A5087166179- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- ECG Monitoring and Analysis
- Long-Term Effects of COVID-19
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- SARS-CoV-2 and COVID-19 Research
- Cardiac Imaging and Diagnostics
- COVID-19 Clinical Research Studies
University of Siena
2017-2024
Although accumulating data indicate that IL-6 (interleukin-6) can promote heart rate-corrected QT interval (QTc) prolongation via direct and indirect effects on cardiac electrophysiology, current evidence comes from basic investigations small clinical studies only. Therefore, is still largely ignored in the management of long-QT syndrome related arrhythmias. The aim this study was to estimate risk QTc associated with elevated levels a large population unselected subjects.
Heart rate-corrected QT interval (QTc) prolongation is prevalent in patients with severe coronavirus disease 2019 (COVID-19) and associated poor outcomes. Recent evidence suggests that the exaggerated host immune-inflammatory response characterizing disease, specifically interleukin-6 (IL-6) increase, may have an important role, possibly via direct effects on cardiac electrophysiology. The aim of this study was to dissect short-term discrete impact IL-6 elevation QTc COVID-19 infection...
Advanced atrioventricular block (AVB), that is, higher than second-degree Mobitz-1, is an abnormal finding in athletes. Despite intensive investigation, several cases the pathogenesis remains unknown, but frequently pacemaker implantation still indicated. Increasing evidence points to circulating anti-Ro/Sjögren syndrome-related antigen A (SSA) antibodies cross-reacting with L-type calcium channel and inhibiting related current as epidemiologically relevant potentially reversible cause of...
Severely ill patients with coronavirus disease 2019 (COVID-19) show an increased risk of new-onset atrioventricular blocks (AVBs), associated high rates short-term mortality. Recent data suggest that the uncontrolled inflammatory activation observed in these patients, specifically interleukin (IL)-6 elevation, may play important pathogenic role by directly affecting cardiac electrophysiology. The aim our study was to assess acute impact IL-6 changes on electrocardiographic indices conduction...
Abstract Background The electrocardiographic (ECG) definition of Brugada syndrome (BS) can be challenging because benign ECG abnormalities, such as right bundle branch block (RBBB), may mimic pathological characteristics BrS. However, although myocardial delay and deformation quantified by advanced imaging, it has not yet been used to differentiate between BrS RBBB. Purpose aim this study was characterize the electro-mechanical behavior heart patients with type-1 subjects isolated complete...