A5061340662- Comparative Animal Anatomy Studies
- Genetic and phenotypic traits in livestock
- Pediatric Hepatobiliary Diseases and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Congenital Ear and Nasal Anomalies
- Congenital Anomalies and Fetal Surgery
- Gallbladder and Bile Duct Disorders
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Hormonal and reproductive studies
- Alzheimer's disease research and treatments
- Livestock Management and Performance Improvement
- Agricultural and Food Sciences
- Intestinal Malrotation and Obstruction Disorders
- Veterinary Equine Medical Research
- Cleft Lip and Palate Research
- Soil Management and Crop Yield
- Medicinal Plants and Neuroprotection
- Rural Development and Agriculture
- Cardiovascular Conditions and Treatments
- Tannin, Tannase and Anticancer Activities
- dental development and anomalies
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Neurological diseases and metabolism
Parthenope University of Naples
2021-2024
Azienda Usl Toscana Centro
2024
University of Siena
2020-2023
Universidade de São Paulo
1975-1988
Background: During acute infections, the risk of malignant ventricular arrhythmias is increased, partly because a higher propensity to develop QTc prolongation. Although it generally believed that changes almost exclusively result from concomitant treatment with QT-prolonging antimicrobials, direct effects inflammatory cytokines on repolarization are increasingly recognized. We hypothesized systemic inflammation per se can significantly prolong during via cytokine-mediated in K + channel...
Alzheimer's disease (AD) is the most common neurodegenerative pathology among progressive dementias, and it characterized by accumulation in brain of extracellular aggregates beta-amyloid proteins neurofibrillary intracellular tangles consisting τ-hyperphosphorylated proteins. Under normal conditions, peptides exert important trophic antioxidant roles, while their massive presence leads to a cascade events culminating onset AD. The fibrils are formed process fibrillogenesis that, starting...
Background: Alzheimer’s disease (AD) and Parkinson’s (PD) are multifactorial neurodegenerative disorders that mostly treated with drugs inhibiting key enzymes of cholinergic aminergic neurotransmission, such as acetyl butyryl cholinesterase (AChE, BuChE) or monoamine oxidases (MAO)-A/B, Aβ 1–40 aggregation. Diet plant components multitarget functions promising compounds in the prevention AD PD. Our aim was to identify neuroprotective from Annurca apple polyphenol extract (AFPE). Methods:...
Background Recent data suggest that systemic inflammation can negatively affect atrioventricular conduction, regardless of acute cardiac injury. Indeed, gap‐junctions containing connexin43 coupling cardiomyocytes and inflammation‐related cells (macrophages) are increasingly recognized as important factors regulating the conduction in node. The aim this study was to evaluate impact inflammatory activation on elucidate underlying mechanisms. Methods Results We analyzed: (1) PR‐interval...
Alzheimer's (AD) and Parkinson's diseases (PD) are multifactorial neurogenerative disorders of the Central Nervous System causing severe cognitive motor deficits in elderly people. Because treatment AD PD by synthetic drugs alleviates symptoms often inducing side effects, many studies have aimed to find neuroprotective properties diet polyphenols, compounds known act on different cell signaling pathways. In this article, we analyzed effect polyphenols obtained from agro-food industry waste...
Soccer match requires anaerobic and aerobic energetic metabolism. The aim of this pilot study was to investigate the changes in blood lactate concentration young male soccer players different playing roles at time points after match.
Background. Men normally have shorter heart rate-corrected QT interval (QTc) than women, at least in part due to accelerating effects of testosterone on ventricular repolarization. Increasing data suggest that androgen-deprivation therapy (ADT) used for the treatment prostatic cancer, may increase torsades de pointes (TdP) risk by prolonging QTc. However, evidence such an association is currently limited few case reports, most cases deriving from analysis uncontrolled sources as...
Among matrix metalloproteinases (MMPs), MMP-9/2 are key enzymes involved in the proteolysis of extracellular matrices inflammatory process and cancer. Since expression levels, activity, secretion is up-regulated during inflammation response to pro-inflammatory cytokines, such as interleukin-6 (IL-6), many efforts have been devoted identifying factors that could inhibit IL-6-induced expression. Up now, several reports indicated polyphenols from fruits vegetables among major components health...
Heart rate-corrected QT interval (QTc) prolongation is prevalent in patients with severe coronavirus disease 2019 (COVID-19) and associated poor outcomes. Recent evidence suggests that the exaggerated host immune-inflammatory response characterizing disease, specifically interleukin-6 (IL-6) increase, may have an important role, possibly via direct effects on cardiac electrophysiology. The aim of this study was to dissect short-term discrete impact IL-6 elevation QTc COVID-19 infection...
Background Systemic inflammation and male hypogonadism are 2 increasingly recognized "nonconventional" risk factors for long-QT syndrome torsades de pointes (TdP). Specifically, inflammatory cytokines prolong, while testosterone shortens the heart rate-corrected QT interval (QTc) via direct electrophysiological effects on cardiomyocytes. Moreover, several studies demonstrated important interplays between reduced gonad function in men. We hypothesized that, during activation men, levels...
