A5052835390- Acute Kidney Injury Research
- Renal and related cancers
- Reproductive Biology and Fertility
- Chronic Kidney Disease and Diabetes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cancer-related molecular mechanisms research
- Dialysis and Renal Disease Management
- Reproductive Physiology in Livestock
- interferon and immune responses
- Advanced Photocatalysis Techniques
- RNA modifications and cancer
- Nephrotoxicity and Medicinal Plants
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Mitochondrial Function and Pathology
- Immune Response and Inflammation
- Electrocatalysts for Energy Conversion
- Cytokine Signaling Pathways and Interactions
- Liver Disease Diagnosis and Treatment
- Renal function and acid-base balance
- Advanced battery technologies research
- Sperm and Testicular Function
- Reproductive System and Pregnancy
- Traditional Chinese Medicine Studies
- Cardiac Ischemia and Reperfusion
Fudan University
2016-2024
Zhongshan Hospital
2017-2024
Shanghai Blood Center
2018-2024
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Sun Yat-sen University
2021-2024
Shanghai Institute of Hematology
2018-2023
Shanghai Medical Information Center
2021-2023
Yangzhou University
2016-2023
Chongqing Technology and Business University
2023
Hunan Cancer Hospital
2020
Significance Aminoacyl-tRNA synthetases (AARSs) comprise a family of 20 enzymes that catalyze the first step protein synthesis by esterifying specific amino acids to 3′ ends their cognate tRNAs. Protein acetylation, an evolutionarily conserved posttranslational modification, has recently been extensively investigated regulate diverse cellular processes. This work provides molecular evidence one aminoacyl-tRNA is modulated reversible acetylation. study not only reveals regulatory mechanism...
Abstract Mounting evidence has indicated that long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) played important roles in renal ischemia/reperfusion (I/R) injury. However, the involvement of lncRNA growth arrest specific 5 (GAS5) acute kidney injury (AKI) remained largely unexplored. This study aimed to determine possible mechanisms GAS5 I/R process. We found GAS5, noticeably upregulated by injury, was further suppressed delayed IPC while knockdown miR-21 vivo before could significantly...
Abstract Acute kidney injury (AKI) has a critical role in the development of chronic disease (CKD). Building on our previous findings, we explored miR-382 facilitating transition AKI to CKD using Aristolochic acid (AA) nephropathy model, which was induced by intraperitoneal injection aristolochic I salt (10 or 20 mg/kg). The effects genetic depletion, pharmacologic inhibition, overexpression PTEN/AKT signaling pathway were examined vivo and vitro. Changes renal pathology epithelial polarity...
Background: There is limited evidence on the relationship between social isolation and renal outcomes. To address this gap, study estimated prospective of with rapid kidney function decline development chronic disease (CKD) in middle-aged elderly Chinese normal function. Methods: We analyzed data from 3,031 participants aged ≥ 45 years baseline glomerular filtration rates (eGFR) 60 ml/min/1.73 m2. All were obtained 2011 2015 waves Longitudinal Study Health Retirement (CHARLS). eGFR was based...
Accumulating evidence indicates that cellular and molecular abnormalities occur during oocyte aging, including fragmentation, increases in intracellular reactive oxygen species (ROS), abnormal Ca(2+) oscillations. The objective of the present study was to characterize relationships between ROS, homeostasis endoplasmic reticulum (ER), fragmentation aged porcine MII oocytes. Prolonged culture (36 h) oocytes resulted elevated ROS level, impaired ER (i.e., storage, rising patterns after...
ABSTRACT Aim Long non‐coding RNA (lncRNAs) have been shown to play a critical role in variety of pathophysiological processes, such as cell proliferation, apoptosis and migration. However, there were few studies addressing the function lncRNAs renal ischaemia/reperfusion (I/R) injury. Apoptosis is an important pathogenesis during I/R Here, we identified effect hypoxia‐responsive lncRNA growth arrest‐specific 5 (GAS5) on Methods Ischaemia/reperfusion injury mice or hypoxia/re‐oxygenation...
Introduction Hypertension and rising serum uric acid (sUA) played a pivotal role in the development of Chronic Kidney Disease (CKD). This study investigates interactive effect sUA hypertension on CKD identifies optimal threshold among individuals with without Chinese community population.
