A5100399721- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- interferon and immune responses
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Influenza Virus Research Studies
- Cardiac electrophysiology and arrhythmias
- Liver Diseases and Immunity
- Genetic Associations and Epidemiology
- Gestational Diabetes Research and Management
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Respiratory viral infections research
- Anesthesia and Sedative Agents
- Pregnancy and preeclampsia studies
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- Cardiovascular Issues in Pregnancy
- Congenital Heart Disease Studies
- ECG Monitoring and Analysis
- Sphingolipid Metabolism and Signaling
- Ginkgo biloba and Cashew Applications
- Extracellular vesicles in disease
- Heart rate and cardiovascular health
Northwest A&F University
2025
Nanjing University of Chinese Medicine
2020-2024
Center for Disease Control
2024
Kunming Medical University
2024
Hangzhou Center for Disease Control and Prevention
2024
Zhejiang Center for Disease Control and Prevention
2024
Jiangsu Province Hospital
2022-2024
Nanjing Medical University
2024
Dalian Municipal Central Hospital
2024
Dalian University of Technology
2024
Background: The sodium-dependent glucose co-transporter 2 (SGLT2) is a high-capacity, low-affinity transport system primarily expressed in the renal proximal tubules, where it plays an important role regulation of levels. Inhibition SGLT2 represents innovative approach for plasma control type diabetes mellitus (T2DM) by blocking reabsorption and enhancing loss urine. Methods: This Phase 2, randomized, placebo-controlled study investigated safety, tolerability, pharmacokinetic pharmacodynamic...
Background/purpose Metabolic-associated fatty liver disease (MAFLD) is a major cause of chronic worldwide and generally thought to be closely related obesity diabetes. However, it also affects non-obese individuals, particularly in Asian cultures. Methods Healthy physical examination subjects MAFLD patients were included the endocrinology department Jiangsu Provincial Hospital Traditional Chinese Medicine. was defined as imaging without virus infection, drug, alcohol, or other known causes...
Dexmedetomidine plays a pivotal role in mitigating postoperative delirium and cognitive dysfunction while enhancing the overall quality of life among surgical patients. Nevertheless, influence dexmedetomidine on such complications various anaesthesia techniques remains inadequately explored. As such, present study, meta-analysis was conducted to comprehensively evaluate its effects dysfunction.
Thyroid hormones (THs) have been found that it is closely associated with the onset and progression of non-alcoholic fatty liver disease (NAFLD). However, current study could not verify intrinsic relationship between thyroid NAFLD, which requires further research. The searches studies reported both TH level in serum NAFLD were performed PubMed, Web Science, Cochrane Library, Embase databases. We combined an overall meta-analysis a dose-response to assess correlation function levels risk...
Land use change driven by vegetation succession significantly enhances soil carbon storage, yet the microbial mechanisms underlying this process remain poorly understood. This study aims to elucidate mechanistic linkages between bacterial community dynamics and organic matter stabilization across four stages on Loess Plateau: abandoned farmland (AF), grassland stage (GS), shrub-land (SS), forest (FS). We analyzed (SOM_C) fractions, physicochemical properties, communities (16S rRNA...
Objective: Type 2 diabetes (T2D) is a risk factor for cognitive impairment and cerebral small vessel disease (CSVD). The relation of metformin use or CSVD not clear. objective this study was to investigate the cross-sectional effects long-term on total burden function in patients with T2D. Methods: A 234 participants T2D from memory clinic Hebei General Hospital were enrolled retrospective study. Duration dosage recorded. Along magnetic resonance imaging (MRI) examination, Mini-Mental State...
OBJECTIVES: Severe cases of COVID-19 pneumonia can lead to acute respiratory distress syndrome (ARDS). Release interleukin (IL)-33, an epithelial-derived alarmin, and IL-33/ST2 pathway activation are linked with ARDS development in other viral infections. IL-22, a cytokine that modulates innate immunity through multiple regenerative protective mechanisms lung epithelial cells, is reduced patients ARDS. This study aimed evaluate safety efficacy astegolimab, human immunoglobulin G2 monoclonal...