Monoamine oxidase and xanthine inhibitors represent useful multi-target drugs for the prevention, attenuation, treatment of oxidative damage neurodegenerative disorders. Chimeric molecules, constituted by naturally derived compounds linked to drugs, lead be explored discovery new synthetic acting as enzyme inhibitors. We have previously reported that seven hydroxytyrosol-donepezil hybrid play a protective role in an vitro neuronal cell model Alzheimer’s disease. In this work, we analyzed...
Actinomyces species are recognized as common mucosal bacteria in humans and a newly discovered source of infection. Since its discovery 1995, the subspecies turicensis has been reported causative pathogen numerous infections. Only two instances A. turicensis-related empyema, however, have documented literature late. We report unique case polymicrobial empyema caused by shortly after COVID-19 without any clear risk factors for anaerobic aspiration, along with brief review literature....
Cannabidiolic (CBDA) and cannabigerolic (CBGA) acids are naturally occurring compounds from Cannabis sativa plant, previously identified by us as dual PPARα/γ agonists. Since the development of multitarget-directed ligands (MTDL) represents a valuable strategy to alleviate slow down progression multifactorial diseases, we evaluated potential ability CBDA CBGA also inhibit enzymes involved in modulation cholinergic tone and/or β-amyloid production. A multidisciplinary approach based on...
Abstract Aims The presence of anti‐human leucocyte antigen (HLA) antibodies has been implicated in a higher incidence complications as well mortality rate heart transplantation. aim the study was to identify through non‐invasive parameters early signs myocardial dysfunction anti‐HLA but without evidence antibody‐mediated rejection (AMR) and its possible prognostic impact. Methods results A total 113 heart‐transplanted patients acute cellular (ACR) AMR or cardiac allograft vasculopathy (CAV)...
Among inflammatory cytokines, Interleukin-6 (IL-6) is one of the major activators acute phase response and also involved in immune cancer progression. IL-6 up-regulation enzymes growth factors acting on extracellular matrix (ECM) remodelling components physio-pathological processes. enhances expression metalloproteases (MMP-)2/9, that play a key role ECM degradation therefore contribute to process tumor metastasis. To counteract and/or prevent diseases, many efforts have been devoted...
Foi observada a origem
Estudando a irrigação do nó sinu-atrial em 40 corações de cães da raça Pequinês, 22 machos e 18 fêmeas, com diferentes não conhecidas idades, mediante uso método diafanização Spaltholz, pudemos verificar que: a) o suprimento sanguíneo aludido território depende, mais comumente (85,0% ± 5,6), colaterais artéria coronária dextra, vale dizer, ramus distalis atrii dextri, 26 vezes (65,0% 7,5) ou, intermedius 8 (20,0% 6,3) ; b) algumas peças (10,0% 6,8) região tecido nodal é nutrida por ambas as...
A group of 25 mongrel, adult dogs, 24 males and 2 females, native from an endemic area dirofiIariasis (Guarujá) was studied. The animals were submitted to blood analysis for microfilaremia radiologic, electrocardiographic necroscopic examinations. Sixteen dogs (61,53%) showed circulating microfilariae. examination revealed the presence parasites in 22 (84,61%); (84,61%) radiographic alterations which may be related electrocardiogram abnormalities 14 (53,84%). most common alteration...
The AA. studied the ductus parotideus opening in 117 heads of thoroughbred horses, 69 males and 48 females related it to vestibular surface upper cheek teeth, or better, to: 1st) ridge that demarcates grooves 2nd premolar — 73 pairs (62.4% ± 4.5 42 31 females, from 2 4 years old). 2nd) contact line between 3rd premolars 37 (31.6% 4.3 23 14 6 3rd) 1st 5 (4.3% 1.9 3 days 1 year 4th) (1.7% < .2 male female, 8 13 bi-lateral symmetry pnrotideus was always evident. Sex did not influence parotideus.
The AA. studied the ductus parotideus opening in 83 heads of buffaloes, 24 males and 59 females, related it to vestibular surface upper cheek teeth, or better, to: 1st) contact line between 1st molars — 64 pairs (77.1% ± 4.6 18 46 females); 2nd) molar 15 (18.1% 4 . 2 6 9 3d) 2nd (4.8% 3 females). bi-lateral symmetry was always evident.
It was studied the topographic situation of parotid papilla related to upper premolar and molar teeth, in 230 dogs different breeds grouped MEGNIN'S read types. Generally is seem at level space between 4th pre 1sl jaw but it also other teeth or interdental spaces, according diverse head types, that are associated three skull types; i.e.: DoIicocephaIic , MesaticephaIic Brachycefalic.
The biliary ducts of 15 capybaras (Hydrochoerus Hydrochoeris) , adults (10 males and 5 females) Were studied by dissection. results show that: 1) the ductus choledocus union ramus principalis dexter, sinister cysticus (66.7%), dexter (19.8%) or hepaticus (13.3%); 2 ) is characterized in 13 .3% cases always formed convergence sinister; 3) cysticus, has not affluents some (92.4%); others case it receives medialis lobi dextri associated to quadrati (6.7%). contributes directly formation with...