A5039234044- Multiple Sclerosis Research Studies
- Immune Response and Inflammation
- Coronary Artery Anomalies
- Cardiac tumors and thrombi
- Inflammasome and immune disorders
- Biomarkers in Disease Mechanisms
- Pediatric health and respiratory diseases
- Cardiac Structural Anomalies and Repair
- Neurological disorders and treatments
- Medical and Biological Sciences
- Neurological Disorders and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Microtubule and mitosis dynamics
- Neurogenesis and neuroplasticity mechanisms
- Systemic Sclerosis and Related Diseases
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
Omsk State Medical University
2011-2021
Multiple sclerosis (MS) is a serious, incurable neurological disease. In 2009, the ANZgene studies detected suggestive association of located upstream CD40 gene in chromosome 20q13 (p = 1.3×10−7). Identification causal variant(s) locus leads to better understanding mechanism underlying development autoimmune pathologies. We determined genotypes rs6074022, rs1883832, rs1535045, and rs11086996 patients with MS (n 1684) control group 879). Two SNPs were significantly associated MS: rs6074022...
Тhe article is devoted to one of the most common neurodegenerative diseases in world - Parkinson's disease (PD), prevalence which Russia reaches 140-150 people per 100 thousand people. The clinical and anamnestic profile a patient with PD presented, motor non-motor symptoms reflected, comparative characteristic neurological deficit Siberian population patients other cohorts presented. We studied 140 disease. A comprehensive assessment status was performed using “Unified Disease Rating Scale...
Myxoma of the heart is most common variant a primary benign tumor, which complicated in some cases by embolic complications. often diagnostic puzzle young patients due to low-symptom or masked clinical manifestations. This case report presents 37-year-old patient with onset left atrial myxoma mitral valve obstruction manifested syncope, associated traumatic brain injury, rightsided hemihypesthesia, and speech difficulties. The examination showed multiple lacunar ischemic lesions middle...
To study influence of polymorphic loci rs1800629 (TNFa), rs6074022 (CD40), rs187238 (IL-18), rs10492972 (KIF1B), rs4149584 (TNFRSF1A) on clinical features multiple sclerosis (MS) subject to sex belonging in Omsk city and region. Methods: neurological examination, molecular-genetic, statistic analyses. 265 patients with 576 healthy controls was observed. Results: observable don’t associated sex. In group men dysfunction the pyramidal, visual, pelvic functions course MS, women — pyramidal...