A5030405728- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Forensic Toxicology and Drug Analysis
- Psychedelics and Drug Studies
- Herbal Medicine Research Studies
- Gastrointestinal disorders and treatments
- Sexual function and dysfunction studies
- Nicotinic Acetylcholine Receptors Study
- Neurogenesis and neuroplasticity mechanisms
- Ion Channels and Receptors
- Traumatic Brain Injury Research
- Tumors and Oncological Cases
- Neonatal and fetal brain pathology
- Dermatology and Skin Diseases
- Adipose Tissue and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Cholinesterase and Neurodegenerative Diseases
- Complementary and Alternative Medicine Studies
- Biochemical effects in animals
- Memory and Neural Mechanisms
- Pain Mechanisms and Treatments
- Gastrointestinal Tumor Research and Treatment
- Medical Imaging and Pathology Studies
- GABA and Rice Research
University of Campania "Luigi Vanvitelli"
2023-2024
University of Rome Tor Vergata
2023
Abstract Cannabis is a multifaceted plant with numerous therapeutic properties on one hand, and controversial psychotropic activities the other which are modulated by CB1 endocannabinoid receptors. Δ9-Tetrahydrocannabinol (Δ9-THC) has been identified as main component responsible for effects, while its constitutional isomer cannabidiol (CBD) shown completely different pharmacological properties. Due to reported beneficial gained global popularity openly sold in shops online. To circumvent...
Transient global amnesia, both persistent and transient, is a very common neuropsychiatric syndrome. Among animal models for amnesia testing new drugs, the scopolamine test most widely used transient (TGA). This study examined scopolamine-induced deficits in working memory, discriminative anxiety, motor activity presence of intranasal PEA-OXA, dual antagonist presynaptic α2 H3 receptors. Male C57BL/6 mice were treated with intraperitoneal (1 mg/kg) or without pre-treatment (15 min)...
Vestibulodynia is a complex pain disorder characterized by chronic discomfort in the vulvar region, often accompanied tactile allodynia and spontaneous pain. In patients depressive behaviour also observed. this study, we have used model of vestibulodynia induced complete Freund's adjuvant (CFA) focusing our investigation on spinal cord neurons microglia. We investigated allodynia, pain, depressive-like behavior as key behavioral markers vestibulodynia. addition, conducted vivo...
Traumatic brain injuries (TBI) refer to multiple acquired dysfunctions arising from damage the caused by an external force, including rapid acceleration/deceleration and concussion. Among them, mild TBI (mTBI) accounts for most cases (up 90%) of injuries. It is responsible a variety symptoms, anxiety, depression, cognitive impairments that remain difficult be treated. has been reported regular physical activity, as well as, improving life quality, display neuroprotective function, suggesting...
This report describes the case of a 56-year-old woman who presented at emergency room with 3-week history severe, intermittent abdominal pain. A CT scan revealed colo-colic intussusception caused by large, substenosing mass predominant adipose density. Subsequent endoscopic examination biopsy necrotic tissue covering mass, without definitive histological characterization. second led to extremely rare diagnosis lipoma. While is in adults, it's important consider it as differential diagnosis,...
Vulvodynia is a chronic pain condition that affects the vulvar area, often resulting in significant discomfort and reduced quality of life. Current treatments for vulvodynia are limited, there need more effective therapeutic options. Acmella oleracea, known its spilanthol content, Boswellia serrata, rich boswellic acids, have been explored their potential analgesic properties management. In this study, vulvodynia-like symptoms were induced female mice using Complete Freund's adjuvant (CFA)....
Cannabidiolic (CBDA) and cannabigerolic (CBGA) acids are naturally occurring compounds from Cannabis sativa plant, previously identified by us as dual PPARα/γ agonists. Since the development of multitarget-directed ligands (MTDL) represents a valuable strategy to alleviate slow down progression multifactorial diseases, we evaluated potential ability CBDA CBGA also inhibit enzymes involved in modulation cholinergic tone and/or β-amyloid production. A multidisciplinary approach based on...
Abstract Cannabis is a double-faced plant with uncountable therapeutic properties, on one side, and controversial psychotropic activities, the other modulated by CB1 endocannabinoid receptors. Δ 9 -Tetrahydrocannabinol (Δ -THC) has been identified as main component responsible for effects, while its isomer cannabidiol (CBD) shown completely different pharmacological properties. Based remarkable beneficial spread worldwide it openly sold in shops online. In order to overcome restrictions due...
Objectives: This study proposes to present Magnetic resonance imaging (MRI) with Diffusion Weighted Imaging (DWI) sequences and Apparent Coefficient (ADC) maps as an innovative safe method for pulmonary nodule characterization, comparing it PET-CT 18FDG prove that MRI is promising alternative technique in distinguishing benign from malignant solitary nodules, without presenting significant differences predict the malignancy of nodules.Methods: A prospective 50 nodules 48 patients isolated...