A5023626898- RNA modifications and cancer
- Urinary Bladder and Prostate Research
- Healthcare and Venom Research
- MicroRNA in disease regulation
- Traditional Chinese Medicine Studies
- Acupuncture Treatment Research Studies
- Circular RNAs in diseases
- Cancer-related gene regulation
- Venomous Animal Envenomation and Studies
- Lipid metabolism and disorders
- Phytochemistry and Bioactive Compounds
- Catalytic Alkyne Reactions
- Plant Stress Responses and Tolerance
- Sexual function and dysfunction studies
- Environmental and Biological Research in Conflict Zones
- Peptidase Inhibition and Analysis
- Natural product bioactivities and synthesis
- Microbial metabolism and enzyme function
- HVDC Systems and Fault Protection
- Cancer, Hypoxia, and Metabolism
- Rabies epidemiology and control
- Protein Tyrosine Phosphatases
- Ferroptosis and cancer prognosis
- Phytoestrogen effects and research
- Autophagy in Disease and Therapy
Southern University of Science and Technology
2021-2025
Southeast University
2025
Fanjingshan National Nature Reserve
2023
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine
2019-2022
Zhuhai People's Hospital
2022
Jiangxi University of Traditional Chinese Medicine
2022
Guangzhou University of Chinese Medicine
2019-2020
The microwave chemical looping synergistic gasification characteristics of municipal solid waste polypropylene plastic and the organic water hyacinth are experimentally investigated in this study. In addition, characterizations oxygen carriers before after reaction combined to analyze evolution microscopic morphology changes relative contents each valence state Fe O elements. results show that an increase mixing ratio presents positive effects on tar cracking a slight negative effect syngas...
Non‑small cell lung cancer (NSCLC) exhibits a high incidence and mortality rate worldwide. Elevated cytokinesis cyclin 25 homologous protein C (CDC25C) expression is correlated with poor prognosis in patients NSCLC. Transcriptional regulation post‑transcriptional modification are critical mechanisms governing gene expression, aberrations these processes increasingly recognized as pivotal contributors to pathogenesis. The present study elucidated that the transcriptional activator, signal...
Tumor angiogenesis is an important cause of tumor growth and metastasis. Myricetin a flavonoid component used in traditional Chinese medicine that has been demonstrated to have anticancer activity. However, the best our knowledge, effect myricetin on remains unknown. The present study reports identification as potential chemopreventive agent by reason its inhibition demonstrates effects vivo. Cell Counting Kit-8 assays revealed inhibits proliferation cells but not human umbilical vein...
The main mechanistic function of most chemotherapeutic drugs is mediated by inducing mitochondria-dependent apoptosis. Tumor cells usually respond to upregulate autophagy eliminate impaired mitochondria for survival. Hypothetically, inhibiting might promote apoptosis, thus enhancing the efficacy therapies. We previously identified N-methylparoxetine (NMP) as an inducer mitochondrial fragmentation with subsequent apoptosis in non-small cell lung cancer (NSCLC) cells. discovered that ROS was...
Dioscin, a natural glycoside derived from many plants, has been proved to exert anti-cancer activity. Several studies have found that it reverses TGF-β1-induced epithelial-mesenchymal transition (EMT). Whether dioscin can reverse EMT by pathways other than TGF-β is still unknown.We used network-based pharmacological methods systematically explore the potential mechanisms which acts on lung cancer. Cell Counting Kit-8 assay, scratch healing, Transwell Matrigel invasion immunofluorescence and...
Chronic non-bacterial prostatitis (CNBP) accounts for more than 90 % of clinical cases, and there is no specific effective treatment CNBP. The regulatory role Jiedu Huoxue decoction (JDHXD)in CNBP remains unclear. We investigated if JDHXD could improve METHODS: animal model was established by carrageenan injection with 1 (50 μL). prostate index, epithelial thickness, lumen area, pain response time were investigated. apoptosis levels measured TUNEL staining flow cytometry, respectively....
In this study, we aimed to investigate the role of miR-877-5p in malignant phenotypes prostate cancer (PCa) cells and its underlying mechanism. RT-qPCR analysis was performed examine expression sperm-specific antigen 2 (SSFA2) PCa tissues cells. Cell counting kit-8 (CCK-8) assay, 5-ethynyl-20-deoxyuridine (EdU) flow cytometry, wound-healing Transwell invasion assay were determine functional roles The association with SSFA2 determined by luciferase reporter RNA pull-down assays. found that...
