A5054878443- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Medical Image Segmentation Techniques
- Gene expression and cancer classification
- Tissue Engineering and Regenerative Medicine
- Down syndrome and intellectual disability research
- Adrenal Hormones and Disorders
- Thyroid and Parathyroid Surgery
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Exercise and Physiological Responses
- Congenital Heart Disease Studies
- Cell Image Analysis Techniques
- Advanced MRI Techniques and Applications
- Estrogen and related hormone effects
- Macrophage Migration Inhibitory Factor
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Stress Responses and Cortisol
- Nuclear Receptors and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Congenital heart defects research
- Renal and related cancers
- Inflammatory mediators and NSAID effects
- Mycobacterium research and diagnosis
University College London
2014-2020
Institute for Behavioral Medicine
2012-2017
The Ohio State University Wexner Medical Center
2015-2017
The Ohio State University
2007-2009
Multi-atlas segmentation propagation has evolved quickly in recent years, becoming a state-of-the-art methodology for automatic parcellation of structural images. However, few studies have applied these methods to preclinical research. In this study, we present fully framework mouse brain MRI using multi-atlas propagation. The adopts the similarity and truth estimation propagated segmentations (STEPS) algorithm, which utilises locally normalised cross correlation metric atlas selection an...
Alzheimer's disease is connected to a number of other neurodegenerative conditions, known collectively as 'tauopathies', by the presence aggregated tau protein in brain. Neuroinflammation and oxidative stress AD are associated with pathology both breakdown axonal sheaths white matter tracts excess iron accumulation grey brain regions. Despite identification myelin concentration major sources contrast quantitative susceptibility maps brain, sensitivity this technique has yet be explored. In...
With increasingly large numbers of mouse models human disease dedicated to MRI studies, compromises between in vivo and ex must be fully understood order inform the choice imaging methodology. We investigate application high resolution MRI, combination with tensor-based morphometry (TBM), uncover morphological differences rTg4510 model tauopathy. The also offers a novel paradigm by which overexpression mutant tau can regulated administration doxycycline, providing us platform on more subtle...
Mouse models of Alzheimer's disease have served as valuable tools for investigating pathogenic mechanisms relating to neurodegeneration, including tau-mediated and neurofibrillary tangle pathology—a major hallmark the disease. In this work, we used multiparametric magnetic resonance imaging (MRI) in a longitudinal study neurodegeneration rTg4510 mouse model tauopathy, subset which were treated with doxycycline at different time points suppress tau transgene. Using paradigm, investigated...
Brain volume measurements extracted from structural MRI data sets are a widely accepted neuroimaging biomarker to study mouse models of neurodegeneration. Whether acquire and analyze in vivo or ex is crucial decision during the phase experimental designs, as well analysis. In this work, we brain structures for both longitudinal single-time-point acquired same animals using accurate automatic multi-atlas parcellation, compared corresponding statistical classification We found that most gray...
We describe a fully automated pipeline for the morphometric phenotyping of mouse brains from μMRI data, and show its application to Tc1 model Down syndrome, identify new morphological phenotypes in brain this first transchromosomic animal carrying human chromosome 21. incorporate an accessible approach simultaneously scanning multiple ex vivo brains, requiring only 3D-printed holder, novel image processing steps their separation orientation. employ clinically established multi-atlas...
Background: Non-invasive characterization of the pathological features Alzheimer's disease (AD) could enhance patient management and development therapeutic strategies. Magnetic resonance imaging texture analysis (MRTA) has been used previously to extract descriptors from structural clinical scans in AD determine cerebral tissue heterogeneity. In this study, we examined potential MRTA specifically identify tau pathology an mouse model compared metrics histological measures burden. Methods:...
Down Syndrome is a chromosomal disorder that affects the development of cerebellar cortical lobules. Impaired neurogenesis in cerebellum varies among different types neuronal cells and layers. In this study, we developed an imaging analysis framework utilizes gadolinium-enhanced ex vivo mouse brain MRI. We extracted middle Purkinje layer cortex, enabling estimation volume, thickness, surface area entire internal granular layer, molecular Tc1 model Syndrome. The morphometric our method...
<h3>Background</h3> Studies have shown that stress and exercise elicit opposing immuno-modulatory effects. In concordance, we previously demonstrated daily, moderate systemically suppresses inflammatory responses by inhibiting NFκB in an acute model of inflammation. Conversely, also repeated social stimulates proinflammatory immune cell egress trafficking, which would exacerbate autoimmunity. Chronic levels inflammation are the hallmark autoimmune disease ever-present, contributing factors...
Abstract Multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS), is more prevalent in women than men. Recent studies suggest that cytokine migration inhibitory factor (MIF) plays a role progression MS and experimental encephalomyelitis (EAE). We have shown MIF−/− mice decreased EAE severity relative to wt controls. Here, we evaluate MIF context known suppressive hormones. Serum levels corticosterone (CORT) testosterone (TEST) were measured prior following...
Abstract Phosphoinositide 3-kinases (PI3K) are intracellular signaling proteins involved in cellular responses such as chemotaxis, proliferation and apoptosis. Selective inhibitors of the PI3Kγ-isoform have recently become available. This study explores role PI3Kγ development progression EAE. +/+ (wt) −/− (ko) mice were immunized for EAE using myelin oligodendrocyte glycoprotein p35-55 (MOG) assessed clinical signs, CNS histopathology T cell activation. WT showed a progressive disease course...
<h3>Background</h3> Despite numerous studies indicating the positive effects of exercise and psychological stress reduction in patients with autoimmune disease, these therapeutic modalities are currently underemphasized due to absence comprehensive immunological characterization regimen standardization. <h3>Objectives</h3> In order examine influence on immune system at cellular tissue level, disease pathology was analyzed NZM2410 mouse model lupus nephritis. To translate results begin...