A5041637732- Regulation of Appetite and Obesity
- Pregnancy-related medical research
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Eating Disorders and Behaviors
- Human Health and Disease
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Biochemical Analysis and Sensing Techniques
- Occupational Health and Performance
- HIV-related health complications and treatments
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Immune responses and vaccinations
- Immunodeficiency and Autoimmune Disorders
- Urticaria and Related Conditions
- Biochemical Acid Research Studies
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Neuroscience of respiration and sleep
- Virology and Viral Diseases
- Physical Education and Training Studies
- Tryptophan and brain disorders
- Cannabis and Cannabinoid Research
- Vestibular and auditory disorders
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2010-2021
Université Laval
2010-2021
Scientific Center of Family Health Problems and Human Reproduction
2013-2018
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2014-2018
City Clinical Hospital No15 named. O. M. Filatova
2018
Tomsk Polytechnic University
2016
Canadian Institutes of Health Research
2011
Hôpital du Saint-Sacrement
2008
Centre hospitalier de l'Université Laval
2004
This study investigated sex-specific effects of repeated stress and food restriction on intake, body weight, corticosterone plasma levels expression corticotropin-releasing factor (CRF) in the hypothalamus relaxin-3 nucleus incertus (NI). The CRF is affected by stress, these neuropeptides produce opposite feeding (anorexigenic orexigenic, respectively), but regulation chronic not fully understood. Male female rats were fed ad libitum chow (AC) or intermittent palatable liquid Ensure without...
The present study investigated the operational features of whisker-evoked EPSPs in barreloid cells and ability whisker-to-barreloid pathway to relay high rates whisker deflection lightly anesthetized rats. Results show that lemniscal are single-fiber events with fast rise times (<500 μsec) strongly depress at short inter-EPSP intervals. They occur latencies (3.84 ± 0.96 msec) little jitters (<300 after electrical stimulation follicle. Waveform analysis indicates one three axons...
Expression of CRF messenger RNA (mRNA) and heteronuclear (hnRNA) as well the mRNAs encoding receptors type 1 (CRF1R) 2 alpha (CFR2R) in brain has been investigated lean (Fa/?) obese (fa/fa) Zucker rats. Exonic intronic situ hybridization histochemistry was employed to measure mRNA hnRNA levels rats killed before (resting state), during, 120 min after a treadmill running session. The resting expression hypothalamic paraventricular nucleus (PVN) minimal comparable that However, during running,...
Trigeminal sensory nuclei are the first processing stage in vibrissal system of rodents. They feature separate populations thalamic projecting cells and a rich network intersubnuclear connections, so that what is conveyed to cortex by each ascending pathways information depends on local transactions occur brainstem. In present study, we examined nature these connections combining electrolytic lesions with electrophysiological recordings, retrograde labeling situ hybridization, anterograde...
The aim of our study was to investigate the anorectic and brain stimulatory effects various doses exendin-4 (Ex-4) role vagus nerve in Ex-4-induced activation. A dose-related increase c- fos mRNA expression observed following Ex-4 administration (0.155–15.5 μg/kg). Doses that caused anorexia without aversive (0.155, 0.775 μg/kg) induced hypothalamic arcuate paraventricular (PVH; parvocellular) nuclei as well limbic brainstem structures. aversion (1.55, 15.5 stimulated same regions (in a more...
The time course of the action food deprivation on functional activation corticotropin-releasing hormone (CRH) neurons and expression genes encoding CRH its receptors type 1 (CRH1-R) 2alpha (CRH2-R) in brain were assessed lean (Fa/?) obese (fa/fa) Zucker rats. Fa/? fa/fa rats assigned to periods 0, 3, 6, 12, 24 h. Measurements Fos immunoreactivity mRNA carried out same sections assess state neurons. In situ hybridization histochemistry was employed measure mRNAs receptors. rats, induced a...
Key points Relaxin‐3 is a stress‐responsive neuropeptide that acts at its cognate receptor, RXFP3, to alter behaviours including feeding. In this study, we have demonstrated direct, RXFP3‐dependent, inhibitory action of relaxin‐3 on oxytocin and vasopressin paraventricular nucleus (PVN) neuron electrical activity, putative cellular mechanism orexigenic actions relaxin‐3. We observed Gα i/o ‐protein‐dependent influence selective RXFP3 activation PVN neuronal activity in vitro direct neurons,...
This study was carried out to investigate the pattern of neuronal activations that occur in obese fa/fa Zucker rat during food deprivation. The functional activation neurons estimated lean and rats either fed ad libitum or food-deprived for 3, 6, 12, 24 hours by assessing expression immediate early gene c-fos. To identify instigating hypothalamic-pituitary-adrenal axis rats, retrograde tracer cholera toxin B subunit injected parvocellular division paraventricular hypothalamic nucleus...
The present study was conducted to investigate the effects of treadmill running on corticotropin-releasing hormone (CRH), CRH receptor type 1 (CRH-R1) and CRH-binding protein (CRH-BP) in brain rats that were killed either at rest, immediately after 60 min running, or 180 following a 60-min session intensive exercise. expression neuronal activity marker c-FOS also determined three conditions this study. levels mRNA high cortex, caudate-putamen, lateral septum, bed nucleus stria terminalis,...
This study compared the effects of relaxin-3 (RLN3) on food intake, plasma corticosterone, and expression corticotropin-releasing factor (CRF) in male female rats. RLN3 was injected into lateral ventricle at 25, 200, 800 pmol concentrations. 25 increased intake (grams) 30 60 minutes after injection but not Female rats also showed higher increase relative to body weight (BW) (mg/g BW) for all concentrations minutes. Moreover, significantly 24-hour BW gain At administration, produced a...
ABSTRACT Hippocampus is innervated by γ‐aminobutyric acid (GABA) “projection” neurons of the nucleus incertus (NI), including a population expressing neuropeptide, relaxin‐3 (RLN3). In studies aimed at gaining an understanding role RLN3 signaling in hippocampus via its G i/o ‐protein‐coupled receptor, RXFP3, we examined distribution RLN3‐immunoreactive nerve fibres and RXFP3 mRNA‐positive relation to hippocampal GABA neuron populations. RLN3‐positive elements were detected close‐apposition...
The present study was conducted to investigate the pattern of neuronal activation and corticotropin-releasing hormone (CRH) expression in fed, food deprived refed lean (Fa/?) obese (fa/fa) Zucker rats. studied by measuring immediate-early gene c-fos. Expression c-fos CRH mRNA determined situ hybridization histochemistry. In both rats, one hour refeeding led a transient increase levels which detected paraventricular hypothalamic nucleus (PVH), dorsomedial nucleus, supraoptic thalamic central...
This study addresses the origins of multiwhisker-receptive fields neurons in thalamic ventral posterior medial (VPM) nucleus rat. We sought to determine whether field synthesis occurs VPM through convergent projections from principalis (PrV) and interpolaris (SpVi) nuclei, or PrV by intersubnuclear spinal trigeminal complex. tested these hypotheses recording whisker-evoked responses before after electrolytic lesion SpVi lightly anesthetized rats. Before cells responded, on average, 3.2 +/-...
A double-labeling protocol was used to determine how cells with different angular preferences whisker motion distribute across the dimensions of a barreloid in ventral posterior medial nucleus rat thalamus. Individual barreloids were labeled retrogradely by injecting Fluoro-Gold identified barrel columns, and single relay ( n = 30) pertaining stained juxtacellularly Neurobiotin after determination their tuning preference controlled deflection. Results show that like are clustered within...