Oocyte-secreted factors (OSFs) maintain the low incidence of cumulus cell apoptosis. In this report, we described that presence oocytes suppressed expression proapoptotic protein BCL-2-interacting mediator death-extra long (BIMEL) in porcine cells. Atretic (terminal deoxynucleotidyl transferase dUTP nick end labeling-positive) cells strongly expressed BIMEL protein. The healthy cumulus- oocyte complex exhibited a while removal led to an about 2.5-fold (P < 0.5) increased oocytectomized...
Acute kidney injury (AKI) is a common complication after cardiac surgery, and preoperative renal dysfunction an important risk factor. Proteinuria indicates structural damage, but there are few studies on proteinuria the of AKI surgery in patients with dysfunction. This study aimed to elucidate whether can predict dysfunction.Patients stages 3-4 chronic disease (CKD) who underwent were included this retrospective study. was defined according KDIGO criteria. The association between CKD...
Imidazole, an organic alkaloid, is important pharmacophore in drug discovery. Anti-neoplastic potential of imidazole derivatives has been documented several studies; however, mechanisms by which tumor cells respond to these stimuli remain be elucidated. Autophagy and apoptosis have key roles tumorigenesis treatment. In this study, we systematically examined autophagic events induced HEC-1B cells. Accumulation vacuoles imidazole-treated was verified conversion LC3 protein, as well confocal...
Interferon (IFN)-stimulated gene 15 (ISG15) is one of several proteins induced by conceptus-derived Type I or II IFNs in the uterus, and implicated as an important factor determining uterine receptivity to embryos ruminants. But little known about role ISG15 product plays during embryo development. In present study, both expression profile function were investigated early bovine vitro. mRNA was detectable Day 0, 2, 6 8 embryos, but IFN-τ (IFNT) only appeared from 6. This means that embryonic...
TWIK-related acid-sensitive K+ channel-2 (TASK-2, encoded by Kcnk5) is essential in cell biological processes, regulating transmembrane balance. In the present study, we aimed to clarify role of TASK-2 renal fibrosis and explore underlying mechanism. We found that level was elevated tubular UUO- UIR-induced as well patients with tubulointerstitial fibrosis. Knockout Kcnk5 or inhibition tubules attenuated G2/M cell-cycle arrest alleviated Mechanistically, demethylase fat mass...
Abstract Acute kidney injury (AKI) is a common clinical dysfunction with complicated pathophysiology and limited therapeutic methods. Renal tubular the following regeneration process play vital role in course of AKI, but underlining molecular mechanism remains unclear. In this study, network-based analysis online transcriptional data human found that KLF10 was closely related to renal function, various diseases. Three classical mouse models confirmed downregulation AKI its correlation...
Remote ischemic preconditioning (RIPC) is an adaptive response, manifesting when local short-term reduces damage to adjacent or distant tissues organs. O-linked β-N-acetylglucosamine (O-GlcNAc) glycosylation of intracellular proteins denotes a type posttranslational modification that influences multiple cytoplasmic and nuclear protein functions. Growing evidence indicates stress can induce acute increase in O-GlcNAc levels, which be cytoprotective. The current study aimed determine whether...
Background: Acute kidney injury (AKI) is one of the more serious complications after cardiac surgery. Elevated red cell distribution width (RDW) was reported as a predictor for surgery associated acute (CSAKI). However, increment RDW by erythrocyte transfusion makes its prognostic role doubtful. The aim this study to elucidate impact on elevated predicting CSAKI. Methods: A total 3207 eligible patients who underwent during 2016–2017 were enrolled. Changes defined difference between...
Adherens junctions between tubular epithelial cells are disrupted in renal ischemia/reperfusion (I/R) injury. Syndecan-1 (SDC-1) is involved maintaining cell morphology. We aimed to study the role of SDC-1 shedding induced by I/R destruction intracellular adherens junctions. found that was increased while expression E-cadherin decreased. This observation accompanied activation STAT3 kidneys. Inhibiting could alleviate this effect. Mild induce more severe injury, lower expression, damaged...