Chronic abacterial prostatitis/chronic pelvic pain syndrome (CP/CPPS) accounts for 90% of clinical prostatitis, and there is no specific effective treatment it. Jiedu Huoxue decoction (JDHXD) has been believed to be an agent CP/CPPS, but the mechanism remains unclear.Carrageenan LPS were used established animal cell models respectively. The prostate index, urine volume, lumen area, epithelial thickness, response time investigated. TUNEL staining flow cytometry applied measure apoptosis...
The underlying mechanisms of Jiedu Huoxue decoction (JDHXD) in treating chronic prostatitis have not been fully explored.This study investigates the miRNAs as potential biomarkers and effect JDHXD on rat model experimental nonbacterial prostatitis.Fifty-four Sprague-Dawley male rats were randomly divided into normal control, model, low dose (0.5 g/kg/day), medium (1 high (2 g/kg/day) western medicine (cernilton 0.094 groups, intragastrically administered once daily for 30 days. control (upon...
Snakebites remain a major life-threatening event worldwide. It is still difficult to make positive identification of snake species by clinicians in both Western medicine and Chinese medicine. The main reason for this shortage diagnostic biomarkers lack knowledge about pathways venom-induced toxicity. In traditional medicine, snakebites are considered be treated with wind, fire, wind-fire toxin, but additional studies required.Cases snakebite seen at the Affiliated Hospital Jiangxi University...
Background. The majority of lung cancers are adenocarcinomas, with the proportion being 40%. patients mostly diagnosed in middle and late stages metastasis easy recurrence, which poses great challenge to treatment prognosis. Platinum-based chemotherapy is a primary for adenocarcinoma, frequently causes drug resistance. As result, it important uncover mechanisms chemoresponse adenocarcinoma platinum-based chemotherapy. Methods. genes from dataset GSE7880 were gathered into gene modules...
This study aimed to investigate the mechanism of Jiedu Huoxue decoction (JDHXD) in type III prostatitis based on NF-κB signalling pathway. Twenty-six Sprague-Dawley male rats were divided into blank control, model, positive (Prostate Plus), low-dose JDHXD, medium-dose JDHXD and high-dose groups. Type rat model was established confirmed with HE staining. NF-кB P50 P65 expression detected immunohistochemistry. mRNA qRT-PCR. Protein its inhibitor Iκ-Bα Western blot. Compared group, a decrease...
Elevated expression of lysyl oxidase-like 2 (LOXL2) contributes to the malignant tumor progression in multiple cancers. However, role LOXL2 5-fluorouracil (5-FU) resistance colorectal cancer (CRC) remains unclear. This study aimed explore effects on 5-FU sensitivity CRC. The mRNA and protein levels were explored public databases by bioinformatics, validated clinical tissues using immunohistochemistry, detected treated cell lines. 50% inhibitory concentrations (IC50) values quantified based...
Vinylboron compounds are important in organic chemistry and biology. In this communication, we developed a copper(I)-catalyzed, highly regio- stereoselective radical trans-hydroboration of ynamides with N-heterocyclic carbene (NHC)-ligated borane is reported, which leads to series trans-boryl enmides that can be conveniently transformed into various multi-substituted enamides. Further investigation showcased our method robust scalable. The mechanism unique reaction studied discussed.
N6-methyladenosine (m6A) is the most abundant internal modification on eukaryotic mRNAs. There increasing evidence that m6A plays a key role in tumor progression, so it important to analyze modifications within transcriptome-wide lung adenocarcinoma (LUAD). Three pairs of LUAD samples and tumor-adjacent normal tissues were obtained from South University Science Technology Hospital. And then methylated RNA immunoprecipitation sequencing (MeRIP-seq) (RNA-seq) used identify differential between...
Chronic prostatitis is a common andrological disease, which brings many troubles to the lives of middle-aged and elderly male patients. With increase modern life pressure, incidence chronic tends younger, but its etiology pathogenesis are not fully elucidated. Which seriously affects men's health? Relevant studies have shown that acupuncture combined with traditional Chinese medicine (TCM) has good effect on treatment compared conventional western medicine; however, there no consistent...
In the past decades, lung cancer is considered one of lethal cancers all across world due to its evidenced greatest mortality and morbidity. Currently, main clinical treatment methods for involve surgery, chemotherapy, radiotherapy, anti-angiogenesis inhibitors tyrosine kinase inhibitors. field anticancer drugs, a variety new drugs have been emerging in recent years. They include chemotherapy with delivery modes, targeted inhibitors, angiogenesis immunotherapy that remained hot. But because...