A5031524161- Fetal and Pediatric Neurological Disorders
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Prenatal Screening and Diagnostics
- Advanced MRI Techniques and Applications
- Congenital Heart Disease Studies
- Advanced Neuroimaging Techniques and Applications
- Neonatal Respiratory Health Research
- Domain Adaptation and Few-Shot Learning
- Congenital Anomalies and Fetal Surgery
- MRI in cancer diagnosis
- Atomic and Subatomic Physics Research
- Infant Development and Preterm Care
- Preterm Birth and Chorioamnionitis
- Functional Brain Connectivity Studies
- Ultrasound in Clinical Applications
- Tracheal and airway disorders
- Epilepsy research and treatment
- Congenital heart defects research
- Anatomy and Medical Technology
- Glioma Diagnosis and Treatment
- Orthopedic Infections and Treatments
- Aortic Disease and Treatment Approaches
- Superconducting Materials and Applications
- Pediatric Urology and Nephrology Studies
King's College London
2020-2024
Guy's and St Thomas' NHS Foundation Trust
2023-2024
St Thomas' Hospital
2023-2024
St. Thomas Hospital
2023
Evelina London Children's Healthcare
2022-2023
University College London
2022
University College Hospital
2022
Children's National
2008-2019
Pennsylvania Hospital
2008
University of Michigan
2008
The dynamic nature and complexity of the cellular events that take place during last trimester pregnancy make developing cortex particularly vulnerable to perturbations. Abrupt interruption normal gestation can lead significant deviations many these processes, resulting in atypical trajectory cortical maturation preterm birth survivors. We sought first map typical micro- macrostructure development using invivo MRI a large sample healthy term-born infants scanned after (n = 259). Then we...
Background The benefits of using low-field-strength fetal MRI to evaluate antenatal development include reduced image artifacts, increased comfort, larger bore size, and potentially costs, but studies about are lacking. Purpose To the reliability feasibility assess anatomic functional measures in pregnant participants a commercially available 0.55-T scanner comprehensive 20-minute protocol. Materials Methods This prospective study was performed at large teaching hospital (St Thomas'...
Congenital heart disease (CHD) is common and associated with impaired early brain development neurodevelopmental outcomes, yet the exact mechanisms underlying these associations are unclear.
ObjectivesTo assess the relationships between (1) environmental and demographic factors executive function (EF) in preschool children with congenital heart disease (CHD) controls (2) clinical surgical risk EF CHD.Study DesignAt 4-6 years of age, parents CHD (n=51) (n=124) completed BRIEF-P questionnaire Cognitively Stimulating Parenting Scale (CSPS). Multivariable general linear modelling assessed relationship composite scores (Inhibitory Self-Control Index [ISCI], Flexibility [FI], Emergent...
The diverse cerebral consequences of preterm birth create significant challenges for understanding pathogenesis or predicting later outcome. Instead focusing on describing effects common to the group, comparing individual infants against robust normative data offers a powerful alternative study brain maturation. Here we used Gaussian process regression curves characterizing volumetric development in 274 term-born infants, modeling age at scan and sex. We then compared 89 scanned...
Infants with congenital heart disease are at risk of neurodevelopmental impairments, the origins which currently unclear. This study aimed to characterize relationship between neonatal brain development, cerebral oxygen delivery and outcome in infants disease. A cohort serious or critical (
Purpose Studying placental development informs when is abnormal. Most MRI studies are cross‐sectional and do not study the extent of individual variability throughout pregnancy. We aimed to explore how diffusion measures function microstructure vary in healthy pregnancies gestation. Methods Seventy‐nine pregnant, low‐risk participants (17 scanned twice 62 once) were included. T 2 ‐weighted anatomical imaging a combined multi‐echo spin‐echo diffusion‐weighted sequence acquired at 3 T....
Introduction Ultra-high field MR imaging offers marked gains in signal-to-noise ratio, spatial resolution, and contrast which translate to improved pathological anatomical sensitivity. These benefits are particularly relevant for the neonatal brain is rapidly developing sensitive injury. However, experience of neonates at 7T has been limited due regulatory, safety, practical considerations. We aimed establish a program safely acquiring high resolution images from on system. Methods Images...
