A5069008401- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- DNA Repair Mechanisms
- Childhood Cancer Survivors' Quality of Life
- Polyomavirus and related diseases
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- CRISPR and Genetic Engineering
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Genomics and Chromatin Dynamics
- Immunodeficiency and Autoimmune Disorders
- Oral Health Pathology and Treatment
Belarusian Research Center For Pediatric Oncology and Hematology
2015-2021
Nijmegen breakage syndrome (NBS) is a DNA repair disorder characterized by combined immunodeficiency and high predisposition to lymphoid malignancies. The majority of NBS patients are identified with homozygous five base pair deletion in the Nibrin ( NBN) gene (c.657_661del5, p.K219fsX19) founder effect observed Caucasian European populations, especially Slavic origin. We present here an analysis cohort 136 Eastern Slav origin across Belarus, Ukraine, Russia, Latvia focus on understanding...
Minimal residual disease (MRD) appears to have a strong negative predictive value for recurrence in children with anaplastic large cell lymphoma (ALCL). Brentuximab vedotin (BV) can be therapeutic option MRD-positive patients achieve molecular remission and decrease risk of subsequent relapse. We here report 4-year-old child ALCL progression during relapse treatment who received BV as bridging therapy before haploidentical hematopoietic stem-cell transplantation, maintenance post-transplant...
Minimal residual disease (MRD) is an independent predictor of relapse risk for childhood acute lymphoblastic leukemia(ALL). The aim study to investigate impact MRD by real-time quantitative polymerase chain reaction before (day –21) andat +30 ± 10, +60 +100 +180 +365 10 days after hematopoietic stem cell transplantation (HSCT), and PCR-chimerismon transplant outcomes children with ALL. was approved the Independent Ethics Committee Scientific Councilof Belarusian Research Center Pediatric...
Allogeneic hematopoietic stem cell transplantation (HSCT) is a recognized method for treating children with very high risk group acute lymphoblastic leukemia (ALL) and myeloid (AML). The use of allogeneic HSCT certain groups significantly improves the survival these patients compared to chemotherapeutic regimens. aim this study was identify causes failure HSC in homogeneous possibility further improvement rates. approved by Independent Ethics Committee Scientific Council Belarusian Research...
More than 20–25 % of patients with acute leukemia underwent transplantation HSC from HLA-identical sibling or unrelated donor had relapse.Therefore, the purpose this study was to evaluate influence different factors on risk post-transplantation relapse in children and teenagers lymphoblastic (ALL).The gender, age a at time transplantation; recipient type, number relapses previous HSCTs; type conditioning; source stem cells; transplant parameters; (aGVHD) chronic (cGVHD) graft-versus-host...