation. Neutrophil extracellular traps (NETs) are web-like structures of decondensed chromatin, histones antimicrobial peptides released neutrophils. NETs were initially described in the context pathogen defense but also involved autoimmune-mediated skin diseases. Here, we assessed role neutrophil trap formation (NETosis) syndrome. Immunofluorescence co-staining...
Abstract Hereditary autoinflammatory diseases are caused by gene mutations of the innate immune pathway, e.g. nucleotide receptor protein 3 (NLRP3). Here, we report a four-generation family with cold-induced urticarial rash, arthralgia, chills, headache and malaise associated an autosomal-dominant inheritance. Genetic studies identify substitution mutation in F12 ( T859A , resulting p. W268R ) which encodes coagulation factor XII (FXII). Functional analysis reveals enhanced autocatalytic...
Indolent systemic mastocytosis (ISM) is characterized by excessive mast cell (MC) accumulation and MC-driven signs symptoms. Currently used therapies are not approved have limited efficacy. Lirentelimab (AK002) a monoclonal antibody against sialic acid-binding immunoglobulin-like lectin (Siglec)-8 that inhibits MC activation.To determine the safety, tolerability efficacy of lirentelimab in reducing symptoms ISM.At specialty centre for Germany, we conducted phase I first-in-human...
Importance Chronic prurigo (CPG), including nodularis, is a difficult disease to treat and considerably affects patients’ quality of life. Helping patients obtain control CPG major treatment goal. Objective To develop validate the Prurigo Control Test (PCT), tool for assessing in CPG, identify cutoff value controlled aid decisions. Design, Setting, Participants This qualitative study followed current recommendations patient-reported outcome measure development generation validation PCT. The...
Urticarial vasculitis (UV) is a rare type of leukocytoclastic characterized by long lasting urticarial skin lesions and poor response to treatment. As yet, no clinical guidelines, diagnostic criteria, or treatment algorithms exist, the approaches workup UV patients may differ globally. We conducted an online survey examine how are diagnosed treated international specialists reveal greatest challenges in managing worldwide.
BackgroundPatient-reported outcome measures (PROMs) are validated and standardized tools that complement physician evaluations guide treatment decisions. They crucial for monitoring atopic dermatitis (AD) chronic urticaria (CU) in clinical practice, but there unmet needs knowledge gaps regarding their use practice.ObjecctiveWe investigated the global real-world of AD CU PROMs allergology dermatology clinics as well associated local regional networks.MethodsAcross 72 specialized allergy...
The Angioedema Control Test (AECT) is a patient-reported outcome measure developed and validated for the assessment of disease control in patients with recurrent angioedema. Its sensitivity to change minimal clinically important difference (MCID) have hitherto not been established.
Abstract Background The pathogenesis of contact dermatitis, a common inflammatory skin disease with limited treatment options, is held to be driven by inflammasome activation induced allergens and irritants. We here aim identify inflammasome‐targeting strategies for irritant dermatitis. Methods A high content screen 41,184 small molecules was performed using fluorescent Apoptosis associated speck‐like protein containing CARD (ASC) speck formation as readout activation. Hit compounds were...
Urticarial vasculitis (UV) should be differentiated from chronic spontaneous urticaria (CSU) in patients initially presenting with recurrent wheals, although criteria for differential diagnosis remain ill-defined.