A5023513286- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Analytical Chemistry and Chromatography
- Drug Transport and Resistance Mechanisms
- Cancer Genomics and Diagnostics
- Barrier Structure and Function Studies
- HIV/AIDS drug development and treatment
- Pharmaceutical studies and practices
- Microfluidic and Capillary Electrophoresis Applications
- Polysaccharides and Plant Cell Walls
- Advancements in Transdermal Drug Delivery
- Catalytic Cross-Coupling Reactions
- Cancer Treatment and Pharmacology
- Prostate Cancer Treatment and Research
- Plant Molecular Biology Research
- Chromatography in Natural Products
- Asymmetric Hydrogenation and Catalysis
- Leaf Properties and Growth Measurement
- Cancer Immunotherapy and Biomarkers
- HIV/AIDS Research and Interventions
- Cancer therapeutics and mechanisms
- Treatment of Major Depression
- Extracellular vesicles in disease
- Mesenchymal stem cell research
University of North Texas
2016-2024
University of North Texas Health Science Center
2016-2024
China Pharmaceutical University
2021-2023
China Tobacco
2023
University of North Texas System
2018-2022
Unimed Medical Institute
2018-2019
East China Normal University
2019
New York University Shanghai
2019
Ruijin Hospital
2016
Shanghai Jiao Tong University
2016
To test the ability of nanoparticle formulations to overcome P-glycoprotein (P-gp)-mediated multidrug resistance, several different doxorubicin and paclitaxel-loaded lipid nanoparticles were prepared. Doxorubicin showed 6- 8-fold lower IC(50) values in P-gp-overexpressing human cancer cells than those free doxorubicin. The value paclitaxel was over 9-fold that Taxol cells. A series vitro cell assays used including quantitative studies on uptake efflux, inhibition calcein acetoxymethylester...
The objectives of these studies were to investigate and compare solid lipid nanoparticles (SLNs) two anthracyclines, idarubicin (IDA) doxorubicin (DOX), against Pgp-mediated multiple drug resistance (MDR) in-vitro in-vivo using different human murine cancer cell models. IDA DOX SLNs developed from warm microemulsion precursors comprising emulsifying wax as the oil phase, polyoxyl 20-stearyl ether (Brij 78) D-alpha-tocopheryl polyethylene glycol succinate (Vitamin E TPGS) surfactants. Anionic...
Abstract Background Non-small cell lung cancer (NSCLC) is one of the most common human malignancies and leading cause cancer-related death. Over past few decades, genomic alterations driver genes have been identified in NSCLC, molecular testing targeted therapies become standard care for patients. Here we studied unique profile Chinese patients with NSCLC by next-generation sequencing (NGS) assay. Materials Methods A total 1,200 were enrolled this study. The median age was 60 years (range:...
Metformin, an anti-diabetes drug, has been recently emerging as a potential "anti-aging" intervention based on its reported beneficial actions against aging in preclinical studies. Nonetheless, very few metformin studies using mice have determined concentrations and many effects of observed doses/concentrations that were not relevant to therapeutic levels human. We developed liquid chromatography-tandem mass spectrometry protocol for measurement plasma, liver, brain, kidney, muscle mice....
Disorders of the brain constitute most debilitating situation globally with increased mortality rates every year, while physiology and cumbersome drug development processes exacerbate this. Although blood-brain barrier (BBB) its components are important for protection, their complexity creates major obstacles delivery, BBB is primary cause treatment failure, leading to disease progression. Therefore, developing an ideal platform that can predict behavior a delivery system in at early phase...
Most prostate cancer patients develop resistance to anti-androgen therapy. This is referred as castration-resistant (CRPC). Docetaxel (DTX) the mainstay treatment against CRPC. However, over time eventually DTX resistance, which cause of cancer-related mortality. Curcumin (CUR) a natural compound has been shown have very broad pharmacological activities, e.g., anti-inflammatory and antioxidant properties. CUR hydrophobic. The objective this study was nanoparticles (NPs) evaluate their...
