A5040566072- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Antibiotic Resistance in Bacteria
- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Occupational exposure and asthma
- Photosynthetic Processes and Mechanisms
- Microtubule and mitosis dynamics
- Bacterial Identification and Susceptibility Testing
- Eosinophilic Disorders and Syndromes
- Mast cells and histamine
- Autoimmune Bullous Skin Diseases
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Dermatological and COVID-19 studies
- Cutaneous lymphoproliferative disorders research
- Fungal and yeast genetics research
- Nail Diseases and Treatments
- Histiocytic Disorders and Treatments
- Phytochemicals and Medicinal Plants
- Infections and bacterial resistance
- Diphtheria, Corynebacterium, and Tetanus
University Hospital of Zurich
2017-2024
CK-CARE
2022-2024
University of Zurich
2019-2024
LEO Foundation
2024
University of Copenhagen
2024
Icahn School of Medicine at Mount Sinai
2021
Union Bank of Switzerland
2021
Max Planck Society
2018
Max Planck Institute for Social Anthropology
2018
Ludwig-Maximilians-Universität München
2011-2013
In the peripheral nervous system (PNS), damaged axons regenerate successfully, whereas in CNS fail to regrow. neurons of dorsal root ganglia (DRG), which extend branches both PNS and CNS, only a lesion but not induces axonal growth. How this differential growth response is regulated vivo incompletely understood. Here, we combine time-lapse fluorescence microscopy with genetic manipulations mice reveal how transcription factor STAT3 regulates regeneration. We show that selective deletion DRG...
The COVID-19 pandemic dramatically disrupts health care around the globe. impact of on chronic urticaria (CU) and its management are largely unknown.To understand how CU patients affected by pandemic; specialists alter patient management; course in with COVID-19.Our cross-sectional, international, questionnaire-based, multicenter UCARE COVID-CU study assessed consultations, remote treatment, changes medications, clinical consequences.The severely impairs care, less than 50% weekly numbers...
The common use of isothiazolinones as preservatives is a global cause allergic contact dermatitis. Differences in allowable concentrations methylisothiazolinone (MI) exist Europe, Canada, and the US.
ABSTRACT Corynebacterium tuberculostearicum is a lipophilic corynebacterium validly characterized in 2004. We provide clinical information on 18 patients from whom this organism was isolated. The majority of the were hospitalized and had history prolonged treatment with broad-spectrum antimicrobials. In 7 (38.9%) cases, isolates found to be clinically relevant. present report also includes detailed data biochemical molecular identification C. , as well its by matrix-assisted laser desorption...
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and driven by a complex pathophysiology underlying highly heterogeneous phenotypes. Current advances in precision medicine emphasize need for stratification.To perform deep phenotyping identification of severity-associated factors adolescent adult patients with AD.Cross-sectional data from baseline visit prospective longitudinal study investigating phenotype among inpatients outpatients AD Department Dermatology...
Atopic dermatitis (AD) has long been regarded as a primarily pediatric disease. However, there is growing evidence for high rate of adult-onset AD. We aimed to characterize factors associated with versus childhood-onset AD and controls.We analyzed cross-sectional data the CK-CARE-ProRaD cohorts Bonn, Augsburg, Davos, Zürich 736 adult patients stratified by age onset (childhood-onset <18 years: 76.4% (subsets: 0 2; ≥2 6; ≥7 11; ≥12 18); ≥18 23.6% 40; ≥41 60; ≥61) 167 controls (91 atopic, 76...
Intralymphatic immunotherapy (ILIT) represents a promising novel approach treating allergic diseases. However, no standardized procedures or recommendations have been established reported, despite the recognized fact that treatment efficacy relies on ability to inject allergen intranodally.
Coronavirus disease-2019 (COVID-19) has been associated with cutaneous findings, some being the result of drug hypersensitivity reactions such as maculopapular rashes (MDR). The aim this study was to investigate whether COVID-19 may impact development MDR.
Colistin is used against multi-drug resistant pathogens, yet resistance emerges through dissemination of plasmid-mediated genes (mcr) or chromosomal mutation involved in lipopolysaccharide synthesis (i.e. mgrB, phoPQ, pmrCAB). Phenotypic susceptibility testing challenging due to poor diffusion colistin agar media, leading an underestimation resistance. Performance five phenotypic approaches was compared the context different molecular mechanisms We evaluated Vitek 2® (bioMérieux, AST N242),...
Abstract Background Propolis types differ regarding their chemical composition. Objectives To compare patch test results based on Brazilian (Green) propolis with data Chinese (poplar‐type) propolis, and to evaluate the specifications of raw materials used for PT preparations. Methods In Information Network Departments Dermatology (IVDK), 1290 consecutive patients were tested (NH400, SmartPractice Europe). Patch reactivity was compared obtained (NA71, Europe) by calculating frequencies...
Background Injuries to the spinal cord often result in severe functional deficits that, case of incomplete injuries, can be partially compensated by axonal remodeling. The corticospinal tract (CST), for example, responds a thoracic transection with formation an intraspinal detour circuit. key step circuit is sprouting new CST collaterals cervical that contact local interneurons. How individual are formed and refined over time incompletely understood. Methodology/Principal Findings We traced...
Hair cosmetic products contain several, partly potent contact allergens, including excipients like preservatives. Hand dermatitis in hairdressers is common, scalp and face clients or self-users (summarised here as 'consumers') may be severe.To compare frequencies of sensitization to hair ingredients other selected allergens between female patch tested patients working consumers without professional background, respectively, who were for suspected allergic such products.Patch test clinical...
Concerns regarding contact allergies and intolerance reactions to dental materials are widespread among patients. Development of novel less frequent amalgam use may alter sensitization profiles in patients with possible allergy.
We investigated the migration of multiple nuclei in hyphae filamentous fungus Ashbya gossypii. Three types cytoplasmic microtubule (cMT)-dependent nuclear movements were characterized using live cell imaging: short-range oscillations (up to 4.5 microm/min), rotations 180 degrees 30 s), and long-range bypassing 9 microm/min). These superimposed on a cMT-independent mode migration, cotransport with stream. This latter is sufficient support wild-type-like hyphal growth speeds. cMT-dependent led...
Scope English walnut ( Juglans regia ) belongs to the most important allergenic tree nuts. Co‐sensitization with birch Betula verrucosa pollen has been reported. We aimed identify a allergen homologous major Bet v 1. Methods and results A cDNA encoding 1‐homologous (Jug r 5) in kernels was cloned by RT‐PCR. Jug 5 expressed Escherichia coli , purified column chromatography characterized circular dichroism spectroscopy. Specific IgE levels walnut, 1, allergics n = 16) concomitant allergy were...
Matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry (MS) is a widely used method for bacterial species identification. Incomplete databases and spectral quality (MSQ) still represent major challenges. Important proxies MSQ are the number detected marker masses, reproducibility, measurement precision. We aimed to assess MSQs across diagnostic laboratories potential simple workflow adaptations improve it.For baseline assessment, 47 diverse strains, which...
ABSTRACT During filamentous fungus development, multinucleated hyphae employ a system for long-range nuclear migration to maintain an equal density. A decade ago the microtubule motor dynein was shown play central role in this process. Previous studies with Ashbya gossypii revealed extensive bidirectional movements and bypassings of nuclei, autonomous cytoplasmic (cMT) cytoskeleton emanating from each nucleus, pulling nuclei by sliding cMTs along cortex. Here, we show that is sole bypassing...