A5054423408- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Ultrasound and Hyperthermia Applications
- Ultrasound Imaging and Elastography
- Advanced MRI Techniques and Applications
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Systemic Sclerosis and Related Diseases
- Neurogenesis and neuroplasticity mechanisms
- Glioma Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Skin and Cellular Biology Research
- Rheumatoid Arthritis Research and Therapies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disorders and Treatments
- Effects of Vibration on Health
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Spinal Dysraphism and Malformations
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Extracellular vesicles in disease
- Cellular Mechanics and Interactions
- Vagus Nerve Stimulation Research
Amsterdam University Medical Centers
2019-2025
Vrije Universiteit Amsterdam
2019-2025
Amsterdam Neuroscience
2019-2025
Amsterdam UMC Location Vrije Universiteit Amsterdam
2007-2024
National Hospital for Neurology and Neurosurgery
2022
University College London
2022
Geneva College
2021
University Hospital of Geneva
2021
University Medical Center
2008-2009
<h3>Background:</h3> Different double inversion recovery (DIR) sequences are currently used in multiple sclerosis (MS) research centers to visualize cortical lesions, making it difficult compare published data. This study aimed formulate consensus recommendations for scoring lesions patients with MS, using DIR images acquired 6 European according local protocols. <h3>Methods:</h3> Consensus were formulated and tested a multinational meeting. <h3>Results:</h3> Cortical defined as focal...
Background Gray matter (GM) lesions are frequently found in multiple sclerosis (MS) and their in-vivo detection has been improved using new magnetic resonance imaging sequences, such as double inversion recovery (DIR). However, little is known about progression of GM over time. Objective To study the longitudinal behavior to explore relation cognitive impairment MS. Methods DIR images were acquired from 13 MS patients seven healthy controls at two time points with a median interval 3 years....
Tumor-educated platelets (TEPs) are potential biomarkers for cancer diagnostics. We employ TEP-derived RNA panels, determined by swarm intelligence, to detect and monitor glioblastoma. assessed specificity comparing the spliced profile of TEPs from glioblastoma patients with multiple sclerosis brain metastasis (validation series, n = 157; accuracy, 80%; AUC, 0.81 [95% CI, 0.74–0.89; p < 0.001]). Second, analysis versus asymptomatic healthy controls in an independent validation series (n 347)...
To describe signal and contrast properties of an isotropic, single-slab 3D dataset [double inversion-recovery (DIR), fluid-attenuated inversion recovery (FLAIR), T2, T1-weighted magnetization prepared rapid acquisition gradient-echo (MPRAGE)] to evaluate its performance in detecting multiple sclerosis (MS) brain lesions compared 2D T2-weighted spin-echo (T2SE). All sequences 2D-T2SE were acquired 16 MS patients 9 age-matched healthy controls. Lesions scored independently by two raters...
In this observational study, 159 patients with multiple sclerosis received personalized dosing of ocrelizumab incentivized by the COVID-19 pandemic. Re-dosing was scheduled when CD19 B-cell count ⩾10 cells/µL (starting 24 weeks after previous dose, repeated 4-weekly). Median interval until re-dosing or last 34 [30–38] weeks. No clinical relapses were reported and a minority showed Expanded Disability Status Scale (EDSS) progression. Monthly serum neurofilament light levels remained stable...
Background Cortical multiple sclerosis lesions are clinically relevant but inconspicuous at conventional clinical MRI. Double inversion recovery (DIR) and phase-sensitive (PSIR) more sensitive often unavailable. In the past 2 years, artificial intelligence (AI) was used to generate DIR PSIR from standard sequences (eg, T1-weighted, T2-weighted, fluid-attenuated inversion-recovery sequences), multicenter validation is crucial for further implementation. Purpose To evaluate cortical...
Abstract Purpose To investigate whether a recently improved version of the three‐dimensional double inversion‐recovery (3D‐DIR) technique enables in vivo detection hippocampal lesions multiple sclerosis (MS). Materials and Methods Magnetic resonance images 16 patients nine healthy control subjects were acquired at 1.5T. Lesions scored on 3D‐DIR anatomically classified as white matter (WM), cortical, or lesions. Associations between hippocampal, WM lesion numbers evaluated. Also,...
<h3>Objective</h3> To examine the predictive value of central atrophy in early multiple sclerosis (MS) patients, for medium term clinical outcome. <h3>Methods</h3> In 54 patients with recently diagnosed MS, and MRI parameters were obtained at baseline, after 2 5.5 years follow-up. addition to conventional annualised percentage brain volume change (aPBVC), ventricular (aPVVC) was quantified. Main outcome measure disease progression, defined by an increase Expanded Disability Status Scale ≥1...
Purpose To examine the benefits of using near-isotropic single-slab three-dimensional (3D) magnetic resonance (MR) imaging for creation subtraction images and to evaluate their performance in detection active multiple sclerosis (MS) brain lesions comparison with two-dimensional (2D) images. Materials Methods The study protocol was approved by local ethics review board all subjects gave written informed consent before investigation. Three-dimensional MR sequences, including double...
Background: Clinical measures in multiple sclerosis (MS) face limitations that may be overcome by utilising smartphone keyboard interactions acquired continuously and remotely during regular typing. Objective: The aim of this study was to determine the reliability validity keystroke dynamics assess clinical aspects MS. Methods: In total, 102 MS patients 24 controls were included observational study. Keyboard obtained with Neurokeys app. Eight timing-related features assessed for intraclass...