Planar chiral 1,1′P,N-2′-substituted 2′ substituted 1,1′-P,N-ferrocene derivatives were efficient ligands for the Pd-catalyzed asymmetric Heck reaction, in which 79–85% yields with high enantioselectivity (80–92%) obtained within several hours; and absolute configuration controllable by changing size of planar group and/or chirality.
Pain has been found to promote reward-seeking behaviors, which might be a consequence of modulated brain activities in the reward neural circuitry painful state. The present study investigated how pain affected processing and reward-related using fMRI technique. A total 50 healthy participants were recruited used for data analyses, with half being treated topical capsaicin cream other hand (treatment: or control). asked perform card-guessing game when their responding feedbacks (outcome: win...
Purpose: The purpose of this study was to develop a novel lipid-based nanotechnology formulate poorly water-soluble drugs in oral solid granules improve stability, palatability, and bioavailability. Materials methods: In one method, we prepared ritonavir (RTV) nanoparticles (NPs) by microemulsion-precursor method then converted the RTV NPs wet granulation produce NP-containing granules. other innovative did not use water formulation preparation, discovered situ self-assembly (ISNPs). We ISNP...
Chrysanthemum morifolium cv. Fubaiju is rich in phenolic compounds with various benefits such as anti‐inflammatory, antioxidant, and cardiovascular protection. In this study, 12 compounds, including five flavonoid glycosides seven quinic acid derivatives, were successfully separated from the flowers of by high‐speed counter‐current chromatography preparative high‐performance liquid chromatography. Ethyl acetate‐ n ‐butanol–acetonitrile–water–acetic (5:0.5:2.5:5:0.25, v/v/v/v/v) was selected...
Oral delivery of chemotherapy drugs is the most favorable and preferred route drug administration. However, because poor solubility and/or permeability, are given by intravenous Docetaxel (DTX) a potent that inhibits microtubular depolymerization widely used to treat numerous cancers. DTX highly lipophilic insoluble in water; thus, 50% polysorbate 80, which may cause hypersensitivity reactions reduce uptake tumor tissue, commercial injection dissolve DTX. Maximum tolerated dose (MTD)...
Quetiapine fumarate (QF) is an atypical antipsychotic used off-label for the treatment of delirium in critically-ill infants and children. For pediatric populations or patient with trouble swallowing tablets, oral suspension would be ideal dosage formulation. However, there are no liquid formulations QF commercially available. Therefore, a compounded prepared from commercial tablets widely clinical settings. The extemporaneous preparation changes formulation solid form to form. Thus,...
Most antiretroviral medications for human immunodeficiency virus treatment and prevention require high levels of patient adherence, such that need to be administered daily without missing doses. Here, a long-acting subcutaneous injection lopinavir (LPV) in combination with ritonavir (RTV) using situ self-assembly nanoparticles (ISNPs) was developed potentially overcome adherence barriers. The ISNP approach can improve the pharmacokinetic profiles drugs. ISNPs were characterized terms...
Metronomic chemotherapy, giving low doses of chemotherapeutics (e.g., docetaxel) on a frequent schedule over long time, may improve outcomes and reduce side effects for cancer patients. Oral medications are vital applying metronomic chemotherapy. However, solubility, absorption, drug availability in the targeted tissue, limit development oral chemotherapeutics. Many intravenously delivered. In this work, we developed new docetaxel granule that produces docetaxel-loaded situ self-assembled...
Programmed cell death-ligand 1 (PD-L1) immunohistochemistry score has been approved as the predictive biomarker for anti-PD1/PD-L1 therapy in several advanced malignancies. Although its role remained inconclusive hepatocellular carcinoma, ongoing study of showed promising results. However, less is known about PD-L1 and factors correlated with it carcinoma. We investigated scores a large cohort well correlation various clinical genomic factors.Immunohistochemistry was performed to detect...
The objective of this article is to introduce preparation and characterization methods for nerve growth factor (NGF)-loaded, high-density, lipoprotein (HDL)-mimicking nanoparticles (NPs). HDLs are endogenous NPs have been explored as vehicles the delivery therapeutic agents. Various developed prepare HDL-mimicking NPs. However, they generally complicated, time consuming, difficult industrial scale-up. In study, one-step homogenization was used mix excipients form prototype NGF a...