A5011464111- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Microbial infections and disease research
- Pharmaceutical and Antibiotic Environmental Impacts
- Gut microbiota and health
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Clostridium difficile and Clostridium perfringens research
- Biochemical and Structural Characterization
- Antibiotic Use and Resistance
- Probiotics and Fermented Foods
- Veterinary Medicine and Surgery
- Mycobacterium research and diagnosis
- Escherichia coli research studies
- Streptococcal Infections and Treatments
- Veterinary Equine Medical Research
- Veterinary Pharmacology and Anesthesia
- Urinary Tract Infections Management
- Bacteriophages and microbial interactions
- Veterinary medicine and infectious diseases
- Nail Diseases and Treatments
- Animal Behavior and Welfare Studies
- Viral gastroenteritis research and epidemiology
University of Copenhagen
2016-2025
Ghent University Hospital
2024
European Society of Clinical Microbiology and Infectious Diseases
2024
Zoetis (United States)
2018
Danish Agriculture and Food Council
2013
The close contact between household pets and people offers favourable conditions for bacterial transmission. In this article, the aetiology, prevalence, transmission, impact on human health preventative measures are summarized selected zoonoses transmissible by pets. Six representing distinct transmission routes were arbitrarily based available information incidence severity of pet-associated disease caused zoonotic bacteria: bite infections cat scratch (physical injuries), psittacosis...
ABSTRACT Several lines of evidence indicate that the most primitive staphylococcal species, those Staphylococcus sciuri group, were involved in first stages evolution cassette chromosome mec (SCC ), genetic element carrying β-lactam resistance gene mecA . However, many steps are still missing from this evolutionary history. In particular, it is not known how was incorporated into mobile SCC prior to dissemination among aureus and other pathogenic species. To gain insights possible...
There is a growing concern regarding the increase of antimicrobial resistant bacteria in companion animals. Yet, there are no studies comparing resistance levels these organisms European countries. The aim this study was to investigate geographical and temporal trends causing urinary tract infection (UTI) animals Europe. susceptibility 22 256 isolated from dogs cats with UTI determined. Samples were collected between 2008 2013 16 laboratories 14 prevalence most common determined for each...
Staphylococci are associated with both humans and animals. While most non-pathogenic colonizers, Staphylococcus aureus is an opportunistic pathogen capable of causing severe infections. S. virulence controlled by the agr quorum sensing system responding to secreted auto-inducing peptides (AIPs) sensed AgrC, a two component histidine kinase. loci found also in other staphylococcal species for epidermidis, encoded AIP represses expression regulated genes aureus. In this study we aimed...
Antimicrobial resistance (AMR) should be tackled through a One Health approach, as stated in the World Organization Global Action Plan on AMR. We describe landscape of AMR surveillance European Union/European Economic Area (EU/EEA) and underline gap regarding veterinary medicine. Current efforts are limited help to practitioners policymakers seeking improve antimicrobial stewardship animal health. propose establish Resistance Surveillance network Veterinary medicine (EARS-Vet) report...
The monitoring of antimicrobial resistance (AMR) in bacterial pathogens animals is not currently coordinated at European level. To fill this gap, experts the Union Joint Action on Antimicrobial Resistance and Healthcare Associated Infections (EU-JAMRAI) recommended building Surveillance network Veterinary medicine (EARS-Vet). In study, we (i) identified national systems for AMR (both companion food-producing) among 27 countries affiliated to EU-JAMRAI, (ii) described their structures...
ABSTRACT Ampicillin resistance is a marker for hospital-associated Enterococcus faecium . Feces from 208 dogs were selectively screened the occurrence of ampicillin-resistant E. (AREF). AREF was detected in 42 (23%) 183 cross-sectional study United Kingdom and 19 (76%) 25 studied longitudinally Denmark. carriage intermittent all longitudinally. Multilocus sequence typing 63 canine isolates revealed presence 13 distinct types. Approximately 76% belonged to hospital-adapted clonal complex 17...
The epidemiologically most important mechanism of antibiotic resistance in Staphylococcus aureus is associated with mecA–an acquired gene encoding an extra penicillin-binding protein (PBP2a) low affinity to virtually all β-lactams. introduction mecA into the S. chromosome has led emergence methicillin-resistant (MRSA) pandemics, responsible for high rates mortality worldwide. Nonetheless, little known regarding origin and evolution mecA. Different homologues have been identified species...
Denmark is a country with high prevalence of livestock-associated methicillin-resistant Staphylococcus aureus (MRSA) clonal complex (CC) 398 in pigs. Even though pig farming regarded as the main source human infection or colonization MRSA CC398, 10-15% cases appear not to be linked Following recent reports CC398 horses other European countries and lack knowledge on S. carriage this animal species, we carried out study investigate whether constitute reservoir Denmark, gain frequency genetic...
