A5040369152- Synthesis and biological activity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer therapeutics and mechanisms
- Metal complexes synthesis and properties
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Fullerene Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Graphene and Nanomaterials Applications
- Computational Drug Discovery Methods
- Free Radicals and Antioxidants
- Quinazolinone synthesis and applications
- Analytical Chemistry and Chromatography
- Microwave-Assisted Synthesis and Applications
- HIV/AIDS drug development and treatment
- Fungal Plant Pathogen Control
- Nonlinear Optical Materials Research
- Chemical Synthesis and Analysis
- Multicomponent Synthesis of Heterocycles
- Microbial Natural Products and Biosynthesis
- Nanoplatforms for cancer theranostics
- Carbohydrate Chemistry and Synthesis
- Luminescence and Fluorescent Materials
University of Silesia in Katowice
2016-2025
Silesian University of Technology
2024
Holy Cross Hospital
2005
Abstract Background Falls in older people have been characterized extensively the literature, however little has reported regarding falls middle-aged and younger adults. The objective of this paper is to describe perceived cause, environmental influences resultant injuries 1497 young (20–45 years), (46–65 years) (> 65 men women from Baltimore Longitudinal Study on Aging. Methods A descriptive study where participants completed a fall history questionnaire describing circumstances...
In this study, series of ring-substituted 2-styrylquinazolin-4(3H)-one and 4-chloro-2-styrylquinazoline derivatives were prepared. The syntheses the discussed compounds are presented. analyzed by RP-HPLC to determine lipophilicity. They tested for their inhibitory activity on photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary vitro screening synthesized was also performed against four mycobacterial strains eight fungal strains. Several showed...
Thiosemicarbazones (TSCs) are an interesting class of ligands that show a diverse range biological activity, including anti-fungal, anti-viral and anti-cancer effects. Our previous studies have demonstrated the potent in vivo anti-tumor activity novel TSCs their ability to overcome resistance clinically used chemotherapeutics. In current study, 35 6 different classes were designed using combination retro-fragments appear other TSCs. Additionally, di-substitution at terminal N4 atom, which...
// Katarzyna Malarz 1, 2 , Anna Mrozek-Wilczkiewicz 2, 3 Maciej Serda 1 Marta Rejmund Jaroslaw Polanski and Robert Musiol Institute of Chemistry, University Silesia in Katowice, Poland Silesian Center for Education Interdisciplinary Research, Chorzów, A. Chełkowski Physics, Correspondence to: Musiol, email: robert.musiol@us.edu.pl Keywords: thiosemicarbazones; anticancer; iron chelators; reactive oxygen species; oxidative stress Received: July 06, 2017 ...
Ionic liquids are viewed as green media for many engineering applications and exhibit exceptional properties, including negligible vapor pressure, null flammability, wide liquid range, high thermal chemical stabilities. We present new thermophysical properties of 1-alkyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imides ([CnC1pyr][NTf2] with n = 3, 4) future application them heat-transfer media. The speed sound was measured at pressures up to 100 MPa temperatures from 293 K 318 K....
A group of styrylquinolines were synthesized and tested for their anti-proliferative activity. Anti-proliferative activity was evaluated against the human colon carcinoma cell lines that had a normal expression p53 protein (HCT116 p53+/+) mutants with disabled TP53 gene p53-/-) GM 07492 fibroblast line. SAR study revealed importance Cl OH as substituents in styryl moiety. Several compounds found to have marked similar or better than doxorubicin more active null wild type cells. The cellular...
A series of novel styrylquinolines with the benzylidene imine moiety were synthesized and spectroscopically characterized for their applicability in cellular staining. The spectroscopic study revealed absorption ultraviolet–visible region (360–380 nm) emission that covered blue-green range light (above 500 nm). fluorescence quantum yields also determined, which amounted to 0.079 best-case scenario. structural features are behind these values discussed. An analysis properties theoretical...
Pancreatic ductal adenocarcinoma (PDAC) is recognized as one of the most formidable cancers, largely due to its distinct microenvironment characterized predominantly by extensive desmoplastic stroma. In this study, we synthesized three novel water-soluble fullerene-based nanomaterials targeting EGFR protein. The direct amination fullerene carbon atoms, was followed conjugation with a modified derivative inhibitor-erlotinib, resulting in formation derivatives. Further investigation into PAN02...
In the study, a series of twelve ring-substituted 4-hydroxy-1H-quinolin-2-one derivatives were prepared. The procedures for synthesis compounds are presented. analyzed using RP-HPLC to determine lipophilicity and tested their photosynthesis-inhibiting activity spinach (Spinacia oleracea L.) chloroplasts. All synthesized also evaluated antifungal in vitro screening with eight fungal strains. For all compounds, relationships between chemical structure studied discussed, as well...