A5026086770- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Chemical Synthesis and Reactions
- Sulfur-Based Synthesis Techniques
- Psoriasis: Treatment and Pathogenesis
- Chemistry and Chemical Engineering
- Chemical Synthesis and Analysis
- Catalytic Cross-Coupling Reactions
- Therapeutic Uses of Natural Elements
- Click Chemistry and Applications
- Fungal Plant Pathogen Control
- Gastrointestinal disorders and treatments
- Microwave-Assisted Synthesis and Applications
- Pineapple and bromelain studies
- Intensive Care Unit Cognitive Disorders
- Plant-Microbe Interactions and Immunity
- Receptor Mechanisms and Signaling
- Pharmacological Receptor Mechanisms and Effects
- Autoimmune Bullous Skin Diseases
- Catalytic C–H Functionalization Methods
- Polymer-Based Agricultural Enhancements
- Monoclonal and Polyclonal Antibodies Research
- Esophageal and GI Pathology
- Biosimilars and Bioanalytical Methods
Universidad Nacional de Córdoba
2013-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2024
National University of San Juan
2017-2022
Instituto de Biotecnología de León
2019
Centro Científico Tecnológico - San Juan
2019
Hospital Universitario Infanta Leonor
2017
Hospital de León
2017
Hospital La Luz
2016
Hospital Universitario Sanitas La Zarzuela
2016
University of Calabria
2015
In search of new antifungal agrochemicals that could replace commercially available, aryl-2-mercaptobenzothiazoles were synthesized. They prepared by two methodologies, using both photostimulated reaction and microwave assisted reaction. These reactions took place without the use metallic catalyst a one-pot procedure with excellent yields (70-98%). Synthesized compounds evaluated for fungal growth inhibition against Botrytis cinerea. Most have an activity, three these showed superior...
The exploitation and use of alternative synthetic methods, in the face classical procedures that do not conform to ethics green chemistry, represent an ever-present problem pharmaceutical industry. for synthesis benzimidazoles have become a focus organic as they are building blocks strong interest development compounds with pharmacological activity. Various benzimidazole derivatives exhibit important activities such antimicrobial, antiviral, anti-inflammatory, analgesic activities, some...
In this paper a new catalyst-free and on-water method for protection of amines amino acids with di-<italic>tert</italic>-butyl dicarbonate, 9-fluorenylmethoxycarbonyl chloride, acetyl chloride tosyl is presented.
An improved and greener protocol for the synthesis of benzimidazole derivatives, starting from o -phenylenediamine, with different aldehydes is reported. Double-condensation products were selectively obtained when Er(OTf) 3 was used as catalyst in presence electron-rich aldehydes. Conversely, formation mono-condensation preferred path absence this catalyst. One major advantages these reactions a single product, avoiding extensive isolation purification products, which frequently associated...
A series of benzyl-substituted thiobenzoazoles were synthesized by an environmentally friendly approach, to search for new antifungal agrochemicals. Compounds prepared starting from 2-mercaptobenzoazoles, using KOH, benzyl halides, and water, resulting in a simple ecological method. New antifungals tested against group phytopathogenic fungi. Two compounds showed interesting activity Botrytis cinerea, Fusarium oxysporum, Aspergillus spp.: 2-((4-(trifluoromethyl)benzyl)thio)benzo[d]thiazole,...
New antifungal agrochemicals, derived from 2-(benzylsulfonyl)benzothiazole were synthesized by an environmentally friendly method, using water as reaction medium.
The exploitation and use of alternative synthetic methods, in the face classical procedures that do not conform to ethics Green Chemistry, represent an ever present problem pharmaceutical industry. for synthesis benzimidazoles have become a focus organic chemistry, as they are building blocks strong interest development compounds with pharmacological activity. Various benzimidazole derivatives exhibit important activities such antimicrobial, antiviral, anti-inflammatory analgesic some...
Annona emarginata (Schltdl.) H. Rainer, commonly known as "arachichú", "araticú", "aratigú", and "yerba mora", is a plant that grows in Argentina. Infusions decoctions are used folk medicine gargle against throat pain for calming toothache; another way to use the these purposes chewing its leaves. Extracts from bark, flowers, leaves, fruits A. were subjected antibacterial assays panel of Gram (+) (-) pathogenic bacteria according Clinical Laboratory Standards Institute protocols. stem bark...
The benzimidazole ring of the heterocyclic pharmacophores is one most widespread and studied systems in nature. derivative synthesis study a crucial point for development clinically available benzimidazole-based drug. Here, we report simple microwave assisted method 1,2-disubstituted benzimidazoles. combination molar ratio N-phenyl-o-phenylenediamine:benzaldehyde (1:1) using irradiation only 1% mol Er(OTf)3 provides an efficient environmental mild access to diversity benzimidazoles under...
<b><i>Background:</i></b> Acute guttate psoriasis (AGP) is a distinctive clinical entity with good response to treatment narrow-band ultraviolet B (NB-UVB). <b><i>Objective:</i></b> To investigate the results of NB-UVB phototherapy in adult patients psoriasis. <b><i>Material and Methods:</i></b> We carried out prospective, open, observational study. Patients over 18 years more than 5% body surface area affected were...
Background: Neurodegenerative, neurological and mental disorders, as well substance abuse have a worldwide high incidence rate, becoming relevant factors that contribute to premature morbidity mortality. Dopamine is known be involved in these pathologies. The key focus the search for new drugs, alleviate or cure diseases, pursuing design of compounds with both efficacy fewer adverse effects order obtain novel agents capable restoring homeostasis CNS dopaminergic neurotransmission...
Abstract BACKGROUND Growing concerns about sustainability have driven the search for eco‐friendly pest management solutions. Combining natural and synthetic compounds within controlled release systems is a promising strategy. This study investigated co‐encapsulation of compound citral (Cit) antifungal cyproconazole (CPZ) using two water‐based nanocarriers: solid lipid nanoparticles (SLNs) chitosan (CSNPs). RESULTS Both CSNPs SLNs loaded with Cit + CPZ displayed superior activity against...
Abstract Triadimefon (TDM) and cyproconazole (CPZ) are two triazoles widely used as fungicides. Several azoles were synthesised starting from commercial TDM CPZ. The compounds evaluated against phytopathogenic filamentous fungi, including Aspergillus fumigatus (AF), A. niger (AN), ustus (AU), japonicus (AJ), terreus (AT), Fusarium oxysporum Botrytis cinerea isolated grapevine in the province of San Juan, Argentina. Three...
Abstract The Stille cross‐coupling reaction and the Suzuki are used to synthesize aryl derivatives of triadimefon (I) cyproconazole (VI).
Abstract with Boc 2 O, Fmoc‐Cl, Ac‐Cl and Tos‐Cl