A5034539151- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Long-Term Effects of COVID-19
- Inflammasome and immune disorders
- Vitamin K Research Studies
- Mast cells and histamine
- Drug-Induced Adverse Reactions
- COVID-19 Clinical Research Studies
City Clinical Hospital
2020-2023
Moscow City Hospital No 29
2023
Scientific Research Institute of Healthcare Organization and Medical Management
2023
Regional Public Health Care Institution "City Hospital No. 5, Barnaul"
2020
State Hospital
2020
According to accumulated clinical data, one of the causes severe damage lung epithelial cells associated with SARS-CoV-2 (2019-nCoV) is an acute, timely underestimated "cytokine storm" (cytokine cascade, hypercytokinaemia) characteristic signs expressed hyper-inflammatory syndrome subsequent polyorganic failure. The study presents results analysis effectiveness tocilizumab therapy (TCZ) in patients (n = 181) different age groups developed pneumonia caused by SARS-CoV-2. aim was evaluate TCZ...
BACKGROUND: Cholinergic urticaria has affected 0.0211.2% of the population. Young adults are most frequently age group, and long-term duration disease is typical. Urticarial elements can often be generalized, systemic reactions present in patients with cholinergic urticaria, significantly reducing their quality life. At present, no clear predictors anaphylaxis a severe course have been identified.
 AIM: To evaluate clinical, laboratory, pathogenetic features identify correlations...
BACKGROUND: Сhronic spontaneous urticaria is characterized by itchy wheals and/or angioedema on the skin for ≥6 weeks. A large-scale international AWARE study Russian researchers indicated ineffectiveness of therapy with standard doses second-generation antihistamines in 50% patients chronic urticaria. Clinical predictors antihistamine resistance include low quality life based CU-Q2oL, baseline activity score 7 days (UAS7) 16, combination inducible urticaria, and autoimmune comorbidity....
BACKGROUND: Chronic inducible urticaria is a group of diseases that characterized by the development wheals, angioedema, or both in response to specific triggers for 6 weeks. According global scientific international literature, occurrence chronic 0.5% general population and approximately 20%30% all urticarias. The prevalence has no statistical data Russian Federation.
 AIM: This study aimed evaluate region-specific epidemiology different forms urticaria.
 MATERIALS AND METHODS:...
This article describes the clinical, biochemical and genetic features of hereditary angioedema (HAE) with normal level functional activity C1 esterase inhibitor. The discussion includes pathogenesis, diagnostics case management patients without inhibitor deficiency. materials few scientific sources about HAE deficiency in stages our own clinical (the female patient fertile age a confirmed mutation associated factor XII (Hageman) deficiency) was given. current state issue algorithm primary...
This article describes the clinical, biochemical and genetic features of hereditary angioedema (HAE) with normal level functional activity C1 esterase inhibitor. The discussion includes pathogenesis, diagnostics case management patients without inhibitor deficiency. materials few scientific sources about HAE deficiency in stages our own clinical (the female patient fertile age a confirmed mutation associated factor XII (Hageman) deficiency) was given. current state issue algorithm primary...
Atopic dermatitis (AD) is a multifactorial genetically determined immune-mediated skin disease. It difficult to treat and significantly affects patients quality of life. The development an integrated approach focusing on atopic multimorbidity, implementation validated control tools distinction clinical parameters specific for different phenotypes severe forms disease especially relevant resistant standard therapy techniques. Dupilumab, biologic, approved the treatment group with moderate AD...
Chronic-induced urticaria is a group of diseases characterized by the occurrence itchy wheals and/or angioedema in response to specific triggers, such as mechanical irritation, exposure high and low temperatures, vibration, ultraviolet radiation various spectra, appearing for 6 weeks. This long duration, significant effect on patients quality life, risk severe life-threatening reactions.
 The diagnosis induced patient-safe reproduction symptoms trigger (temperature, mechanical, etc.)....
Hereditary angioedema is a rare genetically determined disease characterized by the recurrent of various localizations with no response to systemic glucocorticosteroids, antihistamines.
 In majority hereditary cases C1-inhibitor level or its functional activity decreased due mutation in SERPING1 gene. recent years, expansion genetic diagnostic recourses significantly changed our understanding pathogenesis without deficiency previously unknown mutations. Currently mutations six different...
Hereditary angioedema (HAE) is a genetically caused orphan disease with high risk of developing life-threatening attacks, thus requiring availability for up-to-date information on this problem the doctors any specialties. A limited number observations determine value analysis each clinical case. Many facets manifestations, list predisposing and triggering factors, as well limitations some diagnostic therapeutic algorithms, require development individual management schemes under distinct...