Preterm infants are susceptible to infection and necrotizing enterocolitis (NEC) often treated with antibiotics. Simultaneous administration of enteral parenteral antibiotics during the first days after preterm birth prevents formula-induced NEC lesions in pigs, but it is unknown which route most effective. We hypothesized that only suppress gut bacterial colonization progression formula-fed pigs. Caesarean-delivered pigs (90-92% gestation) were fed increasing amounts infant formula from day...
Antimicrobial stewardship guidelines (ASGs) represent an important tool to help veterinarians optimize their antimicrobial use with the objective of decreasing resistance. The aim this study was map and qualitatively assess ASGs for in cats dogs Europe. Country representatives European Network Optimization Veterinary Treatment (ENOVAT) were asked identify published countries. All collated updated since January 2010 containing recommendations on therapy at least three conditions affecting...
ABSTRACT Campylobacter jejuni was recovered from four dogs (11%) and cats (33%) living with Danish human patients infected C. . Pulsed-field gel electrophoresis (PFGE) analysis revealed the occurrence of same quinolone-resistant strain in a girl her dog. isolates closely related (>95% similarity) PFGE profiles occurred humans pets different counties.
Background There is a lack of studies comparing topical antiseptics to systemic antibiotics in the treatment canine superficial pyoderma. Hypothesis/Objectives To compare efficacy chlorhexidine with amoxicillin–clavulanic acid for Animals A randomized controlled trial was conducted dogs Group T ( n = 31) treated topically 4% digluconate shampoo (twice weekly) and solution (once daily) 4 weeks. S 20) orally (25 mg/kg) twice daily Methods Bacterial culture susceptibility testing were performed...
Current knowledge on extended-spectrum beta-lactamases (ESBLs) in animals is based largely cross-sectional studies and qualitative data. The aim of this longitudinal study was to elucidate carriage proportions fecal counts ESBL-producing Escherichia coli pigs during the production cycle. At each three ESBL-positive single-sited farrow-to-finisher pig farms (farms A, B, C) included study, individual samples were taken from 17 20 sows 1 week before farrowing 2 piglets sow's litter four times...
This study provides an estimate of antimicrobial resistance in intestinal indicator bacteria from humans (n = 97) and food animals 388) Tanzania. More than 70% all fecal samples contained tetracycline (TE), sulfamethoxazole (STX), ampicillin (AMP)-resistant coliforms, while cefotaxime (CTX)-resistant coliforms were observed 40% samples. The average Log10 colony forming units/g CTX-resistant 2.20. Of 390 Escherichia coli tested, 66.4% resistant to TE, 54.9% STX, streptomycin, 36.4% CTX....
Interpretive criteria for antimicrobial susceptibility testing are lacking most antimicrobials used bovine streptococcal mastitis. The objectives of this study were to determine (tentative) epidemiological cut-off ((T)ECOFF) values clinically relevant antibiotics treatment mastitis, and estimate the proportion acquired resistance (non-wild-types) in Streptococcus dysgalactiae subsp. uberis. A total 255 S. uberis 231 isolates obtained Denmark Norway from tested 10 using broth microdilution....
Background Zoonotic transmission of livestock-associated methicillin-resistant Staphylococcus aureus clonal complex 398 (LA-MRSA CC398) from industrial pig farms to farm workers and their household members secondary elderly immunocompromised persons has led a growing number serious infections even death. Objective We tested the hypothesis that conventional confer higher risk for LA-MRSA CC398 carriage among than specific pathogen-free (SPF) farms, which follow set stringent rules concerning...
Abstract Objective To investigate the in vitro efficacy of antibiotics (amikacin, ceftiofur, and gentamicin) combination with local anesthetics (LAs; bupivacaine hydrochloride, lidocaine mepivacaine hydrochloride), a commonly performed for IA injectate regional limb perfusion (RLP) horses. Methods 17 equine clinical isolates were tested by checkerboard method their minimum inhibitory concentration (MIC) against concentrations LAs from August 2020 through December 2023. Results For majority...
Multidrug-resistant bacteria pose a serious threat to public health worldwide. Previously, α-peptide/β-peptoid hybrid oligomers were found display activity against Gram-negative multidrug-resistant bacteria. In the present work, influence of hydrophobicity, fluorination, and distribution cationic/hydrophobic residues on antimicrobial, hemolytic, cytotoxic properties hybrids investigated. An array 22 peptidomimetics was tested. Analogues with enhanced hydrophobicity exhibit increased...
The Danish antibiotic use guidelines for companion animal practice were published by the Veterinary Association in 2012. Since then, national surveillance data indicate a 10% reduction total of antibiotics animals, particularly marked third generation cephalosporins. aim study was to assess if and how have impacted diagnostic prescription habits users, identify user perceived barriers implementation. An online questionnaire sent all 882 members Small Animal October 2015. survey completed 151...