Endothelial cells (EC) play essential roles in retinal vascular homeostasis. This study aimed to characterize EC heterogeneity and functional diversity using single-cell RNA sequencing. Systematic analysis of cellular compositions cell-cell interaction networks identified a unique cluster with high inflammatory gene expression diabetic retina; sphingolipid metabolism is prominent aspect correlated changes function. Among sphingolipid-related genes, alkaline ceramidase 2 (ACER2) showed the...
Heart rate-corrected QT interval (QTc) prolongation is prevalent in patients with severe coronavirus disease 2019 (COVID-19) and associated poor outcomes. Recent evidence suggests that the exaggerated host immune-inflammatory response characterizing disease, specifically interleukin-6 (IL-6) increase, may have an important role, possibly via direct effects on cardiac electrophysiology. The aim of this study was to dissect short-term discrete impact IL-6 elevation QTc COVID-19 infection...
Abstract Background Diabetes is a progressive condition requiring long-term medical care and self-management. The ineffective transition from hospital to community or home health may result in poor glycemic control increase the risk of serious diabetes-related complications. In China, most common transitional model visits telephone interventions led by single healthcare setting, with lack cooperation between specialists primary care, which leads inadequate service discontinuous care. Thus,...
Abstract Upper gastrointestinal bleeding (UGIB) is common in liver cirrhosis. Although esophageal and gastric varices (EGV) the main source, there were still a proportion of patients with peptic ulcer bleeding. Thus, this study aimed to analyze characteristic variceal Cirrhotic confirmed UGIB by urgent endoscopy from July 2012 June 2018 enrolled, classified into group (n = 248) 402). Clinical endoscopic characteristics, therapeutic efficacy prognosis evaluated, independent risk factors for...
Abstract Background Use of sedatives and analgesics is associated with the occurrence delirium in critically ill patients receiving mechanical ventilation. Dexmedetomidine reduces but may cause hypotension, bradycardia, insufficient sedation. This substudy aims to determine whether combination esketamine dexmedetomidine can reduce side effects risk than alone mechanically ventilated patients. Methods single-center, randomized, active-controlled, superiority trial will be conducted at The...
What is the central question of this study? The therapeutic effect ivabradine on patients with chronic heart failure and stable angina pectoris mediated through a reduction in rate: what are haemodynamic characteristics mechanism inotropic effect? main finding its importance? Ivabradine has positive lowers rate both vivo vitro. These effects likely by ivabradine's significant increase fast component constant sarcoplasmic/endoplasmic reticulum calcium ATPase 2a decrease slow that Na+ /Ca2+...
In the present study, ability of ethanol extract from Potentilla anserina L (PAEE) to reduce lipid accumulation induced by oleic acid (OA) in HepG2 cells and anti-hyperlipidemia effect high-fat diet-fed mice were investigated. The results revealed that PAEE containing six major phenolic compounds which could significantly droplets OA-induced cells. Meanwhile, vivo not only improved level fasting blood glucose, but also reduced TG TC serum obese mice. Furthermore, expression adipogenic genes...
Abstract Amenamevir is the international non‐proprietary name for ASP2151 synthesized by Astellas Pharma, Inc. It a structurally novel class of helicase‐primase inhibitor and demonstrated more potency in vitro anti‐viral activity with low cytotoxicity against varicella‐zoster virus (VZV), herpes simplex type 1 (HSV‐1), 2 (HSV‐2) than acyclovir (ACV). Phase II randomized trial assessed safety efficacy episodic therapy recurrent genital was conducted. Participants self‐initiated (100, 200, or...
Sex and reproductive status differences exist in both non-alcoholic fatty liver disease (NAFLD) body composition. Our purpose was to investigate the relationship between composition severity of steatosis fibrosis NAFLD different sex populations.This cross-sectional study included 880 patients (355 men, 417 pre-menopausal women, 108 post-menopausal women). Liver data were measured using FibroScan a bioelectrical impedance analyzer (BIA), respectively, following parameters obtained: stiffness...
Esophagogastric variceal bleeding (EGVB) is a potentially life-threatening complication of portal hypertension. Endoscopic treatment combined with pharmacotherapy remains the mainstay in management acute bleeding.This article intends to highlight potential differences endoscopic EGVB China.A cross-sectional descriptive study was conducted. Endoscopists from 85 hospitals 62 cities 26 provinces were contacted by email. The items questionnaire involved academic experience, screening,...