A5019200770- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Pancreatic function and diabetes
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Fatty Acid Research and Health
- Growth Hormone and Insulin-like Growth Factors
- GABA and Rice Research
- Food composition and properties
- Protein Hydrolysis and Bioactive Peptides
- Pharmacological Effects and Assays
- Regulation of Appetite and Obesity
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Blood Pressure and Hypertension Studies
- Hormonal and reproductive studies
- Nutrition, Genetics, and Disease
- Nanoparticle-Based Drug Delivery
- Hormonal Regulation and Hypertension
- Chronic Kidney Disease and Diabetes
- Glycosylation and Glycoproteins Research
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2025
Chongqing Medical University
2016-2025
Huazhong Agricultural University
2023-2024
Henan Institute of Science and Technology
2022
Boehringer Ingelheim (United States)
2021
Purdue University West Lafayette
1959-2017
University of Gothenburg
1993-2004
Lund University
2004
Sahlgrenska University Hospital
1990-1996
Wallenberg Wood Science Center
1993
Ghrelin is produced mainly by endocrine cells in the stomach and an endogenous ligand for growth hormone secretagogue receptor (GHS-R). It also influences feeding behavior, metabolic regulation, energy balance. affects islet secretion, expression of ghrelin GHS-R pancreas has been reported. In human islets, highest pre- neonatally. We examined rat islets during development with immunocytochemistry situ hybridization. studied effect on insulin secretion from INS-1 (832/13) these cells. found...
Angiotensin receptor blockers (ARBs) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been used as the standard therapy for patients with diabetic kidney disease (DKD). However, how these two drugs possess additive renoprotective effects remains unclear. Here, we conducted single-cell RNA sequencing to profile cell transcriptome of db/db mice treated vehicle, ARBs, SGLT2i, or ARBs plus using db/m control. We identified 10 distinct clusters cells predominant proximal tubular (PT)...
High-fat diet (HFD) during lactation alters milk composition and is associated with development of metabolic diseases in the offspring. We hypothesized that HFD affects microRNA (miRNA) mRNA content, which potentially impact offspring development. Our objective was to determine effect maternal on secreted transcriptome. To meet this objective, 4 wk old female ICR mice were divided into two treatments: control containing 10% kcal fat 60% fat. After CD or HFD, bred while continuously fed same...
Lipids may serve as coupling factors in KATP-independent glucose sensing β-cells. We have previously demonstrated that β-cells harbor lipase activities, one of which is the hormone-sensitive lipase. Whether β-cell lipases are critical for glucose-stimulated insulin secretion (GSIS) by providing lipid-derived signals from endogenous lipids unknown. Therefore, using a inhibitor (orlistat), we examined whether inhibition reduces secretion. Islet lipolysis stimulated and diglyceride activity was...
SUMMARY— Boneless, trimmed steaks (U. S. Good) from the longissimns dorsi muscle (loin) and semimembranosus (top‐round) conventionally cut loin were removed 8 days post‐mortem, quick‐frozen stored at −18°C to −23°C for three storage periods, 0, 6, 9 months. Steaks sampled each period cooked an internal temperature of 70°C in a microwave oven electric range. Quality was evaluated by chemical tests, sensory evaluations cooking loss data. Storage up 6 months had little effect on with exception...
In the previous studies we have shown that testosterone increases lipolytic responsiveness to catecholamines in rat white adipocytes, and is associated with an up-regulation of beta-adrenergic receptor density. However, postreceptor events involved induced enhancement activated lipolysis these cells not been adequately studied, were therefore investigated present study. Male Sprague Dawley rats divided into three groups: control, castrated, castrated treated testosterone. The...
Abstract The effects of growth hormone (GH) and testosterone, alone or in combination, on the regulation lipolysis isolated adipocytes from hypophysectomized rats were investigated. Male Sprague-Dawley at 50 days age. One week after operation, hormonal replacement therapy with l -thyroxine hydrocortisone acetate was given to rats. Groups treated GH (1·33 mg/kg, daily), testosterone (10 once) combination. After one treatment, pooled epididymal perirenal fat pads glycerol release isoproterenol...
Abstract Objective : The influence of growth hormone (GH) on the regulation lipolytic response to specific agonists β‐adrenoceptors and several post‐receptor steps in cascade were investigated. Research Methods Procedures Adipose tissues from rats incubated with or without GH (1.38 nM). After a 24‐hour incubation, isolated adipocytes prepared for different assays. Rats hypophysectomized. One week after operation, l‐thyroxine hydrocortisone acetate was given hypophysectomized rats. group...
Growth hormone (GH) has a lipolytic effect in adipose tissue but this may differ from various fat depots. This latter possibility was investigated the present study, which effects of GH vivo on catecholamine‐induced lipolysis and number β‐adrenergic receptors isolated adipocytes different depots hypophysectomized rats were investigated. Female male Sprague‐Dawley or sham‐operated at 45 days age. One week after operation, hormonal replacement therapy with L‐thyroxine hydrocortisone acetate...
Cerebral vasodilation in hypoxia may involve endothelium-derived relaxing factor-nitric oxide (NO). An inhibitor of NO formation, N omega-nitro-L-arginine (LNA, 100 micrograms/kg i.v.), was given to conscious sheep (n = 6) during normoxia and again hypocapnic (arterial PO2 approximately 38 Torr). Blood samples were obtained from the aorta sagittal sinus, cerebral blood flow (CBF) measured with 15-microns radiolabeled microspheres. During normoxia, LNA elevated (P < 0.05) mean arterial...
In type 2 diabetes, beta-cells become glucose unresponsive, contributing to hyperglycemia. To address this problem, we recently created clonal insulin-producing cell lines from the INS-1 insulinoma line, which exhibit responsiveness ranging poor robust. Here, mechanisms that determine secretory performance were identified by functionally comparing glucose-responsive 832/13 with glucose-unresponsive 832/2 beta-cells. Thus, insulin secretion cells maximally rose 8-fold in response glucose,...
Journal Article Biological Value of Rangeland Grasshoppers as a Protein Concentrate Get access D. N. Ueckert, Ueckert Texas Tech University, Lubbock, 79409 Search for other works by this author on: Oxford Academic PubMed Google Scholar S. P. Yang, Yang R. C. Albin Economic Entomology, Volume 65, Issue 5, 1 October 1972, Pages 1286–1288, https://doi.org/10.1093/jee/65.5.1286 Published: 01 1972 history Received: 16 January