Silicosis is a fatal occupational lung disease which currently has no effective treatment. Dihydroquercetin (DHQ) flavonoid compound known for its anti-inflammatory, anti-oxidant and anti-cancer bioactivity. However, whether DHQ protects against silica-induced fibrosis remains unknown. Therefore, we aimed to investigate the effect of on underlying molecular mechanism in vivo vitro . Our results demonstrated that treatment markedly attenuated SiO 2 -induced inflammation degree tissues C57BL/6...

Triptolide, a compound extracted from the traditional Chinese medicine preparation of Tripterygium wilfordii Hook F., has been reported to have anti-inflammatory and anti-cancer activities. However, its effect on ovarian cancer invasion is unknown. We observed that MMP7 MMP19 expression increased in tissue. Triptolide treatment inhibited migration cells SKOV3 A2780 at concentration 15 nM. also triptolide suppressed promoter activity dose-dependent manner, down-regulating expressions these...

Non‑small cell lung cancer (NSCLC) exhibits a high incidence and mortality rate worldwide. Elevated cytokinesis cyclin 25 homologous protein C (CDC25C) expression is correlated with poor prognosis in patients NSCLC. Transcriptional regulation post‑transcriptional modification are critical mechanisms governing gene expression, aberrations these processes increasingly recognized as pivotal contributors to pathogenesis. The present study elucidated that the transcriptional activator, signal...

Introduction Tumor-infiltrating B lymphocytes (TILBs) play a pivotal role in shaping the immune microenvironment of tumors (TIME) and progression lung adenocarcinoma (LUAD). However, there remains scarcity research that has thoroughly systematically delineated characteristics TILBs LUAD. Method The employed single-cell RNA sequencing from GSE117570 dataset to identify markers linked TILBs. A comprehensive machine learning approach, utilizing ten distinct algorithms, facilitated creation...

Closed reduction and percutaneous pin fixation is the recommended treatment of displaced supracondylar humerus fractures. The optimal configurations in fractures with coronal lateral obliquity remain controversial. aim this study was to compare stability various oblique provide an acceptable placement.Nine third-generation synthetic composite humeri were osteotomized simulate a humeral fracture obliquity. Each reduced fixed using 2 or three 1.6-mm (0.062 in) Kirschner wires (K-wire) 3...

Abstract As the persistent resistance of Staphylococcus aureus to available antibiotics is associated with high infection incidence, mortality rate and treatment cost, novel antibacterial agents innovative therapeutic targets must be developed. 3,3′-(4-Nitrobenzylidene)-bis-(4-hydroxycoumarin) (NBH), a dicoumarin derivative, was reported exert activity. This study investigated underlying mechanisms in vivo vitro activities NBH against S. . exerted bactericidal effects tested epidermidis...

Clear cell renal carcinoma (ccRCC) is a common type of fatal malignancy in the urinary system. As therapeutic strategies ccRCC are severely limited at present, prognosis patients with metastatic usually not promising. Revealing pathogenesis and identifying hub candidate genes for prediction precise treatment urgently needed ccRCC.In present study, we conducted series bioinformatics studies gene expression profiles samples from Gene Expression Omnibus (GEO) cancer genome atlas (TCGA) database...

Background: Immunoglobulin A nephropathy (IgAN) is the most common type of primary glomerulonephritis worldwide and a frequent cause end-stage renal disease. The inflammation cascade due to infiltration activation immune cells in glomeruli plays an essential role progression IgAN. In this study, we aimed identify hub genes involved explore potential prognostic biomarkers therapeutic targets Methods: We combined single-cell bulk transcriptome profiles IgAN patients controls with clinical...

Background. The majority of lung cancers are adenocarcinomas, with the proportion being 40%. patients mostly diagnosed in middle and late stages metastasis easy recurrence, which poses great challenge to treatment prognosis. Platinum-based chemotherapy is a primary for adenocarcinoma, frequently causes drug resistance. As result, it important uncover mechanisms chemoresponse adenocarcinoma platinum-based chemotherapy. Methods. genes from dataset GSE7880 were gathered into gene modules...

Percutaneous nephrolithotomy (PCNL) is an effective and well accepted procedure for the treatment of large complex renal calculi. We encountered a patient with misplaced percutaneous nephrostomy drainage tube (PNDT) into contralateral vein resulting thrombus formation after undergoing right side PCNL. placed temporary filter to prevent embolism started anti-coagulation therapy immediately finally PNDT was removed without bleeding.

Background: Surgery combined with chemotherapy (CT) is the best treatment for tumor patients at stage I to IIIA. But there are only few studies specifically evaluated survival benefits of removing different number regional lymph nodes (RLNs) IIA non-small cell lung cancer (NSCLC). The objective this study discuss effect RLNs on outcomes in operable NSCLC. Methods: Through use Surveillance, Epidemiology, and End Results (SEER) registry, satisfactory NSCLC, who had complete clinical...

N6-methyladenosine (m6A) is the most abundant internal modification on eukaryotic mRNAs. There increasing evidence that m6A plays a key role in tumor progression, so it important to analyze modifications within transcriptome-wide lung adenocarcinoma (LUAD). Three pairs of LUAD samples and tumor-adjacent normal tissues were obtained from South University Science Technology Hospital. And then methylated RNA immunoprecipitation sequencing (MeRIP-seq) (RNA-seq) used identify differential between...

Breast cancer (BC) is the second leading cause of tumor-related mortality after lung cancer. Chemotherapy resistance remains a major challenge to progress in BC treatment, warranting further exploration feasible and effective alternative therapies.

Background: Regional lymph nodes (RLNs) removed combined with surgery is a standard option for patients at stage I to IIIA NSCLC. The objective of the study clarify effect removing different number RLNs on survival outcomes N0 Methods: Patients NSCLC from 2004 2015 were identified Surveillance, Epidemiology, and End Results (SEER) database. Prior propensity score method (PSM), time was compared among (0, 1-3 ≥4) groups. After PSM, lung cancer-specific (LCSS) overall (OS) compared....

Abstract Background Breast cancer (BC) is one of the most common malignancies in women all over world. For patients with human epidermal growth factor receptor 2 positive (Her2+) BC, although widespread use anti-Her2 therapy has make for survival increased, improved led to an increased demand better management and diminish toxic side effects anticancer treatments. This study aimed identify potential biomarkers associated Her2 + BC order improve overall treatment. Results Our research...

目的: 探讨儿童掌指关节脱位的损伤机制及最佳治疗途径.方法: 1983～1995年收治新鲜掌指关节脱位8例、陈旧掌指关节脱位3例.11例患儿均为背侧脱位, 食指8例、拇指2例、中环小指同时脱位1例.闭合整复成功1例, 余者均予切开复位.术中见掌骨头自关节囊掌侧薄弱部穿出形成脱位; 掌板嵌顿在掌骨头背侧, 掌骨头掌面被掌浅横韧带卡住, 阻碍复位.结果: 新鲜掌指关节脱位8例, 治疗效果好; 陈旧掌指关节脱位3例, 即便切开复位, 仍遗留掌指关节活动明显受限, 1例甚至僵直.结论: 强调一旦闭合复位失败, 应及早手术解剖复位.

In the past decades, lung cancer is considered one of lethal cancers all across world due to its evidenced greatest mortality and morbidity. Currently, main clinical treatment methods for involve surgery, chemotherapy, radiotherapy, anti-angiogenesis inhibitors tyrosine kinase inhibitors. field anticancer drugs, a variety new drugs have been emerging in recent years. They include chemotherapy with delivery modes, targeted inhibitors, angiogenesis immunotherapy that remained hot. But because...