Abstract This study explores the potential of 3D Slice-to-Volume Registration (SVR) motion-corrected fetal MRI for craniofacial assessment, traditionally used only brain analysis. In addition, we present first description an automated pipeline based on Attention UNet trained segmentation, followed by surface refinement. Results printing selected models are also presented. Qualitative analysis multiplanar volumes, SVR output and segmentations outputs, were assessed with computer printed...
To calculate 3D-segmented total lung volume (TLV) in fetuses with thoracic anomalies using deformable slice-to-volume registration (DSVR) comparison to 2D-manual segmentation. establish a normogram of TLV calculated by DSVR healthy control fetuses. A pilot study at single regional fetal medicine referral centre included 16 magnetic resonance imaging (MRI) datasets (22-32 weeks gestational age). Diagnosis was CDH (n = 6), CPAM 2), and controls 8). Deformable used for reconstruction 3D...
Abstract Structural fetal body MRI provides true 3D information required for volumetry of organs. However, current clinical and research practice primarily relies on manual slice-wise segmentation raw T2-weighted stacks, which is time consuming, subject to inter- intra-observer bias affected by motion-corruption. Furthermore, there are no existing standard guidelines defining a universal approach parcellation This work produces the first protocol organs motion-corrected MRI. It includes 10...
Abstract Introduction Infection and inflammation have been implicated in the etiology subsequent morbidity associated with preterm birth. At present, there are no tests to assess for fetal compartment infection. The thymus, a gland integral immune system, has shown involute animal models of antenatal infection, but its response human fetuses not studied. This study aims: (a) generate magnetic resonance imaging (MRI) ‐derived thymus volumes standardized weight; (b) compare from that delivered...
Background Infants with congenital heart disease (CHD) are at risk of neurodevelopmental impairments, which may be associated impaired brain growth. We characterized how perioperative growth in infants CHD deviates from typical trajectories and assessed the relationship between individualized clinical factors. Methods Results A total 36 underwent preoperative postoperative magnetic resonance imaging. Regional volumes were extracted. Normative volumetric development curves generated using...
Visual assessment of the placenta in antenatal magnetic resonance imaging is important to confirm healthy appearances or identify pathology complicating fetal anomaly maternal disease.We assessed a large cohort 228 women with low and high risk pregnancies across gestation. All gave written informed consent were imaged using either 3T Philips Achieva 1.5T Ingenia scanner. Images acquired T2-weighted single shot turbo spin echo sequence whole uterus (thereby including placenta) for anatomical...
Abstract Background Altered structural brain development has been identified in fetuses with Congenital Heart Disease (CHD), suggesting that the neurodevelopmental impairment observed later life might originate utero. There are many interacting factors may perturb neurodevelopment during fetal period and manifest as alterations, such altered cerebral substrate delivery aberrant hemodynamics. Methods We extracted covariance networks (SCNs) from log Jacobian determinants of 429 utero T2w MRI...
BACKGROUND AND PURPOSE: Head motion causes image degradation in brain MR imaging examinations, negatively impacting quality, especially pediatric populations. Here, we used a retrospective correction technique children and assessed quality improvement for 3D acquisitions. MATERIALS METHODS: We prospectively acquired at 3T using sequences, T1-weighted MPRAGE, T2-weighted TSE, FLAIR 32 unsedated children, including 7 with epilepsy (age range, 2–18 years). implemented novel through modification...
Children with Congenital Heart Disease (CHD) are at increased risk of neurodevelopmental impairments. The neonatal antecedents impaired behavioural development unknown. 43 infants CHD underwent presurgical brain diffusion-weighted MRI [postmenstrual age scan median (IQR) = 39.29 (38.71–39.71) weeks] and a follow-up assessment 22.1 (IQR 22.0–22.7) months in which parents reported internalizing externalizing problem scores on the Child Behaviour Checklist. We constructed structural networks...
The fetal thymus gland has been shown to involute in response intrauterine infection, and therefore could be used as a non-invasive marker of compartment infection. objective this study was evaluate how accurately 2D ultrasound-derived measurements the reflect 3D volume derived from motion corrected MRI images.A retrospective performed using paired ultrasound datasets iFIND project (http://www.ifindproject.com). To obtain volumetry gland, T2-weighted single shot turbo spin echo (ssTSE)...