A5075902170- Computational Drug Discovery Methods
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic Processes in Materials Science
- Machine Learning in Materials Science
- Synthesis and biological activity
- Metal complexes synthesis and properties
- Free Radicals and Antioxidants
- Click Chemistry and Applications
- Bioactive Compounds and Antitumor Agents
- HIV/AIDS drug development and treatment
- Spectroscopy and Chemometric Analyses
- Catalysts for Methane Reforming
- Biochemical Analysis and Sensing Techniques
- Cancer therapeutics and mechanisms
- Chemistry and Chemical Engineering
- Nanomaterials for catalytic reactions
- Microbial Natural Products and Biosynthesis
- Fungal Plant Pathogen Control
- Catalysis for Biomass Conversion
- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- Molecular spectroscopy and chirality
- Photodynamic Therapy Research Studies
University of Silesia in Katowice
2015-2024
University of Wrocław
1973-2014
Silesian University in Opava
1991-2007
University of Bielsko-Biała
2003
Medical University of Warsaw
1997-2003
Université Paris Cité
2002
Institut Gustave Roussy
2002
Centre National de la Recherche Scientifique
2002
In this study, series of ring-substituted 2-styrylquinazolin-4(3H)-one and 4-chloro-2-styrylquinazoline derivatives were prepared. The syntheses the discussed compounds are presented. analyzed by RP-HPLC to determine lipophilicity. They tested for their inhibitory activity on photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary vitro screening synthesized was also performed against four mycobacterial strains eight fungal strains. Several showed...
Thiosemicarbazones (TSCs) are an interesting class of ligands that show a diverse range biological activity, including anti-fungal, anti-viral and anti-cancer effects. Our previous studies have demonstrated the potent in vivo anti-tumor activity novel TSCs their ability to overcome resistance clinically used chemotherapeutics. In current study, 35 6 different classes were designed using combination retro-fragments appear other TSCs. Additionally, di-substitution at terminal N4 atom, which...
// Katarzyna Malarz 1, 2 , Anna Mrozek-Wilczkiewicz 2, 3 Maciej Serda 1 Marta Rejmund Jaroslaw Polanski and Robert Musiol Institute of Chemistry, University Silesia in Katowice, Poland Silesian Center for Education Interdisciplinary Research, Chorzów, A. Chełkowski Physics, Correspondence to: Musiol, email: robert.musiol@us.edu.pl Keywords: thiosemicarbazones; anticancer; iron chelators; reactive oxygen species; oxidative stress Received: July 06, 2017 ...
Quantitative Structure Activity Relationship (QSAR) is a term describing variety of approaches that are substantial interest for chemistry. This method can be defined as indirect molecular design by the iterative sampling chemical compounds space to optimize certain property and thus indirectly structure having this property. However, modeling interactions molecules in biological systems provides highly noisy data, which make predictions roulette risk. In paper we briefly review origins...
Using the Kohonen neural network, electrostatic potentials on molecular surfaces of 14 styrylquinoline derivatives were drawn as comparative two-dimensional maps and compared with their known human immunodeficiency virus (HIV)-1 replication blocking potency in cells. A feature potential map was discovered to be related HIV-1 activity used unmask further five analogues, previously described but whose cytotoxicity precluded an estimation activity, predict 10 new compounds while experimental...
In the study, a series of twelve ring-substituted 4-hydroxy-1H-quinolin-2-one derivatives were prepared. The procedures for synthesis compounds are presented. analyzed using RP-HPLC to determine lipophilicity and tested their photosynthesis-inhibiting activity spinach (Spinacia oleracea L.) chloroplasts. All synthesized also evaluated antifungal in vitro screening with eight fungal strains. For all compounds, relationships between chemical structure studied discussed, as well...
In the paper a novel approach to thermochemical utilization of low rank coal, flotation concentrates and municipal refuse derived fuels was presented. The economic attractiveness coals is limited that why they are commonly stored at excavation heaps causing additional costs risk endogenous fires occurrence. One crucial parameters determining usability fuel in gasification process its reactivity. study several coals, were tested terms their reactivity steam gasification. coal 50% carbon...
The gasification technology of refuse-derived fuels (RDF) can represent a future alternative to the global hydrogen production and pathway for development circular economy. paper presents an innovative way utilizing RDF through their oxygen/steam co-gasification with bituminous coal rich gas. Five different samples (RDF1÷RDF5) were investigated. in-depth analyses blends amounts (10, 15 20%w/w) under various temperature conditions conducted application Hierarchical Clustering Analysis (HCA)....
In this study, a series of fourteen ring-substituted 8-hydroxyquinoline derivatives were prepared. The synthesis procedures are presented. compounds analyzed using RP-HPLC to determine lipophilicity. They tested for their activity related inhibition photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary vitro screening the synthesized was also performed against four mycobacterial strains and eight fungal strains. Several showed biological comparable...