Cognitive impairment in people with MS (PwMS) has primarily been investigated using conventional imaging markers or fluid biomarkers of neurodegeneration separately. However, the single use these do only partially explain large heterogeneity found PwMS.To investigate multimodal (bio)markers: i.e., serum and cerebrospinal (CSF) levels neurofilament light chain (NfL) glial fibrillary acidic protein (GFAP) predicting cognitive functioning PwMS.Eighty-two PwMS (56 females, disease duration = 14...
Extended interval dosing (EID) of natalizumab is a promising strategy to optimise treatment in multiple sclerosis (MS). Personalised EID by therapeutic drug monitoring can enable further extension intervals.
To explore the applicability of subtraction magnetic resonance (MR) images to (a) detect active multiple sclerosis (MS) lesions, (b) directly quantify lesion load change, and (c) treatment effects (distinguish arms) in a placebo-controlled multicenter clinical trial by comparing scheme with conventional pair-wise comparison nonregistered MR images.Forty-six pairs studies 40 patients (31 women; mean age, 31.9 years) from were used. The was approved local ethics review boards, all subjects...
The objective of the study was to determine whether early infratentorial and/or spinal cord lesions are long-term cumulative predictors disability progression in multiple sclerosis (MS).We selected 153 MS patients from longitudinal Amsterdam cohort. Lesion analysis performed at baseline and year 2. Disability after 6 11 years measured using Expanded Status Scale (EDSS) EDSS-plus (including 25-foot walk 9-hole peg test). Patients with or were compared for risk 6- 11-year without lesions,...
<h3>Background and Objectives</h3> To investigate the potential of serum neurofilament light (NfL) to reflect or predict progression mostly independent acute inflammatory disease activity in patients with relapsing-remitting multiple sclerosis (RRMS) treated natalizumab. <h3>Methods</h3> Patients were selected from a prospective observational cohort study initiated 2006 at VU University Medical Center Amsterdam, Netherlands, including RRMS Selection criteria included an age 18 years older...
Abstract Objectives Quantitative radiological reports (QReports) can enhance clinical management of multiple sclerosis (MS) by including quantitative data from MRI scans. However, the lack consensus on specific information to include, and clinicians’ preferences, hinders adoption these imaging analysis tools. This study aims facilitate implementation QReports determining requirements regarding their use in MS management. Materials methods A four-phase Delphi panel approach was employed,...
Brain atrophy is relevant for understanding disease progression and treatment response in people with multiple sclerosis (pwMS). Automatic brain volume-reporting tools often rely on healthy control (HC) reference curves to interpret volumes, whereas volume loss different pwMS. This observational study aimed develop an MS-specific model volumes evaluate its performance compared HC-based curves, as a proof-of-concept. Participants, pwMS HCs, from the Amsterdam MS cohort were included based...
Abstract Objective To compare long‐interval T2‐weighted subtraction (T2w‐Sub) imaging with monthly gadolinium‐enhanced T1‐weighted (Gd‐T1w) for (1) detection of active lesions, (2) assessment treatment efficacy, and (3) statistical power, in a multiple sclerosis (MS), phase 2, clinical trial setting. Methods Magnetic resonance (MRI) data over 9 months from 120 patients (61 treatment, 59 placebo) the oral temsirolimus were used. T2w‐Sub images scored independent original reading Gd‐T1w...
Background: Natalizumab treatment provides a model for non-inflammation-induced disease progression in multiple sclerosis (MS). Objective: To study serum contactin-1 (sCNTN1) as novel biomarker natalizumab-treated relapsing-remitting MS (RRMS) patients. Methods: Eighty-nine RRMS patients with minimum follow-up of 3 years were included. sCNTN1 was analyzed at baseline (before natalizumab initiation), 3, 12, 24 months (M) and last (median 5.2 years) compared to 222 healthy controls (HC) 15...
Automatic lesion segmentation techniques on MRI scans of people with multiple sclerosis (pwMS) could support detection and in trials clinical practice. However, knowledge their reliability across scanners is limited, hampering implementation. The aim this study was to investigate the within-scanner repeatability between-scanner reproducibility tools pwMS three different examine accuracy compared manual segmentations without optimization.
Background and objectives: Serum neurofilament light (sNfL) is a biomarker for neuro-axonal damage in multiple sclerosis (MS). Clinical implementation remains limited. We investigated the impact of on clinical decisions using questionnaires at MS Center Amsterdam, tertiary outpatient clinic. Methods: sNfL assessments were added to routine practice (August 2021–December 2022). Before after results, clinicians filled context testing, decisions, certainty herein, expectation magnetic resonance...
Importance Increasing numbers of people with multiple sclerosis (MS) use disease-modifying therapy (DMT). Long-term stable disease while taking such medications provides a rationale for considering DMT discontinuation given patient burden, costs, and potential adverse effects immunomodulating therapy. Objective To investigate whether first-line can be safely discontinued in patients long-term MS. Design, Setting, Participants This multicenter, rater-blinded, noninferiority randomized...
<h3>Background</h3> Several studies have confirmed the predictive value of baseline and follow-up magnetic resonance (MR) imaging variables for conversion to clinically definite multiple sclerosis (CDMS), depending on population, duration, treatment intervention. However, timing effect intervention MR require further elucidation. <h3>Objectives</h3> To assess prognostic CDMS over 3 years whether this was affected by (2) increased risk posed dissemination in time imaging. <h3>Design</h3>...