An ecofriendly synthetic pathway for the synthesis of donepezil precursors is described. Alternative energy sources were used total in order to improve yields, regioselectively, and rate each step reduce coproduction waste at same time. For all products, characterized by an improved structural rigidity respect donepezil, inhibitor activity on AChE, selectivity vs BuChE, side-activity BACE-1, effect SHSY-5Y neuroblastoma cells viability tested. Two potential new lead compounds a dual...

In this new century, sustainable development challenges chemical sciences to develop and clean technological processes. The agri-food industry produces significant quantities of waste, raising economic environmental concerns. Food waste valorization using environmentally friendly procedures is increasing importance. This study describes the use several Natural Deep Eutectic Solvents (NADESs) for microwave-assisted extraction (MAE) valuable bioactive phenolic compounds from olive oil...

Mercury pollution poses a global health threat due to its high toxicity, especially in seafood where it accumulates through various pathways. Developing effective and affordable technologies for mercury removal from water is crucial. Adsorption stands out as promising method, but creating low-cost materials with selectivity capacity adsorption challenging. Here we show sustainable method synthesize sulfhydrylated cellulose ethylene sulfide functionalities bonded glucose units....

The transformation of furfural into functionalized cyclopentenone derivatives is a smart process to advance the sustainable synthesis important chemicals from biomass.

The exploitation and use of alternative synthetic methods, in the face classical procedures that do not conform to ethics green chemistry, represent an ever-present problem pharmaceutical industry. for synthesis benzimidazoles have become a focus organic as they are building blocks strong interest development compounds with pharmacological activity. Various benzimidazole derivatives exhibit important activities such antimicrobial, antiviral, anti-inflammatory, analgesic activities, some...

1,2,3-triazoles represent a functional heterocyclic core that has been at the center of modern organic chemistry since beginning click chemistry. Being versatile framework, such an aromatic ring can be observed in uncountable molecules useful medicine and photochemistry, just to name few. This review summarizes progress achieved their synthesis from 2015 today, with particular emphasis on development new catalytic eco-compatible approaches. In doing so, we subdivided report based degree...

Hydroxymethylfurfural (HMF) derived from sugars through an environmentally friendly process catalysed by metal triflate/choline chloride system is presented in this study.

In this paper, a Q-tube equipment is proposed as valid alternative to monomode MW technology synthesize in simple and economic way library of dihydropyrimidine derivatives performing the Biginelli reaction solvent-free conditions under pressure with catalysis very mild environmentally benign Lewis acid consisting erbium trichloride hexahydrate.

The development of novel synthetic routes to produce bioactive compounds starting from renewable sources has become an important research area in organic and medicinal chemistry. Here, we present a low-cost procedure for the tunable selective conversion biomass-produced furfural cyclopentenone derivatives using mixture choline chloride urea as biorenewable deep eutectic solvent (DES). proposed medium is nontoxic, biodegradable, could be reused up four times without any unfavorable effect on...

In this paper a new catalyst-free and on-water method for protection of amines amino acids with di-<italic>tert</italic>-butyl dicarbonate, 9-fluorenylmethoxycarbonyl chloride, acetyl chloride tosyl is presented.

Alzheimer's disease (AD) is the most common neurodegenerative pathology among progressive dementias, and it characterized by accumulation in brain of extracellular aggregates beta-amyloid proteins neurofibrillary intracellular tangles consisting τ-hyperphosphorylated proteins. Under normal conditions, peptides exert important trophic antioxidant roles, while their massive presence leads to a cascade events culminating onset AD. The fibrils are formed process fibrillogenesis that, starting...

The limited solubility of natural cellulose in water and common organic solvents hinders its diverse applications, despite being one the most abundant easily accessible biopolymers on Earth. Chemical derivatization, such as carbamate (CC), offers a pathway to enhance both industrial processability. In this study, CC was synthesized by exploiting novel type IV deep eutectic solvent (DES) composed erbium trichloride urea. This DES shown be not only an environmentally friendly reaction...

Erbium(III) chloride in ethyl lactate is used as an environmentally very friendly system for the reaction of furfural and amines to yield diastereoselectively differently N,N-substituted trans-4,5-diaminocyclopent-2-enones versatile synthetic intermediates formation densely functionalized derivatives.

Oleuropein is the most important phenolic compound present in olive cultivars, but it scarcely extra virgin oil (EVOO) due to its high hydrophilicity and degradability. Thus, a set of oleuropein aglycone derivatives were synthesized by transacetylation under mild conditions with aim circumventing these drawbacks making active moiety suitable be added food fats. The (closed ring form) obtained hydrolyzing using Lewis acid catalysis. Then, permeation profiles as well antioxidant capacity...

In the present work, we proved efficacy of cellulose citrate to remove methylene blue (MB) from artificially contaminated water. MB is a widely used dye, but because its chemical aromatic structure, it significantly stable with quite slow biodegradation, causing consequent serious health problems for people and significant environmental pollution. Cellulose citrate, bio-adsorbent proposed studied by us remediate water polluted MB, produced green, cheap fast procedure that makes use two...

A new simple and effective method for the formation/cleavage of O-tert-butoxy carbonates alcohols phenols is proposed. Mesoporous silica-supported Er(III) (ErIII-MCM-41) was used as an efficient reusable solid catalyst in solvent-free ultrasound-assisted synthesis Boc-carbonate derivatives a wide range phenols. The fast, selective deprotection Boc-derivatives achieved with very low amount Er(OTf)3 ethanol under microwave irradiation. Therefore, entire protection/de-protection process...

The combination of triethylamine and [Bmim][BF₄] represents a mild method for efficient removal the Fmoc group.

The procedures for the extraction and separation of lipids nutraceutics from microalgae using classic solvents have been frequently used over years. However, these production methods usually require expensive toxic solvents. Based on our studies involving use eco-sustainable methodologies alternative solvents, we selected ethanol (EtOH) cyclopentyl methyl ether (CPME) extracting bio-oil algae. Different percentages EtOH in CPME favor an oil rich saturated fatty acids (SFA), useful to biofuel...

Similarity and competition between multicomponent reactions with similar mechanisms leading to scaffolds can be a useful tool for medicinal chemistry. In this review, we have summarized the studies disclosing mechanism of such Biginelli Hantzsch reactions. We focused our attention in particular on those exploiting similarity as an opportunity switch from one reaction another, by simply changing conditions, thus opening possibility obtain, using same experimental setup, molecular libraries...

In this paper, we evaluated the potential of two synthesized bio-based polyurethane foams, PU1 and PU2, for removal diesel gasoline from water mixtures. We started investigation with experiment in batch. The total sorption capacity S (g/g) diesel/water system was slightly higher respect to gasoline/water, a value 62 g/g 65 PU2. found that follows pseudo second-order kinetic model both materials. experimental data showed best isotherm models were obtained Langmuir Redlich–Peterson models....

The synthesis of hybrid molecules is one the current strategies drug discovery for development new lead compounds. 1,2,3-triazole moiety represents an important building block in Medicinal Chemistry, extensively present recent years. In this paper, we presented design and hybrids, containing both isatine a phenolic core. Firstly, non-commercial azide alkyne synthons were prepared by different isatines acids, respectively. Then, highly regioselective 1,4-disubstituted triazoles was obtained...

1-Indanones have been successfully prepared by means of three different non-conventional techniques, namely microwaves, high-intensity ultrasound and a Q-tube™ reactor. A library differently substituted 1-indanones has via one-pot intramolecular Friedel-Crafts acylation their efficiency “greenness” compared.